Novel Approaches to the Regeneration and Repair of the Nervous System: Neuronal Reprogramming
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Neurobiology and Clinical Neuroscience".
Deadline for manuscript submissions: closed (31 May 2024) | Viewed by 1620
Special Issue Editor
Special Issue Information
Dear Colleagues,
While adult neurogenesis has been observed in specific brain regions, the potential for generating new neurons in the adult human central nervous system is severely constrained. Despite significant advances in medicine, the task of replenishing lost neurons following central nervous system injuries and neurodegenerative diseases remains highly challenging. A promising avenue to address this challenge is in situ neuronal reprogramming, an emerging approach that involves converting somatic cells into induced neurons capable of functioning like existing neurons. However, bridging the gap between fundamental scientific research and clinical applications in this field poses a substantial challenge. Neuronal reprogramming involves various obstacles, including cell death, low reprogramming efficiency, difficulties with off-target gene delivery, incomplete reprogramming, and the unintended generation of undesirable cell types. Effectively overcoming these critical hurdles is essential to pave the way for a future where neuronal reprogramming has transformed the landscape of medicine and human health. This Special Issue aims to gather original research articles and review papers specifically focused on neuronal reprogramming, both in vivo and in vitro, with a particular emphasis on addressing the aforementioned obstacles. By exploring innovative solutions to these challenges, we can envision a future where the potential of neuronal reprogramming is fully harnessed to revolutionize medical interventions and enhance overall human health.
Dr. Xuanyu Chen
Guest Editor
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Keywords
- neuronal reprogramming
- astrocyte
- NG2 cells
- brain injury
- spinal cord injury
- AAV
- gene delivery
- neurodegenerative diseases
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