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Biomedicines
Special Issues
Innovations and Translational Approaches in Stroke Research
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Innovations and Translational Approaches in Stroke Research

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: 30 November 2024 | Viewed by 3844

Special Issue Editors

Dr. Ștefan Strilciuc

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Guest Editor
Research Center for Functional Genomics, Biomedicine and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400015 Cluj-Napoca, Romania
Interests: functional genomics; personalized medicine; neurological disorders
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Dafin Fior Mureşanu

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Guest Editor
Department of Neurosciences, Iuliu Hațieganu University of Medicine and Pharmacy, No. 8 Victor Babeș Street, 400012 Cluj-Napoca, Romania
Interests: cerebrovascular diseases; neurodegenerative diseases; traumatic brain injury; brain protection and recovery; neurorehabilitation; neuroimmunology; ischemic stroke; neuropharmacology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The realm of stroke research has witnessed significant advancements in recent decades, particularly in understanding pathogenesis and treatment strategies, leading to improved patient outcomes in some care settings. Nevertheless, more progress is needed to address the immense burden of cerebrovascular diseases around the world. Our Special Issue aims to accommodate a broad spectrum of topics; including novel pathogenesis mechanisms that underlie these acute conditions; translational research; a pivotal bridge between basic science findings and their clinical applications; the role of biomaterials in stroke research, especially those that promote neurorestoration; and the discovery of specific biomarkers and diagnostic methods for stroke. The world of neuropharmacology is buzzing with innovative drug discoveries and developments, all aimed at the prevention and treatment of stroke. We therefore also welcome contributions on biopharmaceutical approaches that span biologics, biosimilars, and nanobiotechnological innovations in stroke therapy, from targeted nanomedicine, nano-scaffolding, and biosensors to gene and cell therapy. We invite authors to contribute their research and insights, helping to shape our understanding of stroke.

Dr. Ștefan Strilciuc
Prof. Dr. Dafin Fior Mureşanu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • acute ischemic stroke
  • hemorrhagic stroke
  • translational research
  • biomaterials in stroke
  • stroke diagnosis
  • drug development for stroke
  • biopharmaceutical approaches
  • nanobiotechnology in stroke therapy
  • gene and cell therapy
  • nano-scaffolding

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Published Papers (3 papers)

