Advanced Research in Proteinopathies
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".
Deadline for manuscript submissions: 31 January 2025 | Viewed by 2044
Special Issue Editors
Interests: neurodegeneration; drug investigation; protein aggregation; translational research
Special Issues, Collections and Topics in MDPI journals
Interests: amyloid aggregation; autophagy; natural polyphenols; neurodegenerative diseases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Proteinopathies are a family of diseases characterized by the accumulation of specific proteins within neurons or in the brain parenchyma that lead to synaptic dysfunction and neuronal loss. Examples for proteinopathies are Alzheimer’s disease, Parkinson’s disease, Lewy body disease, amyotrophic lateral sclerosis and fronto-temporal lobar degeneration. Typically, in a disease condition, the unstructured proteins change their conformation leading to small oligomers that eventually aggregate into higher-order structures. Prion disease is an exception within the family of proteinopathies, as the aggregated prion protein is highly infectious and can self-aggregate and propagate.
Over the years, the structural and morphological features of several protein aggregate species have been investigated, as well as the cellular events that lead to neuronal dysfunction. Moreover, a number of potential therapeutic strategies have been explored, including small molecules, antibodies and natural compounds, some of them showing promising outcomes.
This Special Issue welcomes the submission of original research papers and reviews on the most advanced developments in the above-mentioned topics, with special attention on possible therapeutic approaches targeting misfolded proteins.
Dr. Claudia Capitini
Dr. Manuela Leri
Guest Editors
Manuscript Submission Information
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Keywords
- protein misfolding
- oligomers
- amyloid fibrils
- amorphous aggregates
- prion
- neurodegeneration
- aggregation kinetics
- neurotoxicity
- drug discovery
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