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Biomedicines
Special Issues
Advances in 3D Printing and Biomaterials in Tissue Engineering
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Advances in 3D Printing and Biomaterials in Tissue Engineering

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Biomedical Engineering and Materials".

Deadline for manuscript submissions: closed (30 September 2024) | Viewed by 12405

Special Issue Editor

Dr. Olatunji Ajiteru

E-Mail Website
Guest Editor
Nano-Bio Regenerative Medical Institute, College of Medicine, Hallym University, 1 Hallymdaehak-gil, Chuncheon 24252, Republic of Korea
Interests: biomaterial fabrication; 3D bioprinting; natural hydrogels; tissue engineering; wound healing

Special Issue Information

Dear Colleagues,

Tissue engineering is a cutting-edge field of biomedical research that has shown great promise in overcoming the challenges of organ shortages and degenerative diseases. Central to its success are the remarkable strides made in 3D printing technology and antecedent biomaterial fabrications. The convergence of these two has propelled tissue engineering and regenerative medicine to new heights.

The aim of this Special Issue is to present a comprehensive collection of cutting-edge research, innovative techniques, and insightful studies that highlight the significant progress made in the field of 3D printing and biomaterial fabrications. The scope of the Issue includes but is not limited to advances in 3D printing technology and methodologies, novel biomaterials and their synthesis for 3D printing applications, bioprinting and tissue engineering using 3D printing techniques, 3D-printed medical devices and implants, 3D printing in drug delivery systems and pharmaceutical research, biofabrication and organ-on-a-chip technologies, biocompatibility and bio-functionalities assessment of biomaterials for tissue regeneration and wound healing.

Dr. Olatunji Ajiteru
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • 3D printing
  • biomaterials
  • tissue engineering
  • organ-on-a-chip
  • scaffolding
  • bioinks
  • biofabrication
  • wound healing
  • organ mimicry

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Published Papers (5 papers)

