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Biomedicines
Special Issues
Gastric Cancer: From Pathophysiologic Mechanisms to Therapeutic Strategies
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Gastric Cancer: From Pathophysiologic Mechanisms to Therapeutic Strategies

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cancer Biology and Oncology".

Deadline for manuscript submissions: closed (30 June 2024) | Viewed by 3705

Special Issue Editors

Dr. Jiang-Jiang Qin

E-Mail Website
Guest Editor
Institute of Basic Medicine and Cancer, Chinese Academy of Sciences (CAS), Hangzhou, China
Interests: gastric cancer; UPS; small molecule inhibitors; targeted protein degradation; traditional Chinese medicine
Dr. Xiaoqing Guan

E-Mail Website
Guest Editor
Zhejiang Cancer Hospital, Hangzhou, China
Interests: gastric cancer; bioinformatics; targeted therapy; molecular mechanisms of drug resistance

Special Issue Information

Dear Colleagues,

Despite the substantial progress made in our understanding of the causes, pathogenesis, diagnosis, and treatment of gastric cancer in the past few decades, this disease remains one of the leading causes of cancer death, especially in China.  The identification and validation of new and effective biomarkers and drug targets are critically needed for patients with gastric cancer. Recently, cutting-edge omics technologies, such as spatiotemporal omics and single-cell omics, have emerged, changing cancer research and treatment. These powerful tools could help make significant progress in exploring the tumor microenvironment, cancer cell evolution and interaction with immune and stromal cells, etc., and identifying more specific and promising biomarkers and targets for human cancer, including gastric cancer. 

We invite authors to submit original research and review articles that focus on basic and translational research on gastric cancer with various new and powerful technologies. The goal is to stimulate research and clinical interest in developing strategies for the prediction, prevention, diagnosis, and treatment of gastric cancer to finally improve the treatment outcomes in patients with this malignant disease.

Dr. Jiang-Jiang Qin
Dr. Xiaoqing Guan
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gastric cancer
  • biomarkers
  • targets
  • diagnosis
  • treatment
  • single-cell omics
  • spatiotemporal omics

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Published Papers (3 papers)

