Advances in Macrophage-Based Immunotherapy
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Immunology and Immunotherapy".
Deadline for manuscript submissions: 30 April 2025 | Viewed by 2505
Special Issue Editor
2. Centro de Investigación Biomédica en Red Enfermedades Hepáticas y Digestivas (CIBERehd), 46010 Valencia, Spain
Interests: macrophages; fibrosis; TGF; WNT; myofibroblasts; MMT; NOTCH; complications; succinate; autophagy; senescence; chronic inflammation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Adoptive cellular therapies are making major strides in the treatment of many diseases, especially in cancer and fibrosis. Amongst cell types used in immunotherapies, macrophages are prominent candidates. Macrophages have critical functions in both innate and adaptive immune responses. They are present in almost every tissue, recognize exogenous/endogenous danger signals through pattern-recognition receptors, produce cytokines/chemokines that orchestrate immune responses, function as professional antigen-presenting cells, and are important elements in wound repair and fibrosis by regulating extracellular matrix turnover. The diversity of functions they perform is due to the fact that their phenotype is highly plastic and exists across a spectrum of pro- and anti-inflammatory states. Plasticity allows participating in numerous effector functions that could support chronic autoimmune diseases, tumor, or fibrosis clearance. The Special Issue “Advanced in Macrophage-Based Immunotherapy” aims to collect information on the use of cell therapy in different pathologies, with a special interest in therapy that uses reprogrammed macrophages capable of limiting the pathology by modifying the microenvironment, favoring the cleaning of cancer and fibrotic cells or promoting regeneration, among other processes.
Prof. Dr. Dolores Ortiz-Masiá
Guest Editor
Manuscript Submission Information
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Keywords
- macrophages
- fibrosis
- cancer
- chronic inflammation
- autophagy
- apoptosis
- senescence
- immunotherapy
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