Novel Pharmacological Strategies in the Treatment and Prevention of Acute Ischemic Stroke

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 3866

Special Issue Editors


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Guest Editor
Department of Emergency Medicine, Internal and Sub-Intensive Medicine, Azienda Ospedaliero-Universitaria "Ospedali Riuniti", 60166 Ancona, Italy
Interests: Alzheimer's disease; neurodegeneration; vascular disease; acute care; critically ill patient
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Guest Editor
Neurological Clinic, Department of Experimental and Clinical Medicine, Marche Polytechnic University, Ancona, Italy
Interests: stroke; cognitive impairment; dementia; carotid ultrasound; migraine; headache
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Special Issue Information

Dear Colleagues,

In recent years, treatment of acute ischemic stroke has seen a significant improvement thanks to both pharmacological and technological developments. Patients benefited greatly from an overall improvement in preventive strategies with newer anti-hypertensive and lipid-lowering drugs, direct oral anticoagulants, and more effective antiplatelet regimens that reduced the number of severe ischemic strokes. Moreover, newer combined strategies, such as fibrinolysis with sequential thrombectomy performed by better defining damaged areas with perfusion CT scan or MRI, resulted in overall improved functional outcomes.

In this Special Issue, we are interested in basic and translational research papers regarding the physiological, molecular, and clinical effects of newer pharmacological approaches in the context of preventive strategies or treatment of acute ischemic stroke. Both original articles and review papers will be considered for publication in this Special Issue of Biomedicines.

Dr. Lorenzo Falsetti
Dr. Giovanna Viticchi
Guest Editors

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Published Papers (1 paper)

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Research

9 pages, 1657 KiB  
Article
In Vitro Blood Clot Formation and Dissolution for Testing New Stroke-Treatment Devices
by Kayla Wood, Sam E. Stephens, Feng Xu, Alshaimaa Hazaa, James C. Meek, Hanna K. Jensen, Morten O. Jensen and Ranil Wickramasinghe
Biomedicines 2022, 10(8), 1870; https://doi.org/10.3390/biomedicines10081870 - 3 Aug 2022
Cited by 7 | Viewed by 3264
Abstract
Strokes are among the leading causes of death worldwide. Ischemic stroke, due to plaque or other buildup blocking blood flow to the brain, is the most common type. Although ischemic stroke is treatable, current methods have severe shortcomings with high mortality rates. Clot [...] Read more.
Strokes are among the leading causes of death worldwide. Ischemic stroke, due to plaque or other buildup blocking blood flow to the brain, is the most common type. Although ischemic stroke is treatable, current methods have severe shortcomings with high mortality rates. Clot retrieval devices, for example, can result in physically damaged vessels and death. This study aims to create blood clots that are representative of those found in vivo and demonstrate a new method of removing them. Static blood clots were formed using a 9:1 ratio of whole sheep blood and 2.45% calcium chloride solution. This mixture was heated in a water bath at 37 °C for approximately one hour until solidified. Following clot solidification, human plasmin was introduced by various methods, including soaking, injection, and membrane perfusion, and the resulting dissolution percentages were determined. Different clot types, representative of the wide range found physiologically, were also manufactured and their dissolution characteristics evaluated. A method to reproducibly create blood clots, characteristic of those found in vivo, is essential for the production of stroke retrieval devices that can efficiently and effectively remove clots from patients with low mortality rates and little/no damage to the surrounding vessels. Full article
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