Recent Advances in Understanding of the Role of Synuclein Family Members in Health and Disease: Third Edition
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Neurobiology and Clinical Neuroscience".
Deadline for manuscript submissions: 31 December 2024 | Viewed by 774
Special Issue Editor
Interests: neorodegeneration; mechanisms of proteinopaty; synuclein family; physiological functions of synucleins; chemical neurotransmission; dopamine; synucleinsynuclein-associated pathology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Extensive studies of α-synuclein function and dysfunction revealed its involvement in multiple normal and aberrant molecular processes and, consequently, various effects on the nervous system cell biology. However, certain other types of cells normally express this protein, and they may also be affected by α-synuclein dysfunction and thus contribute to pathological changes in α-synucleinopathies. It would be beneficial to summarize scattered data on these aspects of α-synuclein biology and pathology. Recent studies have drawn attention to the other two members of the family, b-synuclein and g-synuclein, whose role in homeostasis and pathology is still poorly understood. Three members of this family share many structural properties and have an overlapping pattern of expression and intracellular distribution in the developing and adult nervous systems, which points to functional redundancy within the family. However, each synuclein has its own functions unshared with two other synucleins, and in some cellular mechanisms and pathways, these functions could be antagonistic rather than synergistic.
This Special Issue aims to highlight the most recent research on both already well-known and emerging aspects of synuclein family biology and the role of the dysfunction of these proteins in neurodegenerative and other pathological conditions.
Dr. Natalia N. Ninkina
Guest Editor
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Keywords
- synuclein family
- alpha-synuclein
- beta-synuclein
- gamma-synuclein
- physiological functions of synucleins
- synucleins and lipids
- function of synucleins outside of the nervous system
- synuclein-associated pathology
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