Bone Sarcomas: From Molecular Mechanisms to Therapies Strategies
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: closed (31 March 2022) | Viewed by 460
Special Issue Editors
Interests: bone and soft tissue sarcomas; rare tumors; melanoma
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Primary bone sarcomas are extremely rare tumors accounting for less than 0.2% of all cancers. In adults, over 40% of primary bone cancers are chondrosarcomas. This is followed by osteosarcomas (28%), chordomas (10%), Ewing tumors (8%), and malignant fibrous histiocytoma/fibrosarcomas (4%). The remainder of cases are several even more rare types of bone cancers. Both osteosarcoma and Ewing sarcoma occur most often in children and teens (younger than 20 years) where they represent 56% and 34%, respectively, of the diagnosis of bone sarcomas.
Primary bone sarcomas demonstrate wide clinical heterogeneity. High-grade bone sarcomas require intensive treatment due to their rapid and invasive growth pattern, and although intensive chemotherapy and establishment of surgical procedures have improved the outcomes of patients with sarcoma, the curative rate of recurrent and metastatic sarcomas is still not satisfactory. Because of this rarity and heterogeneity, the development of adequately powered clinical trials has been moreover a challenge. Consequently, the treatment landscape has evolved little in the last decade and novel therapies are urgently needed, particularly in the metastatic setting.
The aim of this special issue is to highlight the advances in the treatment for bone sarcomas with particular attention to the elucidation of new biological pathways and molecular alterations as potential therapeutic targets.
Dr. Virginia Ferraresi
Prof. Dr. Sabrina Vari
Guest Editors
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Keywords
- Osteosarcoma
- Ewing Sarcoma
- Condrosarcoma
- Cordoma
- “Histotype bone STM”
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