Advances in Molecular Therapy Targeting DNA Damage and Repair Systems
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Biological Factors".
Deadline for manuscript submissions: 31 May 2025 | Viewed by 86
Special Issue Editors
Interests: neurodegeneration; DNA repair; cardiovascular; neurodevelopment; neuro-inflammation
Interests: DNA repair; neuroscience; fusobacterium-mediated inflammation
Special Issue Information
Dear Colleagues,
DNA damage and repair defects have been emerging as a central player in a broad spectrum of human diseases, such as neurodegeneration, cardiovascular diseases, and cancer. DNA base mutations, abnormal sequence deletion/inclusion, nucleotide adduct formation, and chromatin landscape alterations are the major pathological changes in DNA molecules that can lead to sporadic or familial diseases. In most cases, uncontrolled inflammatory responses due to persistent DNA damage response (DDR) signal activation and impaired or defective repair machinery are believed to be the main etiopathological factors.
In this Special Issue, we invite original studies and review articles covering the molecular advances in DNA damage and repair systems, such as what is the relationship between DNA damage and metabolic dysfunctions and how chromatin structure remodeling influences repair processes. These advances will enable researchers to better understand the mechanisms of DDR and DNA repair. That will also lead to new therapeutic strategies for treating DNA damage-related diseases, including cancer and neurodegeneration.
Dr. Joy Mitra
Dr. Anirban Chakraborty
Dr. Anahita Mojiri
Guest Editors
Manuscript Submission Information
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Keywords
- DNA repair
- DNA repair inhibitors
- homologous recombination
- genome instability
- inflammation
- DNA damage
- cell death
- apoptosis
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