Novel Insights into the Mechanisms Leading to β-Cell Dysfunction and Demise in Type 1 Diabetes
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".
Deadline for manuscript submissions: 30 November 2024 | Viewed by 5307
Special Issue Editors
Interests: type 1 diabetes; interferon pathway; pancreatic islets
Special Issue Information
Dear Colleagues,
Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by pancreatic islet inflammation (insulitis) and specific pancreatic β-cell destruction by the immune system. Although the precise etiology and pathological mechanisms leading to the autoimmune attack are mostly unclear, it is well accepted that insulitis takes place in the context of a conflicting dialogue between the immune cells, which release cytokines and chemokines into the islet microenvironment and deliver pro-apoptotic signals, and pancreatic β-cells, which generates signals that will attract and activate immune cells to the islets. This dialogue is determined by multiple combinations of the host genetic susceptibility (i.e., candidate genes) and environmental factors (e.g., viral infections and diet).
In this Special Issue, we are interested in studies that further contribute to the mechanisms and signaling pathways underlying β-cell dysfunction and death in the context of type 1 diabetes. Additionally, we welcome manuscripts that provide insights into mechanisms of β-cell protection against inflammation and immune attack.
We accept contributions to, but not limited to, the following themes:
- Genetic and environmental factors leading to β-cell dysfunction and apoptosis;
- Signaling pathways altered in β-cells under a proinflammatory context;
- Metabolic and functional changes in β-cells under a proinflammatory context;
- Mechanisms of β-cell survival against proinflammatory cytokines;
- Possible targets for β-cell protection that could lead to the prevention and treatment of type 1 diabetes.
Dr. Laura Marroqui
Dr. Reinaldo Sousa Dos Santos
Guest Editors
Keywords
- type 1 diabetes
- pancreatic beta cells
- insulitis
- cytokines
- T1D prevention and treatment
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