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15 pages, 13327 KiB  
Article
Turning Portunus pelagicus Shells into Biocompatible Scaffolds for Bone Regeneration
by Louisa Candra Devi, Hendrik Satria Dwi Putra, Nyoman Bayu Wisnu Kencana, Ajiteru Olatunji and Agustina Setiawati
Biomedicines 2024, 12(8), 1796; https://doi.org/10.3390/biomedicines12081796 - 7 Aug 2024
Viewed by 863
Abstract
Bone tissue engineering (BTE) provides an alternative for addressing bone defects by integrating cells, a scaffold, and bioactive growth factors to stimulate tissue regeneration and repair, resulting in effective bioengineered tissue. This study focuses on repurposing chitosan from blue swimming crab (Portunus [...] Read more.
Bone tissue engineering (BTE) provides an alternative for addressing bone defects by integrating cells, a scaffold, and bioactive growth factors to stimulate tissue regeneration and repair, resulting in effective bioengineered tissue. This study focuses on repurposing chitosan from blue swimming crab (Portunus pelagicus) shell waste as a composite scaffold combined with HAP and COL I to improve biocompatibility, porosity, swelling, and mechanical properties. The composite scaffold demonstrated nearly 60% porosity with diameters ranging from 100–200 μm with an interconnected network that structurally mimics the extracellular matrix. The swelling ratio of the scaffold was measured at 208.43 ± 14.05%, 248.93 ± 4.32%, 280.01 ± 1.26%, 305.44 ± 20.71%, and 310.03 ± 17.94% at 1, 3, 6, 12, and 24 h, respectively. Thus, the Portunus pelagicus scaffold showed significantly lower degradation ratios of 5.64 ± 1.89%, 14.34 ± 8.59%, 19.57 ± 14.23%, and 29.13 ± 9.87% for 1 to 4 weeks, respectively. The scaffold supports osteoblast attachment and proliferation for 7 days. Waste from Portunus pelagicus shells has emerged as a prospective source of chitosan with potential application in tissue engineering. Full article
(This article belongs to the Special Issue Advances in 3D Printing and Biomaterials in Tissue Engineering)
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13 pages, 12717 KiB  
Article
Workflow for Maxilla/Mandible Individual [Mai®] Implant by Integra Implants—How Individual Implants Are Manufactured
by Rafał Zieliński, Agata Kołkowska, Jerzy Sowiński, Bartłomiej Konieczny, Marcin Kozakiewicz and Wojciech Simka
Biomedicines 2024, 12(8), 1773; https://doi.org/10.3390/biomedicines12081773 - 6 Aug 2024
Viewed by 806
Abstract
The newest technology allows the medical industry to manufacture innovative products such as milled titanium prosthodontic parts in an implant for a screw-retained suprastructure. In the literature, there are some articles on the clinical usage of subperiosteal implants, but none of these publications, [...] Read more.
The newest technology allows the medical industry to manufacture innovative products such as milled titanium prosthodontic parts in an implant for a screw-retained suprastructure. In the literature, there are some articles on the clinical usage of subperiosteal implants, but none of these publications, either in PubMed or Google Scholar, thoroughly describe the workflow for the design and manufacture of individual implants for maxillofacial surgery with milled threads for a screw-retained prosthodontic bridge. The aim of the article is to present a step-by-step method of producing personalized implants, from the first steps of production to the implantation of the final product. The article includes information on patient qualification for surgery, computational preparation and skull printing, planning of Mai Implants®, meshing, 3D printing and milling, cleaning, rinsing, anodizing, and laser marking, as well as the cleaning and sterilization process in a hospital or dental clinic. A detailed description of implant production allows for the analysis of each step and the development of technology. The production of implants is an expensive procedure, but considering all the advantages of the Mai Implants® treatment and the disadvantages of alternatives, the product is worth the price. Full article
(This article belongs to the Special Issue Advances in 3D Printing and Biomaterials in Tissue Engineering)
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24 pages, 26504 KiB  
Article
Mechanical and Material Analysis of 3D-Printed Temporary Materials for Implant Reconstructions—A Pilot Study
by Adam Nowicki, Karolina Osypko, Adam Kurzawa, Maciej Roszak, Karina Krawiec and Dariusz Pyka
Biomedicines 2024, 12(4), 870; https://doi.org/10.3390/biomedicines12040870 - 15 Apr 2024
Cited by 2 | Viewed by 6639
Abstract
In this study, the authors analyzed modern resin materials typically used for temporary reconstructions on implants and manufactured via 3D printing. Three broadly used resins: NextDent Denture 3D, NextDent C&B MFH Bleach, and Graphy TC-80DP were selected for analysis and compared to currently [...] Read more.
