Regulatory Role of ECM Biophysical Signals on Cell and Nuclear Mechanics
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".
Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 3949
Special Issue Editors
Interests: Cell and ECM mechanics; mechanobiology; biomaterials; tissue engineering
Interests: Mechanosensing; Mechanotransduction; Focal Adhesions; Matrix Mechanics; Lab-on-chip devices; Biomaterials; Tissue Engineering; Nanomedicine
Special Issue Information
Dear Colleagues,
In vivo, cells are continuously exposed to multiple microenvironmental stimuli, such as chemical, topographic, and mechanical gradients encased within the extracellular matrix, which control their time and space presentation to tightly regulate cell and tissue functions. Recently, it has been appreciated that extracellular-borne forces are transmitted to the nucleus via the cytoskeletal filaments and biochemical signaling to alter the chromatin organization, inter-chromosome contacts, and gene expression programs. This foundation of mechanobiology aims to link the regulatory role of biophysical signals on cell functions (i.e., migration, differentiation, and neoplastic transformation) with the tensional status of the cytoskeleton along with the mechanical interplay between cytoskeletal forces and nuclear envelope deformation.
Focusing on these key aspects, we believe that this Special Issue offers the opportunity to develop a deeper understanding of the mechanisms that regulate mechanically induced alterations in chromatin organization and their effects on cell state and fate by assessing cell cytoskeleton mechanics in a proper extracellular context. In this Special Issue, we provide researchers working in different but congruent areas of research—such as bioengineering, biomedical engineering, biophysics, material science, and tissue engineering—the opportunity to address these fundamental mechanisms by disclosing the existing relationships between the biophysical properties of cell microenvironments and cell mechanical properties.
Dr. Valeria Panzetta
Dr. Sabato Fusco
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
