Protein Misfolded Oligomers and Neurodegenerative Diseases
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".
Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 484
Special Issue Editors
Interests: neurodegeneration; drug investigation; protein aggregation; translational research
Special Issues, Collections and Topics in MDPI journals
Interests: amyloid aggregation; autophagy; natural polyphenols; neurodegenerative diseases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear colleagues,
The conversion of peptides and proteins into highly structured fibrillar aggregates is associated with a number of neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and many others. In such pathological conditions, an important cytotoxic role is thought to be played by small soluble oligomers that accumulate during the aggregation process or released by mature fibrils.
Over the years, the structural features of toxic protein oligomers, including small-size and high solvent-exposed hydrophobicity, which are responsible for aberrant interactions with cellular components, have been investigated, as well as various events that lead to neuronal dysfunction. Moreover, several potential therapeutic strategies have been explored, including small molecules, antibodies, and natural compounds, some of which exhibit promising outcomes.
This Special Issue welcomes the submission of original research papers and reviews on the most advanced developments in the above-mentioned topics, with special attention to possible therapeutic approaches targeting protein misfolded oligomers.
Dr. Claudia Capitini
Dr. Manuela Leri
Guest Editors
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Keywords
- protein misfolded oligomers
- oligomer structure
- neurodegeneration
- aggregation kinetics
- neurotoxicity
- drug discovery
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