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12 pages, 1066 KiB  
Article
Serum Adiponectin Levels Increase in Acute Ischemic Stroke and Correlate with Patients’ Outcomes: A Pilot Study
by Andrei-Lucian Zaharia, Violeta Diana Oprea, Camelia Alexandra Coadă, Claudiu Elisei Tănase, Ana-Maria Ionescu, Sergiu Ioachim Chirila, Raul Mihailov, Dana Tutunaru and Mihaiela Lungu
Biomedicines 2024, 12(8), 1828; https://doi.org/10.3390/biomedicines12081828 - 12 Aug 2024
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Abstract
Stroke is a leading cause of death and severe disability worldwide. Rapid diagnosis is critical to ensure the timely administration of medical treatment. Given that in some cases CT scans fail to show the classic clinical signs of stroke, we aimed to evaluate [...] Read more.
Stroke is a leading cause of death and severe disability worldwide. Rapid diagnosis is critical to ensure the timely administration of medical treatment. Given that in some cases CT scans fail to show the classic clinical signs of stroke, we aimed to evaluate the diagnostic capacity of adiponectin levels and their association with the clinical parameters of patients with acute ischemic stroke (AIS). Adiponectin was measured within 24 h (T1) and 48 h (T2) of AIS onset in 70 patients. A total of 68 control cases were included in the study. Adiponectin levels were significantly higher in the AIS patients than in the controls (16.64 (3.79; 16.69) vs. 3.78 (3.79; 16.69); p < 0.001), with an accuracy of 0.98 (AUC = 0.99). Lower levels were seen in males and in AIS patients with obesity. Higher levels of adiponectin at T1 were associated with a moderate/severe NIHSS score at patient discharge. Moreover, higher levels of borderline significance were seen in patients who died within 12 months of their AIS episode (p = 0.054). Adiponectin may be a useful biomarker for the identification of AIS patients who do not present classic CT signs and could be used to stratify severe cases. Further studies are needed to validate these results. Full article
(This article belongs to the Special Issue Innovations and Translational Approaches in Stroke Research)
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13 pages, 528 KiB  
Article
Memory-Guided Saccades in Subacute and Chronic Stroke: Secondary Data Analysis of the N-PEP-12 Clinical Study
by Emanuel Ștefănescu, Maria Balea, Vlad-Florin Chelaru, Nicoleta Jemna, Olivia Verișezan Roșu, Anamaria Truță, Adina Dora Stan, Diana Chira, Ștefan Strilciuc and Dafin Mureșanu
Biomedicines 2024, 12(8), 1678; https://doi.org/10.3390/biomedicines12081678 - 26 Jul 2024
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Abstract
Background: Ischemic stroke (IS) often leads to cognitive and motor impairments. This study aimed to investigate whether Memory-Guided Saccade Tasks (MGSTs) could be used to assess cognitive function in stroke patients. Methods: A secondary data analysis was conducted on 62 individuals with supratentorial [...] Read more.
Background: Ischemic stroke (IS) often leads to cognitive and motor impairments. This study aimed to investigate whether Memory-Guided Saccade Tasks (MGSTs) could be used to assess cognitive function in stroke patients. Methods: A secondary data analysis was conducted on 62 individuals with supratentorial IS. Eye-tracking metrics from MGST were correlated with established neuropsychological assessments, including the Montreal Cognitive Assessment (MoCA) and Hospital Anxiety and Depression Scale (HADS). Results: Age correlated negatively with memory-guided saccade (MGS) accuracy (ρ = −0.274) and positively with late errors (ρ = 0.327). Higher Montreal Cognitive Assessment (MoCA) scores were associated with faster corrective saccades (ρ = 0.259). Increased anxiety (HADS-A) and depression (HADS-D) levels correlated with higher early error rates (ρ = 0.325 and ρ = 0.311, respectively). The Color Trails Test and Digit Span test performance also correlated with various MGS parameters. Conclusions: While some correlations were found between cognitive measures and eye-tracking metrics, further research is needed to validate MGST as a tool for cognitive assessment in a more homogenous stroke population. Full article
(This article belongs to the Special Issue Innovations and Translational Approaches in Stroke Research)
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13 pages, 976 KiB  
Article
Intravenous Thrombolysis in Posterior versus Anterior Circulation Stroke: Clinical Outcome Differs Only in Patients with Large Vessel Occlusion
by Simona Halúsková, Roman Herzig, Robert Mikulík, Silvie Bělašková, Martin Reiser, Lubomír Jurák, Daniel Václavík, Michal Bar, Lukáš Klečka, Tomáš Řepík, Vladimír Šigut, Aleš Tomek, David Hlinovský, Daniel Šaňák, Oldřich Vyšata, Martin Vališ and on behalf of the Czech SITS Investigators
Biomedicines 2024, 12(2), 404; https://doi.org/10.3390/biomedicines12020404 - 9 Feb 2024
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Abstract
The safety and efficacy of intravenous thrombolysis (IVT) are well established in anterior circulation stroke (ACS) but are much less clear for posterior circulation stroke (PCS). The aim of this study was to evaluate the occurrence of parenchymal hematoma (PH) and 3-month clinical [...] Read more.
The safety and efficacy of intravenous thrombolysis (IVT) are well established in anterior circulation stroke (ACS) but are much less clear for posterior circulation stroke (PCS). The aim of this study was to evaluate the occurrence of parenchymal hematoma (PH) and 3-month clinical outcomes after IVT in PCS and ACS. In an observational, cohort multicenter study, we analyzed data from ischemic stroke patients treated with IVT prospectively collected in the SITS (Safe Implementation of Treatments in Stroke) registry in the Czech Republic between 2004 and 2018. Out of 10,211 patients, 1166 (11.4%) had PCS, and 9045 (88.6%) ACS. PH was less frequent in PCS versus ACS patients: 3.6 vs. 5.9%, odds ratio (OR) = 0.594 in the whole set, 4.4 vs. 7.8%, OR = 0.543 in those with large vessel occlusion (LVO), and 2.2 vs. 4.7%, OR = 0.463 in those without LVO. At 3 months, PCS patients compared with ACS patients achieved more frequently excellent clinical outcomes (modified Rankin scale [mRS] 0–1: 55.5 vs. 47.6%, OR = 1.371 in the whole set and 49.2 vs. 37.6%, OR = 1.307 in those with LVO), good clinical outcomes (mRS 0–2: 69.9 vs. 62.8%, OR = 1.377 in the whole set and 64.5 vs. 50.5%, OR = 1.279 in those with LVO), and had lower mortality (12.4 vs. 16.6%, OR = 0.716 in the whole set and 18.4 vs. 25.5%, OR = 0.723 in those with LVO) (p < 0.05 in all cases). In PCS versus ACS patients, an extensive analysis showed a lower risk of PH both in patients with and without LVO, more frequent excellent and good clinical outcomes, and lower mortality 3 months after IVT in patients with LVO. Full article
(This article belongs to the Special Issue Innovations and Translational Approaches in Stroke Research)
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