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Biomedicines
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Advances in Adipogenesis and Adipose Tissue Metabolism
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Advances in Adipogenesis and Adipose Tissue Metabolism

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Endocrinology and Metabolism Research".

Deadline for manuscript submissions: closed (31 July 2022) | Viewed by 6751

Special Issue Editor

Prof. Dr. Yih-Hsin Chang

E-Mail Website
Guest Editor
Department of Biotechnology and Laboratory Science in Medicine, National Yang Ming Chiao Tung University, No. 155, Sec. 2, Linong St., Beitou District, Taipei 112, Taiwan
Interests: obesity; metabolism; diabetes mellitus; related disorders

Special Issue Information

Dear Colleagues,

Obesity is the major risk factor leading to metabolic syndrome, type 2 diabetes mellitus (T2DM) and diabetic complications. Obesity has become an epidemic problem globally, affecting persons of all ages in both developed and developing countries. In 2014, World Health Organization reported that 39% (more than 1.9 billion) and 13% (600 million) among the adults were overweight and obese, respectively. This worldwide obesity epidemic leads to the consistently increasing incidence and prevalence of T2DM.

Obesity and T2DM are closely associated with chronic inflammation. Accumulating evidence had shown that long-term hypersecretion of cytokines may impair insulin secretion, induce hypertriglyceridaemia and insulin resistance. Accordingly, immune response and inflammation participate in the complex inter-organ communication network modulating metabolism and energy homeostasis, and therefore, involve in the pathological evolution from metabolic imbalance, obesity to the closely associated disorders.

We invite investigators to contribute original research as well as review articles addressing recent advances on the involvement of immune responses and the networks among immune responses and metabolic organs in maintaining energy homeostasis and in the pathological process of metabolic imbalance to diseases. Original, high quality contributions that are not yet published or that are not currently under review by other journals or peer-reviewed conferences are sought.

Potential topics include, but are not limited to:

  • Inflammation and immune responses in metabolism and related disorders
  • Chemokines and cytokines in metabolism and related disorders
  • Immunology of metabolism and related disorders
  • Models of metabolism and related disorders
  • Immunotherapy in metabolism and related disorders

Prof. Dr. Yih-Hsin Chang
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

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Published Papers (3 papers)

