Applications of NMR Spectroscopy in Structure-Based Drug Discovery
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Structure and Dynamics".
Deadline for manuscript submissions: 31 December 2024 | Viewed by 275
Special Issue Editors
Interests: structural biology; NMR; biophysics; drug discovery; protein dynamics; fragments; fibroblast growth factor receptors
Interests: fragment-based drug discovery; NMR and biophysics in general; allostery; protein dynamics; laboratory automation
Special Issue Information
Dear Colleagues,
NMR is a supremely versatile experimental technique whose unique strengths have been widely exploited to enable the discovery, characterization and optimization of bioactive molecules with the potential to become new drugs. In this Special Issue, we chart the evolution and application of NMR spectroscopy to structure-based drug discovery, both within industry and in academic labs. From its origins as a largely analytical technique for small-molecule characterization, through the ‘boom years’ of the 1990s and X-ray vs. NMR ‘structure wars’, the emergence of NMR-driven fragment-based drug discovery, and the maturation of NMR as a ‘gold-standard’ method for verification, characterization and annotation of lead–target interactions, NMR has continued to adapt and evolve as the demands and priorities of modern drug discovery have shifted.
Prof. Dr. Alexander L. Breeze
Dr. Reto Walser
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Dr. Reto Walser
Prof. Dr. Alexander L. Breeze
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- NMR
- structural biology
- structure-based drug discovery
- fragment screening
- lead generation
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