Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
5.2
3.9
Journals
Biomedicines
Special Issues
Major Breakthroughs in Diabetic Animal Model Research
share announcement

Major Breakthroughs in Diabetic Animal Model Research

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Endocrinology and Metabolism Research".

Deadline for manuscript submissions: closed (31 January 2024) | Viewed by 8377

Special Issue Editors

Dr. Magdalena Chottova Dvorakova

E-Mail Website
Guest Editor
Biomedical Center, Faculty of Medicine in Pilsen, Charles University, 323 00 Pilsen, Czech Republic
Interests: diabetic autonomic neuropathy; animal models; cardiac innervation; neuropeptides
Dr. Shashank Pandey

E-Mail Website
Guest Editor
Biomedical Center, Faculty of Medicine in Pilsen, Charles University, 323 00 Pilsen, Czech Republic
Interests: autoimmune disease; neuropeptides; proteomic biomarkers

Special Issue Information

Dear Colleagues,

Diabetes mellitus is one of the most significant global health emergencies of the 21st century. According to a statistical analysis conducted by International Diabetes Federation in 2017, 451 million adult people have diabetes worldwide, and this number is expected to reach 693 million by 2045. WHO claimed that it will be the seventh leading cause of death worldwide in 2030. For these reasons, it is necessary to pay great attention to research on the processes occurring in the diabetic organism. Although research into the pathophysiology of this disease has been ongoing for more than 100 years, no effective and reliable therapy has yet been found. Animal models of individual types of diabetes played, and still play, a significant role in this research.

The aim of this Special Issue is to collect the recent updates on the use of animal models in diabetes research, including, the description of hitherto undescribed pathological processes or new therapeutic options. We welcome original research and review articles.

Potential topics include, but are not limited to, the following:

  • Genetic or spontaneously induced animal models of type 1 or type 2 diabetes;
  • Nongenetic or experimentally induced animal models of type 1 or type 2 diabetes;
  • Animal models of gestational diabetes mellitus (GDM);
  • iPSC-based in vitro diabetic models;
  • Stem-cell-based organ-on-a-chip diabetic models;
  • Animal models of diabetic complications;
  • Future perspectives of modeling diabetes mellitus in animals;
  • Diabetic biomarkers;
  • Recent advances in treating diabetes and its complications from nonclinical studies;
  • Conventional and complementary approaches;
  • Vascular damage and regeneration.

Dr. Magdalena Chottova Dvorakova
Dr. Shashank Pandey
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • type 1 diabetes mellitus
  • type 2 diabetes mellitus
  • gestational diabetes
  • animal models
  • diabetic neuropathy
  • diabetic retinopathy
  • diabetic nephropathy
  • targeted therapy
  • stem cell technology

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (3 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

13 pages, 1812 KiB  
Article
The Glymphatic Response to the Development of Type 2 Diabetes
by Edward D. Boyd, Li Zhang, Guangliang Ding, Lian Li, Mei Lu, Qingjiang Li, Rui Huang, Jasleen Kaur, Jiani Hu, Michael Chopp, Zhenggang Zhang and Quan Jiang
Biomedicines 2024, 12(2), 401; https://doi.org/10.3390/biomedicines12020401 - 8 Feb 2024
Cited by 1 | Viewed by 1359
Abstract
The glymphatic system has recently been shown to be important in neurological diseases, including diabetes. However, little is known about how the progressive onset of diabetes affects the glymphatic system. The aim of this study is to investigate the glymphatic system response to [...] Read more.
The glymphatic system has recently been shown to be important in neurological diseases, including diabetes. However, little is known about how the progressive onset of diabetes affects the glymphatic system. The aim of this study is to investigate the glymphatic system response to the progressive onset of diabetes in a rat model of type 2 diabetic mellitus. Male Wistar rats (n = 45) with and without diabetes were evaluated using MRI glymphatic tracer kinetics, functional tests, and brain tissue immunohistochemistry. Our data demonstrated that the contrast agent clearance impairment gradually progressed with the diabetic duration. The MRI data showed that an impairment in contrast clearance occurred prior to the cognitive deficits detected using functional tests and permitted the detection of an early DM stage compared to the immuno-histopathology and cognitive tests. Additionally, the quantitative MRI markers of brain waste clearance demonstrated region-dependent sensitivity in glymphatic impairment. The improved sensitivity of MRI markers in the olfactory bulb and the whole brain at an early DM stage may be attributed to the important role of the olfactory bulb in the parenchymal efflux pathway. MRI can provide sensitive quantitative markers of glymphatic impairment during the progression of DM and can be used as a valuable tool for the early diagnosis of DM with a potential for clinical application. Full article
(This article belongs to the Special Issue Major Breakthroughs in Diabetic Animal Model Research)
►▼ Show Figures