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Research

18 pages, 1647 KiB  
Article
High Expression of AhR and Environmental Pollution as AhR-Linked Ligands Impact on Oncogenic Signaling Pathways in Western Patients with Gastric Cancer—A Pilot Study
by Martine Perrot-Applanat, Cynthia Pimpie, Sophie Vacher, Marc Pocard and Véronique Baud
Biomedicines 2024, 12(8), 1905; https://doi.org/10.3390/biomedicines12081905 - 20 Aug 2024
Viewed by 913
Abstract
The vast majority of gastric cancer (GC) cases are adenocarcinomas including intestinal and diffuse GC. The incidence of diffuse GC, often associated with poor overall survival, has constantly increased in Western countries. Epidemiological studies have reported increased mortality from GC after occupational exposure [...] Read more.
The vast majority of gastric cancer (GC) cases are adenocarcinomas including intestinal and diffuse GC. The incidence of diffuse GC, often associated with poor overall survival, has constantly increased in Western countries. Epidemiological studies have reported increased mortality from GC after occupational exposure to pro-carcinogens that are metabolically activated by cytochrome P450 enzymes through aryl hydrocarbon receptor (AhR). However, little is known about the role of AhR and environmental AhR ligands in diffuse GC as compared to intestinal GC in Western patients. In a cohort of 29, we demonstrated a significant increase in AhR protein and mRNA expression levels in GCs independently of their subtypes and clinical parameters. AhR and RHOA mRNA expression were correlated in diffuse GC. Further, our study aimed to characterize in GC how AhR and the AhR-related genes cytochrome P450 1A1 (CYP1A1) and P450 1B1 (CYP1B1) affect the mRNA expression of a panel of genes involved in cancer development and progression. In diffuse GC, CYP1A1 expression correlated with genes involved in IGF signaling, epithelial–mesenchymal transition (Vimentin), and migration (MMP2). Using the poorly differentiated KATO III epithelial cell line, two well-known AhR pollutant ligands, namely 2-3-7-8 tetrachlorodibenzo-p-dioxin (TCDD) and benzo[a]pyrene (BaP), strongly increased the expression of CYP1A1 and Interleukin1β (IL1B), and to a lesser extend UGT1, NQO1, and AhR Repressor (AhRR). Moreover, the increased expression of CYP1B1 was seen in diffuse GC, and IHC staining indicated that CYP1B1 is mainly expressed in stromal cells. TCDD treatment increased CYP1B1 expression in KATO III cells, although at lower levels as compared to CYP1A1. In intestinal GC, CYP1B1 expression is inversely correlated with several cancer-related genes such as IDO1, a gene involved in the early steps of tryptophan metabolism that contributes to the endogenous AhR ligand kynurenine expression. Altogether, our data provide evidence for a major role of AhR in GC, as an environmental xenobiotic receptor, through different mechanisms and pathways in diffuse and intestinal GC. Our results support the continued efforts to clarify the identity of exogenous AhR ligands in diffuse GC in order to define new therapeutic strategies. Full article
(This article belongs to the Special Issue Gastric Cancer: From Pathophysiologic Mechanisms to Therapeutic Strategies)
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18 pages, 1696 KiB  
Article
Prognostic Influence of Galectin-1 in Gastric Adenocarcinoma
by Cristina Díaz del Arco, Lourdes Estrada Muñoz, María de los Ángeles Cerón Nieto, Elena Molina Roldán, María Jesús Fernández Aceñero and Soledad García Gómez de las Heras
Biomedicines 2024, 12(7), 1508; https://doi.org/10.3390/biomedicines12071508 - 7 Jul 2024
Viewed by 915
Abstract
Galectin-1 (Gal-1), a member of the human lectin family, has garnered attention for its association with aggressive behavior in human tumors, prompting research into the development of targeted drugs. This study aims to assess the staining pattern and prognostic significance of Gal-1 immunohistochemical [...] Read more.
Galectin-1 (Gal-1), a member of the human lectin family, has garnered attention for its association with aggressive behavior in human tumors, prompting research into the development of targeted drugs. This study aims to assess the staining pattern and prognostic significance of Gal-1 immunohistochemical expression in a homogeneous cohort of Western patients with gastric cancer (GC). A total of 149 cases were included and tissue microarrays were constructed. Stromal Gal-1 expression was observed to some extent in most tumors, displaying a cytoplasmic pattern. Cases with stromal Gal-1 overexpression showed significantly more necrosis, lymphovascular invasion, advanced pTNM stages, recurrences, and cancer-related deaths. Epithelial Gal-1 expression was present in 63.8% of the cases, primarily exhibiting a cytoplasmic pattern, and its overexpression was significantly associated with lymphovascular invasion, peritumoral lymphocytic infiltration, and tumor-related death. Kaplan/Meier curves for cancer-specific survival (CSS) revealed a significantly worse prognosis for patients with tumors exhibiting stromal or epithelial Gal-1 overexpression. Furthermore, stromal Gal-1 expression stratified stage III patients into distinct prognostic subgroups. In a multivariable analysis, increased stromal Gal-1 expression emerged as an independent prognostic factor for CSS. These findings underscore the prognostic relevance of Gal-1 and suggest its potential as a target for drug development in Western patients with GC. Full article
(This article belongs to the Special Issue Gastric Cancer: From Pathophysiologic Mechanisms to Therapeutic Strategies)
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15 pages, 4790 KiB  
Article
Expression of Serpin Family E Member 1 (SERPINE1) Is Associated with Poor Prognosis of Gastric Adenocarcinoma
by Jie Lv, Chunyang Yu, Hanhan Tian, Tao Li and Changhua Yu
Biomedicines 2023, 11(12), 3346; https://doi.org/10.3390/biomedicines11123346 - 18 Dec 2023
Viewed by 1467
Abstract
Background: The aberrant expression of serpin family E member 1 (SERPINE1) is associated with carcinogenesis. This study assessed the alteration of SERPINE1 expression for an association with gastric adenocarcinoma prognosis. Methods: The Cancer Genome Atlas (TCGA) dataset was applied to investigate the impact [...] Read more.
Background: The aberrant expression of serpin family E member 1 (SERPINE1) is associated with carcinogenesis. This study assessed the alteration of SERPINE1 expression for an association with gastric adenocarcinoma prognosis. Methods: The Cancer Genome Atlas (TCGA) dataset was applied to investigate the impact of SERPINE1 expression on the survival of patients afflicted with gastric cancer. Subsequently, 136 samples from the Affiliated Huaian No. 1 People’s Hospital of Nanjing Medical University were subjected to qRT-PCR and Western blot to validate the expression level of SERPINE1 between tumor and adjacent normal tissues. The correlation between the expression of SERPINE1 with the clinicopathological features in TCGA patients was analyzed using Wilcoxon signed-rank and logistic regression tests. The potential molecular mechanism associated with SERPINE1 expression in gastric cancer were confirmed using gene set enrichment analysis (GSEA). Results: The TCGA data showed that SERPINE1 was overexpressed in tumor tissues compared to normal mucosae and associated with the tumor T stage and pathological grade. SERPINE1 overexpression was associated with the poor overall survival (OS) of patients. The findings were confirmed with 136 patients, that is, SERPINE1 expression was associated with poor OS (hazard ratio (HR): 1.82; 95% confidence interval (CI): 0.84–1.83; p = 0.012)) as an independent predictor (HR: 2.11, 95% CI: 0.81–2.34; p = 0.009). The resulting data were further processed by GSEA showed that SERPINE1 overexpression was associated with the activation of EPITHELIAL_MESENCHYMAL_TRANSITION, TNFA_SIGNALING_VIA_NFKB, INFLAMMATORY_RESPONSE, ANGIOGENESIS, and HYPOXIA. Conclusions: SERPINE1 overexpression is associated with a poor gastric cancer prognosis. Full article
(This article belongs to the Special Issue Gastric Cancer: From Pathophysiologic Mechanisms to Therapeutic Strategies)
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