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Biomedicines
Special Issues
Crohn’s Disease and Ulcerative Colitis: Pathophysiology and New Therapeutic Strategies
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Crohn’s Disease and Ulcerative Colitis: Pathophysiology and New Therapeutic Strategies

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Endocrinology and Metabolism Research".

Deadline for manuscript submissions: closed (31 August 2024) | Viewed by 1182

Special Issue Editors

Dr. Affifa Farrukh

E-Mail Website
Guest Editor
Department of Gastroenterology, Nuffield Hospital, Scraptoft Lane, Leicester LE5 5HY, UK
Interests: irritable bowel syndrome；microscopic colitis; Crohn’s disease and ulcerative colitis
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. John Mayberry

E-Mail Website
Guest Editor
Department of Gastroenterology, Nuffield Hospital, Scraptoft Lane, Leicester LE5 5HY, UK
Interests: inflammatory bowel disease; coeliac disease; achalasia; screening; epidemiology; public health
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue concerns the recent therapeutic developments in the management of Crohn's Disease and Ulcerative Colitis. There will be a focus on the role of the intestinal microbiome in the development of Crohn's Disease and Ulcerative Colitis, and the therapeutic place of new probiotics in the management of these conditions. The Special Issue also reflects on the place of newer biologic therapies and JAK inhibitors in the control of inflammatory process. Stem cell therapy and other new drugs targeting the inflammatory process will also be reviewed. All studies and reviews relating to the mechanisms and therapeutic strategies of Crohn's Disease are welcome.

You may choose our Joint Special Issue in JCM.

Dr. Affifa Farrukh
Prof. Dr. John Mayberry
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microbiome
  • probiotics
  • biologics
  • JAK inhibitors
  • stem cell therapy
  • new molecules

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Published Papers (1 paper)

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18 pages, 5018 KiB  
Case Report
Intestinal and Extraintestinal Findings of Graft-versus-Host Disease on CT: A Case Series with Radiological and Histopathological Correlations
by Barbara Brogna, Camilla Frieri, Antonio Maria Risitiano, Luigi Urciuoli, Gabriella Storti, Lidia Santoro, Eleonora Urciuoli, Giovanni De Chiara, Pasquale Cretella, Carmen Sementa, Lanfranco Aquilino Musto and Francesca Maccioni
Biomedicines 2024, 12(7), 1516; https://doi.org/10.3390/biomedicines12071516 - 8 Jul 2024
Cited by 1 | Viewed by 952
Abstract
Graft-versus-host disease (GVHD) is an expected and relatively common complication after allogeneic hematopoietic stem cell transplantation. It may affect different organs and typically involves the skin, liver, and gastrointestinal tract (GI-GVHD). GI-GVHD may show heterogeneous presentations with peculiar diagnostic implications. Although an endoscopic [...] Read more.
Graft-versus-host disease (GVHD) is an expected and relatively common complication after allogeneic hematopoietic stem cell transplantation. It may affect different organs and typically involves the skin, liver, and gastrointestinal tract (GI-GVHD). GI-GVHD may show heterogeneous presentations with peculiar diagnostic implications. Although an endoscopic biopsy is considered the “gold standard” for the diagnosis of GI-GVHD, its broad application is limited due to the poor clinical conditions usually present in these patients, including thrombocytopenia. In the emergency department, enhanced computed tomography (CECT) has emerged as the best imaging modality for the evaluation of GI damage in frail patients. However, the role of CT in the context of either acute or chronic GI-GVHD has not been systematically investigated. Herein, we focus on the radiological features found on CECT in five patients with GI-GVHD confirmed on histology. CECT was performed for the persistence of GI symptoms in three cases (case 1, case 3, and case 4), for small bowel occlusion in one case (case 5), and for acute GI symptoms in one case (case 2). Serpiginous intestinal wall appearance with multisegmental parietal thickness and homogeneous, mucosal, or stratified small bowel enhancement were common features. Colic involvement with segmental or diffuse parietal thickness was also present. One patient (case 5) presented with inflammatory jejunal multisegmental stenosis with sub-occlusion as a chronic presentation of GI-GVHD. Regarding mesenterial findings, all five patients presented comb signs in the absence of lymphadenopathy. Extraintestinal findings included biliary tract dilatation in two cases (case 2 and case 4). These data support the utility of appropriate radiological investigation in GI-GVHD, paving the way for further serial and systematic investigations to track the appearance and evolution of GI damage in GVHD patients. Full article
(This article belongs to the Special Issue Crohn’s Disease and Ulcerative Colitis: Pathophysiology and New Therapeutic Strategies)
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