In this study, the authors analyzed modern resin materials typically used for temporary reconstructions on implants and manufactured via 3D printing. Three broadly used resins: NextDent Denture 3D, NextDent C&B MFH Bleach, and Graphy TC-80DP were selected for analysis and compared to currently used acrylic materials and ABS-like resin. In order to achieve this, mechanical tests were conducted, starting with the static tensile test PN-EN. After the mechanical tests, analysis of the chemical composition was performed and images of the SEM microstructure were taken. Moreover, numerical simulations were conducted to create numerical models of materials and compare the accuracy with the tensile test. The parameters obtained in the computational environment enabled more than 98% correspondence between numerical and experimental charts, which constitutes an important step towards the further development of numeric methods in dentistry and prosthodontics. Full article
(This article belongs to the Special Issue Advances in 3D Printing and Biomaterials in Tissue Engineering)
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18 pages, 5813 KiB  
Article
Integrating Fused Deposition Modeling and Melt Electrowriting for Engineering Branched Vasculature
by Quinn S. Thorsnes, Paul R. Turner, Mohammed Azam Ali and Jaydee D. Cabral
Biomedicines 2023, 11(12), 3139; https://doi.org/10.3390/biomedicines11123139 - 24 Nov 2023
Cited by 2 | Viewed by 2067
Abstract
We demonstrate for the first time the combination of two additive manufacturing technologies used in tandem, fused deposition modelling (FDM) and melt electrowriting (MEW), to increase the range of possible MEW structures, with a focus on creating branched, hollow scaffolds for vascularization. First, [...] Read more.
We demonstrate for the first time the combination of two additive manufacturing technologies used in tandem, fused deposition modelling (FDM) and melt electrowriting (MEW), to increase the range of possible MEW structures, with a focus on creating branched, hollow scaffolds for vascularization. First, computer-aided design (CAD) was used to design branched mold halves which were then used to FDM print conductive polylactic acid (cPLA) molds. Next, MEW was performed over the top of these FDM cPLA molds using polycaprolactone (PCL), an FDA-approved biomaterial. After the removal of the newly constructed MEW scaffolds from the FDM molds, complementary MEW scaffold halves were heat-melded together by placing the flat surfaces of each half onto a temperature-controlled platform, then pressing the heated halves together, and finally allowing them to cool to create branched, hollow constructs. This hybrid technique permitted the direct fabrication of hollow MEW structures that would otherwise not be possible to achieve using MEW alone. The scaffolds then underwent in vitro physical and biological testing. Specifically, dynamic mechanical analysis showed the scaffolds had an anisotropic stiffness of 1 MPa or 5 MPa, depending on the direction of the applied stress. After a month of incubation, normal human dermal fibroblasts (NHDFs) were seen growing on the scaffolds, which demonstrated that no deleterious effects were exerted by the MEW scaffolds constructed using FDM cPLA molds. The significant potential of our hybrid additive manufacturing approach to fabricate complex MEW scaffolds could be applied to a variety of tissue engineering applications, particularly in the field of vascularization. Full article
(This article belongs to the Special Issue Advances in 3D Printing and Biomaterials in Tissue Engineering)
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8 pages, 2608 KiB  
Case Report
Tibia Valga Correction by Extraperiosteal Fibular Release in Multiple Exostosis Disease
by Adyb-Adrian Khal, Emilie Peltier, Elie Choufani, Jean-Marc Guillaume, Franck Launay, Jean-Luc Jouve and Sébastien Pesenti
Biomedicines 2023, 11(10), 2841; https://doi.org/10.3390/biomedicines11102841 - 19 Oct 2023
Cited by 1 | Viewed by 1136
Abstract
Genu valgum is a frequent deformity encountered in Multiple Hereditary Exostosis (MHE) patients. If left untreated, lower limb deformity leads to poor functional outcomes in adulthood. Our hypothesis was that in some cases, fibular shortening would lead to a lateral epiphysiodesis-like effect on [...] Read more.
Genu valgum is a frequent deformity encountered in Multiple Hereditary Exostosis (MHE) patients. If left untreated, lower limb deformity leads to poor functional outcomes in adulthood. Our hypothesis was that in some cases, fibular shortening would lead to a lateral epiphysiodesis-like effect on the tibia. We herein report the case of a 6-year-old child with MHE who underwent extraperiosteal resection of the fibula for tibia valga correction. To obtain the lateral release of the calf skeleton, resection included inter-tibio-fibular exostosis along with proximal fibular metaphysis and diaphysis without any osseous procedure on the tibia. Gradual improvement of the valgus deformity occurred during follow-up (HKA from 165° preop to 178° at 27-month follow-up). Lateral release of the fibula led to an increase in the fibula/tibia index (from 93% preop to 96% at follow-up). Studying fibular growth in MHE patients could help understand how valgus deformity occurs in these patients. Even if encouraging, this result is just the report of a unique case. Further research and a larger series of patients are required to assess fibular release as a valuable option to treat valgus deformity in MHE. Full article
(This article belongs to the Special Issue Advances in 3D Printing and Biomaterials in Tissue Engineering)
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