Research Advances in Kidney Diseases and Sepsis
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".
Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 1433
Special Issue Editor
Interests: sepsis; acute kidney injury; chronic kidney disease; hemodialysis therapy; diabetic nephropathy; aquaporin 2
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Sepsis and kidney diseases have a strong interrelationship, as they mutually increase the risk of one another. Kidney disease can contribute to the development of sepsis, particularly in individuals undergoing dialysis who possess a vascular access site such as a catheter, graft or fistula beneath their skin and within a blood vessel. This access point provides an avenue for pathogens to directly enter the bloodstream. Furthermore, chronic kidney disease can compromise the immune system's functionality, thereby elevating susceptibility to severe infections. Additionally, certain medications utilized post-kidney transplant surgery (such as anti-rejection drugs) may weaken the immune response. Infections can arise from kidney stones and potentially disseminate throughout the body, leading to sepsis. Sepsis can lead to systemic dysfunction, resulting in multi-organ failure, often initiating with renal impairment. Hypotension may ensue, leading to compromised perfusion of oxygen and nutrients to the kidneys. Additionally, intravascular coagulation can impede renal oxygenation. It is estimated that sepsis accounts for approximately one-third to one-half of cases involving acute kidney injury.
This Special Issue of Biomedicines will focus on sepsis and kidney disease via articles or reviews dealing with pathophysiology, diagnosis, biomarkers and treatment are welcome.
Dr. Eiichi Sato
Guest Editor
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Keywords
- sepsis
- acute kidney injury
- dialysis
- kidney failure
- immune system
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