Advanced Research on Skeletal Muscle Metabolism

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: closed (31 January 2025) | Viewed by 813

Special Issue Editor


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Guest Editor
Department of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, Italy
Interests: musculoskeletal system; osteoporosis; sarcopenia; osteosarcopenia; musculoskeletal disease; aging; myokine
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Special Issue Information

Dear Colleagues,

Skeletal muscles are used for locomotion and other physical tasks and are able to produce myokines by functioning as an endocrine organ. Moreover, skeletal muscle can regulate the metabolism of the entire body. The structure, properties, and volume of skeletal muscles are related to human health, longevity, and quality of life. Currently, skeletal muscle metabolism is an important area of research because of its profound implications on human health and disease. Research in this area includes exploring the molecular mechanisms that regulate muscle homeostasis, the role of muscle metabolism on human health, and adaptations of muscle tissue in response to exercise and nutritional interventions. Areas of interest in this Special Issue include the identification and function of metabolic pathways, the impact of genetic and epigenetic factors, and the interaction between muscle and other tissues. In this Special Issue, we look forward to original research and reviews that highlight recent advances in research in muscle metabolism from both physiological and pathophysiological perspectives.

Dr. Lorenzo Sanesi
Guest Editor

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Keywords

  • energy metabolism
  • mebabolic signaling pathways
  • homeostasis
  • myokines
  • aging
  • atrophy
  • muscle metabolism

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Published Papers (1 paper)

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Research

8 pages, 755 KiB  
Communication
Cell Mechanisms of Post-Mortem Excitability of Skeletal Muscle
by H. Stigter, T. Krap and W. L. J. M. Duijst
Biomedicines 2025, 13(1), 221; https://doi.org/10.3390/biomedicines13010221 - 17 Jan 2025
Viewed by 527
Abstract
Background/Objectives: The excitability of skeletal muscle is a less-known post-mortem supravital phenomenon in human bodies, and it can be used to estimate the post-mortem interval. We conducted a field study in the Netherlands to investigate the applicability of muscle excitability (SMR) by mechanical [...] Read more.
Background/Objectives: The excitability of skeletal muscle is a less-known post-mortem supravital phenomenon in human bodies, and it can be used to estimate the post-mortem interval. We conducted a field study in the Netherlands to investigate the applicability of muscle excitability (SMR) by mechanical stimulation for estimating the post-mortem interval in daily forensic practice. Knowledge concerning the post-mortem cell mechanisms accounting for the post-mortem excitability of skeletal muscle is lacking. Cell mechanisms are the specific intracellular and biochemical processes responsible for post-mortem muscle excitability. Methods: We have studied the theoretical backgrounds of the cell mechanisms that might be responsible for post-mortem muscle excitability, by performing literature research via the databank PubMed. Results: Based on the current available literature, in our opinion the intracellular changes in muscle cells that are responsible for SMR resemble the intracellular processes responsible for muscle fatigue due to energy exhaustion in the living. Conclusions: We hypothesize two pathways, depending on the level of energy in the muscle cell, that could be responsible for post-mortem muscle excitability by mechanical stimulation. Full article
(This article belongs to the Special Issue Advanced Research on Skeletal Muscle Metabolism)
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