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Biomedicines
Special Issues
Inorganic Phosphate Homeostasis and Signaling in Eukaryotic Cells
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Inorganic Phosphate Homeostasis and Signaling in Eukaryotic Cells

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".

Deadline for manuscript submissions: closed (30 September 2022) | Viewed by 9260

Special Issue Editors

Dr. Nima Abbasian

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Guest Editor
Domainex Ltd, Unit 2, Iconix Park, London Road, Pampisford, Cambridge, CB22 3EG, UK
Interests: inorganic phosphate; cell signaling; phosphate-sensitive enzymes; cytoskeleton; microvesicles; thrombosis
Dr. Alan Bevington

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Guest Editor
Biochemistry (Renal Medicine), University of Leicester, Leicester, UK
Interests: inorganic phosphate; orthophosphate; phosphate sensing; phosphate-sensitive enzymes; phosphate transport

Special Issue Information

Dear Colleagues,

Present in animals’ cells, protozoa, fungi, and plants, inorganic phosphate (Pi) is involved in regulating a wide range of fundamental cellular processes, including energy homeostasis; nucleotide, nucleic acid, and phospholipid metabolism; and signaling through protein phosphorylation events. There is now vast evidence that Pi is associated with major pathological processes, including increased thrombotic risk in chronic kidney disease (CKD), renal fibrosis, angiogenesis, carcinogenesis, and tumor progression, but cellular and molecular mechanisms involved in regulating cellular Pi homeostasis and sensing changes in the extracellular and intracellular Pi concentrations are still elusive and merit further investigations. This Special Issue invites expertise in the field relating to cellular Pi homeostasis and signaling in eukaryotic cells with an overall aim to collate advanced knowledge around the field for a better and clearer understanding of cellular Pi sensing, signaling, and pathologies which may arise from anomalies in cellular Pi homeostasis. This Special Issue welcomes original research articles, reviews, communications, and concept papers focused on Pi homeostasis and signaling in eukaryotic cells. We also welcome submissions shedding light on the role of Pi in cell to cell or species to species interactions.

Dr. Nima Abbasian
Dr. Alan Bevington
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • phosphate
  • signaling
  • phosphate transporters
  • phosphate sensing
  • eukaryotic cells
  • phosphate homeostasis

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Published Papers (2 papers)

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Review

15 pages, 2061 KiB  
Review
Inorganic Polyphosphate—Regulator of Cellular Metabolism in Homeostasis and Disease
by Filip Kus, Ryszard T. Smolenski and Marta Tomczyk
Biomedicines 2022, 10(4), 913; https://doi.org/10.3390/biomedicines10040913 - 15 Apr 2022
Cited by 10 | Viewed by 3724
Abstract
Inorganic polyphosphate (polyP), a simple anionic polymer consisting of even hundreds of orthophosphate units, is a universal molecule present in both simple and complex organisms. PolyP controls homeostatic processes in animals, such as blood coagulation, tissue regeneration, and energy metabolism. Furthermore, this polymer [...] Read more.
Inorganic polyphosphate (polyP), a simple anionic polymer consisting of even hundreds of orthophosphate units, is a universal molecule present in both simple and complex organisms. PolyP controls homeostatic processes in animals, such as blood coagulation, tissue regeneration, and energy metabolism. Furthermore, this polymer is a potent regulator of inflammation and influences host immune response in bacterial and viral infections. Disturbed polyP systems have been related to several pathological conditions, including neurodegeneration, cardiovascular disorders, and cancer, but we lack a full understanding of polyP biogenesis and mechanistic insights into the pathways through which polyP may act. This review summarizes recent studies that describe the role of polyP in cell homeostasis and show how disturbances in polyP levels may lead to disease. Based on the collected findings, we highlight the possible usage of this polymer as a promising therapeutic tool in multiple pathologies. Full article
(This article belongs to the Special Issue Inorganic Phosphate Homeostasis and Signaling in Eukaryotic Cells)
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12 pages, 787 KiB  
Review
Vascular Calcification Mechanisms: Updates and Renewed Insight into Signaling Pathways Involved in High Phosphate-Mediated Vascular Smooth Muscle Cell Calcification
by Nima Abbasian
Biomedicines 2021, 9(7), 804; https://doi.org/10.3390/biomedicines9070804 - 12 Jul 2021
Cited by 29 | Viewed by 4731
Abstract
Vascular calcification (VC) is associated with aging, cardiovascular and renal diseases and results in poor morbidity and increased mortality. VC occurs in patients with chronic kidney disease (CKD), a condition that is associated with high serum phosphate (Pi) and severe cardiovascular consequences. High [...] Read more.
Vascular calcification (VC) is associated with aging, cardiovascular and renal diseases and results in poor morbidity and increased mortality. VC occurs in patients with chronic kidney disease (CKD), a condition that is associated with high serum phosphate (Pi) and severe cardiovascular consequences. High serum Pi level is related to some pathologies which affect the behaviour of vascular cells, including platelets, endothelial cells (ECs) and smooth muscle cells (SMCs), and plays a central role in promoting VC. VC is a complex, active and cell-mediated process involving the transdifferentiation of vascular SMCs to a bone-like phenotype, systemic inflammation, decreased anti-calcific events (loss of calcification inhibitors), loss in SMC lineage markers and enhanced pro-calcific microRNAs (miRs), an increased intracellular calcium level, apoptosis, aberrant DNA damage response (DDR) and senescence of vascular SMCs. This review gives a brief overview of the current knowledge of VC mechanisms with a particular focus on Pi-induced changes in the vascular wall important in promoting calcification. In addition to reviewing the main findings, this review also sheds light on directions for future research in this area and discusses emerging pathways such as Pi-regulated intracellular calcium signaling, epigenetics, oxidative DNA damage and senescence-mediated mechanisms that may play critical, yet to be explored, regulatory and druggable roles in limiting VC. Full article
(This article belongs to the Special Issue Inorganic Phosphate Homeostasis and Signaling in Eukaryotic Cells)
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