Ion Channels in Cardiovascular and Metabolic Diseases
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Biological Factors".
Deadline for manuscript submissions: 31 May 2025 | Viewed by 145
Special Issue Editor
Interests: cardiovascular disease; diabetic complications; obesity; ion channels; oxidative stress; Ca2+ signalling; drug discovery
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Ion channels are pore-forming proteins that exist across the plasma membrane or membranes of intracellular organelles. They are critical biomolecules that regulate cell physiology or act as drug targets. Many cellular functions are regulated by ion channels, such as the control of membrane potential, membrane excitation, muscle contraction/relaxation, hormone secretion, and signal transmission. Ion channels also regulate cell proliferation, differentiation and apoptosis by affecting the transcription of related genes. The dysfunction (gain of function or loss of function) of ion channels due to mutations or abnormal gene expression can cause various diseases.
There are many ion channel families, including the well studied voltage-gated Na+, Ca2+, K+, and Cl− channels, and relatively new ion channels such as the TRP superfamily, which can be activated by G-protein coupled receptor activation or second messengers or other intracellular and/or extracellular mediators. The mechanosensitive channels, Piezo channels, ORAI channels, water channels (aquaporins) and connexins are also important in the regulation of cardiovascular function and metabolic processes.
We are pleased to invite you to submit to this Special Issue entitled “Ion Channels in Cardiovascular and Metabolic Diseases”. This Special Issue aims to collect papers that present studies on ion channels and their implications for cardiovascular diseases, diabetes and other metablic diseases. This is in provide an overview of recent advances regarding various ion channel molecules in all aspects of biomedical research. We encourage the submission of papers that cover molecular biology, biochemistry, biophysics, genetics, pathophysiology and pharmacology to address diverse ion channels and their significance in disease pathogenesis, channelopathies and potential therapeutics.
In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not be limited to) the following: all types of cation and anion channels, membrane transporters and their closely related partner proteins or regulators.
We look forward to receiving your contributions.
Dr. Shang-Zhong Xu
Guest Editor
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
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Keywords
- Na+ channel
- Ca2+ channel
- K+ channel
- TRP channel
- store-operated channel
- Cl− channel
- cation channel
- ryanodine receptor
- mechanosenstive channels
- piezo channels
- SGLT-1 transporters
- membrane transporters
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