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Biomedicines
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Hydrogen Sulfide: Physiology and Pharmacology
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Hydrogen Sulfide: Physiology and Pharmacology

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: closed (15 December 2022) | Viewed by 5503

Special Issue Editor

Dr. Valentina Citi

E-Mail Website
Guest Editor
Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy
Interests: hydrogen sulfide; cardiovascular; hypertension; isothiocyanates; endothelium; vascular inflammation; diabetes; retinopathy

Special Issue Information

Dear Colleagues,

Hydrogen sulfide (H2S) is an important gaseous signaling molecule which plays a fundamental role in several physiological processes. An impaired production of endogenous H2S is often related to the pathogenesis of many pathological conditions, bringing up the necessity to develop and investigate innovative molecules able to donate H2S in an endogenous-like manner. This special issue aims at describing the most recent advances in hydrogen sulfide donors which could represent potential therapeutic pharmacological strategies in the management of those pathological conditions in which H2S synthesis is impaired.

Dr. Valentina Citi
Guest Editor

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Hydrogen sulfide
  • Hydrogen sulfide donors
  • gaseous molecules
  • therapeutic application of H2S donors

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Published Papers (2 papers)

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Research

13 pages, 10113 KiB  
Article
Hydrogen Sulfide Inhibited Sympathetic Activation in D-Galactose-Induced Aging Rats by Upregulating Klotho and Inhibiting Inflammation in the Paraventricular Nucleus
by Hao Yu, Qiyao Yu, Yuan Mi, Ping Wang, Sheng Jin, Lin Xiao, Qi Guo and Yuming Wu
Biomedicines 2023, 11(2), 566; https://doi.org/10.3390/biomedicines11020566 - 15 Feb 2023
Cited by 4 | Viewed by 1988
Abstract
The present study aimed to explore the central relationship between cardiovascular conditions and aging. D-galactose (D-gal) was utilized to induce an accelerated aging model and to evaluate the effects of hydrogen sulfide (H2S) on aging-related cardiovascular risk factors and mechanisms. Eight-week-old [...] Read more.
The present study aimed to explore the central relationship between cardiovascular conditions and aging. D-galactose (D-gal) was utilized to induce an accelerated aging model and to evaluate the effects of hydrogen sulfide (H2S) on aging-related cardiovascular risk factors and mechanisms. Eight-week-old Sprague Dawley rats were given an intraperitoneal injection of 250 mg/kg D-gal every day with or without H2S (56 μmol/kg) for 12 weeks. We found that D-gal treatment induced a noticeably aging-related increase in p16, p53 and p21 protein levels and senescence-associated beta-galactosidase staining. In addition, the level of noradrenalin was increased, accompanied by enhanced blood pressure and renal sympathetic nerve activity in aged rats. The greater sympathetic responses were related with the increased level of inflammation. The decreased level of klotho in the paraventricular nucleus neuron also contributed to sympathetic activation in D-gal-induced aged rats. However, the exogenous administration of H2S attenuated the sympathetic activity in aged rats, as evidenced by the decreased blood pressure, renal sympathetic nerve activity and noradrenalin level. The ameliorated cellular senescence, inflammation and heightened klotho in the paraventricular nucleus were attributed to the protective effects of H2S. The present study provides further evidence for the drug development of H2S for the prevention or treatment of the aging-associated cardiovascular diseases. Full article
(This article belongs to the Special Issue Hydrogen Sulfide: Physiology and Pharmacology)
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21 pages, 4530 KiB  
Article
The Effects of H2S and Recombinant Human Hsp70 on Inflammation Induced by SARS and Other Agents In Vitro and In Vivo
by Sergei Onikienko, Maxim Vinokurov, Marina Yurinskaya, Alexander Zemlyanoi, Sergei Abkin, Elvira Shaykhutdinova, Victor Palikov, Alexander Ivanov, Olga Smirnova, Irina Fedyakina, Natalia Bychkova, Olga Zatsepina, David Garbuz and Michael Evgen’ev
Biomedicines 2022, 10(9), 2155; https://doi.org/10.3390/biomedicines10092155 - 1 Sep 2022
Cited by 4 | Viewed by 2454
Abstract
The ongoing epidemic caused by SARS-CoV-2 infection led to the search for fundamentally new ways and means to combat inflammation and other pathologies caused by this virus. Using a cellular model of lipopolysaccharide (LPS)-induced sepsis (human promonocytes), we showed that both a hydrogen [...] Read more.
The ongoing epidemic caused by SARS-CoV-2 infection led to the search for fundamentally new ways and means to combat inflammation and other pathologies caused by this virus. Using a cellular model of lipopolysaccharide (LPS)-induced sepsis (human promonocytes), we showed that both a hydrogen sulfide donor (sodium thiosulfate, STS) and a recombinant Heat shock protein 70 (rHsp70) effectively block all major inflammatory mediators when administrated before and after LPS challenge. The protective anti-inflammatory effect of rHsp70 and H2S was also confirmed in vivo using various animal models of pneumonia. Specifically, it was found that rHsp70 injections prevented the development of the acute respiratory distress syndrome in highly pathogenic pneumonia in mice, increased animal survival, and reduced the number of Programmed death-1 (PD-1)-positive T-lymphocytes in peripheral blood. Based on our model experiments we developed a combined two-phase therapeutic approach for the treatment of COVID-19 patients. This procedure includes the inhalation of hot helium–oxygen mixtures for induction of endogenous Hsp70 in the first phase and STS inhalation in the second phase. The use of this approach has yielded positive results in COVID-19 patients, reducing the area of lung lesions, restoring parameters of innate immunity and T-cell immune response against coronavirus infection, and preventing the development of pulmonary fibrosis and immune exhaustion syndrome. Full article
(This article belongs to the Special Issue Hydrogen Sulfide: Physiology and Pharmacology)
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