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Research

16 pages, 4336 KiB  
Article
Implication of Adipogenesis-Coupled CRMP2 Functional Profile in Metabolic Homeostasis and Imbalance
by Yih-Hsin Chang, Shu-Wen Chang, Wei-Ting Hsu, Ching-Ping Yang, Yu-Li Lo, Chun-Jung Chen, Hui-Fang Tsai and Ming-Yuh Shiau
Biomedicines 2022, 10(10), 2603; https://doi.org/10.3390/biomedicines10102603 - 17 Oct 2022
Viewed by 1586
Abstract
Our previous studies demonstrated that collapsin response mediator protein 2 (CRMP2) is associated with obesity and, in addition, that hyperglycemia-suppressed CRMP2 augments malignant traits of colorectal cancer and is associated with advanced tumor stage. Regulation of CRMP2 profile was further explored in this [...] Read more.
Our previous studies demonstrated that collapsin response mediator protein 2 (CRMP2) is associated with obesity and, in addition, that hyperglycemia-suppressed CRMP2 augments malignant traits of colorectal cancer and is associated with advanced tumor stage. Regulation of CRMP2 profile was further explored in this study using 3T3-L1 pre-adipocyte adipogenesis as a study model for illustrating the roles of CRMP2 in metabolic homeostasis. Hyperglycemia inhibited expression of CRMP2, adipogenic machinery and adipocyte markers. CRMP2 displayed f-CRMP2 (62~66 kDa) and s-CMRP2 (58 kDa) isoforms at the growth arrest phase. Expression of s-CRMP2 was coupled with the mitotic clonal expansion (MCE) phase to direct cell proliferation and rapidly down-regulated in post-mitotic cells. In the late differentiation phase, f-CRMP2 was co-localized with tubulin in the cortical area. Insulin-enhanced CRMP2-glucose transporter 4 (GLUT4) co-localization and CRMP2 puncta on lipid droplets (LDs) suggested participation of CRMP2 in GLUT4 translocation and LD fusion. Collectively, the CRMP2 functional profile must be finely controlled to adjust cytoskeletal stability for meeting dynamic cellular needs. Manipulating the s-CRMP2/f-CRMP2 ratio and thus the cytoskeleton dynamics is anticipated to improve glucose uptake and insulin sensitivity. In summary, our data provide molecular evidence explaining the functions of CRMP2 in physiological, pathological and disease progression in metabolic homeostasis and disorders related to metabolic abnormalities, including cancer. Full article
(This article belongs to the Special Issue Advances in Adipogenesis and Adipose Tissue Metabolism)
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19 pages, 2847 KiB  
Article
Production of Reactive Oxygen Species by Epicardial Adipocytes Is Associated with an Increase in Postprandial Glycemia, Postprandial Insulin, and a Decrease in Serum Adiponectin in Patients with Severe Coronary Atherosclerosis
by Natalia V. Naryzhnaya, Olga A. Koshelskaya, Irina V. Kologrivova, Tatiana E. Suslova, Olga A. Kharitonova, Sergey L. Andreev, Alexander S. Gorbunov, Boris K. Kurbatov and Alla A. Boshchenko
Biomedicines 2022, 10(8), 2054; https://doi.org/10.3390/biomedicines10082054 - 22 Aug 2022
Cited by 10 | Viewed by 2218
Abstract
Purpose. This work investigates the relations between the production of reactive oxygen species (ROS) by epicardial adipose tissue (EAT) adipocytes and parameters of glucose/insulin metabolism, circulating adipokines levels, and severity of coronary atherosclerosis in patients with coronary artery disease (CAD); establishing significant determinants [...] Read more.
Purpose. This work investigates the relations between the production of reactive oxygen species (ROS) by epicardial adipose tissue (EAT) adipocytes and parameters of glucose/insulin metabolism, circulating adipokines levels, and severity of coronary atherosclerosis in patients with coronary artery disease (CAD); establishing significant determinants describing changes in ROS EAT in this category of patients. Material and methods. This study included 19 patients (14 men and 5 women, 53–72 y.o., 6 patients with diabetes mellitus type 2; 5 patients with prediabetes), with CAD, who underwent coronary artery bypass graft surgery. EAT adipocytes were isolated by the enzymatic method from intraoperative explants obtained during coronary artery bypass grafting. The size of EAT adipocytes and ROS level were determined. Results. The production of ROS by EAT adipocytes demonstrated a direct correlation with the level of postprandial glycemia (rs = 0.62, p < 0.05), and an inverse correlation with serum adiponectin (rs = −0.50, p = 0.026), but not with general and abdominal obesity, EAT thickness, and dyslipidemia. Regression analysis demonstrated that the increase in ROS of EAT adipocytes occurs due to the interaction of the following factors: postprandial glycemia (β = 0.95), postprandial insulin (β = 0.24), and reduced serum adiponectin (β = −0.20). EAT adipocytes in patients with diabetes and prediabetes manifested higher ROS production than in patients with normoglycemia. Although there was no correlation between the production of ROS by EAT adipocytes and Gensini score in the total group of patients, higher rates of oxidative stress were observed in EAT adipocytes from patients with a Gensini score greater than median Gensini score values (≥70.55 points, Gr.B), compared to patients with less severe coronary atherosclerosis (<70.55 points, Gr.A). Of note, the frequency of patients with diabetes and prediabetes was higher among the patients with the most severe coronary atherosclerosis (Gr.B) than in the Gr.A. Conclusions. Our data have demonstrated for the first time that systemic impairments of glucose/insulin metabolism and a decrease in serum adiponectin are significant independent determinants of oxidative stress intensity in EAT adipocytes in patients with severe coronary atherosclerosis. The possible input of the interplay between oxidative stress in EAT adipocytes and metabolic disturbances to the severity of coronary atherosclerosis requires further investigation. Full article
(This article belongs to the Special Issue Advances in Adipogenesis and Adipose Tissue Metabolism)
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13 pages, 1200 KiB  
Article
Evaluation of Adipose Tissue Zinc-Alpha 2-Glycoprotein Gene Expression and Its Relationship with Metabolic Status and Bariatric Surgery Outcomes in Patients with Class III Obesity
by José Ignacio Martínez-Montoro, Luis Ocaña-Wilhelmi, Rocío Soler-Humanes, Hanieh Motahari-Rad, Andrés González-Jiménez, José Rivas-Becerra, Alba Rodríguez-Muñoz, Francisco J. Moreno-Ruiz, Mónica Tomé, Jorge Rodríguez-Capitán, Eduardo García-Fuentes, Francisco J. Tinahones, Lourdes Garrido-Sánchez and Mora Murri
Biomedicines 2022, 10(7), 1502; https://doi.org/10.3390/biomedicines10071502 - 25 Jun 2022
Cited by 2 | Viewed by 2326
Abstract
Zinc-α2 glycoprotein (ZAG) is an adipokine involved in adipocyte metabolism with potential implications in the pathogenesis of metabolic disorders. Our aim was to evaluate the relationship between visceral (VAT) and subcutaneous adipose tissue (SAT) ZAG expression and metabolic parameters in patients with class [...] Read more.
Zinc-α2 glycoprotein (ZAG) is an adipokine involved in adipocyte metabolism with potential implications in the pathogenesis of metabolic disorders. Our aim was to evaluate the relationship between visceral (VAT) and subcutaneous adipose tissue (SAT) ZAG expression and metabolic parameters in patients with class III obesity, along with the impact of basal ZAG expression on short- and medium-term outcomes related to bariatric surgery. 41 patients with class III obesity who underwent bariatric surgery were included in this study. ZAG gene expression was quantified in SAT and VAT. Patients were classified into two groups according to SAT and VAT ZAG percentile. Anthropometric and biochemical variables were obtained before and 15 days, 45 days, and 1 year after surgery. The lower basal SAT ZAG expression percentile was associated with higher weight and waist circumference, while the lower basal VAT ZAG expression percentile was associated with higher weight, waist circumference, insulin, insulin resistance, and the presence of metabolic syndrome. Basal SAT ZAG expression was inversely related to weight loss at 45 days after surgery, whereas no associations were found between basal VAT ZAG expression and weight loss after surgery. Additionally, a negative association was observed between basal SAT and VAT ZAG expression and the decrease of gamma-glutamyl transferase after bariatric surgery. Therefore, lower SAT and VAT ZAG expression levels were associated with an adverse metabolic profile. However, this fact did not seem to confer worse bariatric surgery-related outcomes. Further research is needed to assess the clinical significance of the role of ZAG expression levels in the dynamics of hepatic enzymes after bariatric surgery. Full article
(This article belongs to the Special Issue Advances in Adipogenesis and Adipose Tissue Metabolism)
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