Figure 1

Review

Jump to: Research

18 pages, 1425 KiB  
Review
Animal Models for Understanding the Mechanisms of Beta Cell Death during Type 2 Diabetes Pathogenesis
by Brittney A. Covington and Wenbiao Chen
Biomedicines 2024, 12(3), 473; https://doi.org/10.3390/biomedicines12030473 - 20 Feb 2024
Cited by 1 | Viewed by 2091
Abstract
Type 2 diabetes (T2D) has become a worldwide epidemic, primarily driven by obesity from overnutrition and sedentariness. Recent results reveal there is heterogeneity in both pathology and treatment responses in T2D patients. Therefore, a variety of T2D animal models are necessary to obtain [...] Read more.
Type 2 diabetes (T2D) has become a worldwide epidemic, primarily driven by obesity from overnutrition and sedentariness. Recent results reveal there is heterogeneity in both pathology and treatment responses in T2D patients. Therefore, a variety of T2D animal models are necessary to obtain a mechanistic understanding of distinct disease processes. T2D results from insufficient insulin, either due to beta cell loss or inborn deficiency. Although decreases in beta cell mass can occur through loss of identity or cell death, in this review, we will highlight the T2D animal models that display beta cell death, including the Zucker Diabetic Fatty Rat, sand rat, db/db mouse, and a novel diabetic zebrafish model, the Zebrafish Muscle Insulin-Resistant (zMIR) fish. Procuring a mechanistic understanding of different T2D progression trajectories under a variety of contexts is paramount for developing and testing more individualized treatments. Full article
(This article belongs to the Special Issue Major Breakthroughs in Diabetic Animal Model Research)
►▼ Show Figures

Figure 1

22 pages, 2425 KiB  
Review
Animal Models in Diabetic Research—History, Presence, and Future Perspectives
by Shashank Pandey, Tomas Chmelir and Magdalena Chottova Dvorakova
Biomedicines 2023, 11(10), 2852; https://doi.org/10.3390/biomedicines11102852 - 20 Oct 2023
Cited by 8 | Viewed by 4220
Abstract
Diabetes mellitus (DM) is a very serious disease, the incidence of which has been increasing worldwide. The beginning of diabetic research can be traced back to the 17th century. Since then, animals have been experimented on for diabetic research. However, the greatest development [...] Read more.
Diabetes mellitus (DM) is a very serious disease, the incidence of which has been increasing worldwide. The beginning of diabetic research can be traced back to the 17th century. Since then, animals have been experimented on for diabetic research. However, the greatest development of diabetes research occurred in the second half of the last century, along with the development of laboratory techniques. Information obtained by monitoring patients and animal models led to the finding that there are several types of DM that differ significantly from each other in the causes of the onset and course of the disease. Through different types of animal models, researchers have studied the pathophysiology of all types of diabetic conditions and discovered suitable methods for therapy. Interestingly, despite the unquestionable success in understanding DM through animal models, we did not fully succeed in transferring the data obtained from animal models to human clinical research. On the contrary, we have observed that the chances of drug failure in human clinical trials are very high. In this review, we will summarize the history and presence of animal models in the research of DM over the last hundred years. Furthermore, we have summarized the new methodological approaches, such as “organ-on-chip,” that have the potential to screen the newly discovered drugs for human clinical trials and advance the level of knowledge about diabetes, as well as its therapy, towards a personalized approach. Full article
(This article belongs to the Special Issue Major Breakthroughs in Diabetic Animal Model Research)
►▼ Show Figures

Graphical abstract

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-3
Back to TopTop