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Brain Sciences
Special Issues
Minimally Invasive Surgery for Brain and Skull Base Tumors
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Minimally Invasive Surgery for Brain and Skull Base Tumors

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neurosurgery and Neuroanatomy".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 1055

Special Issue Editor

Dr. Carmine Antonio Donofrio

E-Mail Website
Guest Editor
Department of Neurosurgery, ASST Cremona, 26100 Cremona, Italy
Interests: brain tumors; pituitary tumors; neuroanatomy; microneurosurgery; adjuvant in neurosurgery; liquid biopsy; minimally invasive neurosurgery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Background and history of this topic:

Minimally invasive surgery for brain and skull base tumors aims to minimize the extent of exposure and manipulation of unaffected tissues, to reduce surgical morbidities and improve postoperative recovery. Keyhole, endoscopic, stereotactic, and parafascicular approaches require dedicated surgical instrumentation and adjuvants, such as neuronavigational systems, intraoperative ultrasounds, endoscopes, or tubular retractors. Tailoring approaches to specific areas of interest, manipulating surgical targets, and managing potential complications through narrow surgical corridors may be technically demanding and can be mastered after long-lasting operative learning curves.

Aim and scope of the Special Issue:

This Special Issue aims to explore the current and future applications of minimally invasive surgery for the resection of brain and skull base tumors.

Cutting-edge research:

The cutting-edge research in this field includes surgical anatomy studies, technical notes, and clinical series.

What kind of papers we are soliciting:

We welcome original articles and reviews focused on innovative diagnostic and surgical approaches that provide novel strategies in the challenging management of these tumors.

Dr. Carmine Antonio Donofrio
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • minimally invasive surgery
  • keyhole approaches
  • endoscopic surgery
  • stereotactic surgery
  • parafascicular surgery
  • brain tumors
  • neuro-oncology
  • skull base tumors

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Published Papers (1 paper)

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Review

12 pages, 503 KiB  
Review
Pediatric Fibrous Dysplasia of the Skull Base: Update on Management and Treatment
by Pierce Spencer, Vidhatri Raturi, Amanda Watters and R. Shane Tubbs
Brain Sci. 2024, 14(12), 1210; https://doi.org/10.3390/brainsci14121210 - 29 Nov 2024
Viewed by 767
Abstract
Background: Fibrous dysplasia (FD) is often difficult for skull base surgeons to address. FD arises due to the abnormal proliferation of fibroblasts, ultimately resulting in immature osseous tissue replacing normal cancellous bone. When the skull base is involved, it can result in cranial [...] Read more.
Background: Fibrous dysplasia (FD) is often difficult for skull base surgeons to address. FD arises due to the abnormal proliferation of fibroblasts, ultimately resulting in immature osseous tissue replacing normal cancellous bone. When the skull base is involved, it can result in cranial nerve compression. FD affecting the optic canal and optic nerve is the most concerning as new onset of vision loss is considered a surgical emergency. The prevalence of FD is approximately 3.6 per 1,000,000. The most severe implications of this disease are neurological deficits due to cranial nerve compression, cosmetic appearance, and high recurrence rates even in the setting of surgical and medical therapy interventions. Methods: A PubMed search of “pediatric fibrous dysplasia management” using MESH Terms was conducted. Articles were excluded for non-English languages, inaccessibility, and events/erratum/letters to the editor. Included articles were in English, as well as encompassed pediatric FD case reports or comprehensive reviews of FD that discussed pediatric presentations. Results: A total of 109 articles were reviewed, and 44 were included in the final review. Most articles were case reports. There is a clear need for guidelines regarding surgical intervention, especially in the pediatric population, where hormonal fluctuation can influence rates of recurrence and bony deformity. Overall, most surgeons recommend close observation with biomarkers and radiographic imaging for asymptomatic patients until at least the age of 16 years old. Conservative methods, such as RANK-L inhibitors, can be utilized to decrease growth with some success, especially in older adolescents. Conclusion: This review is an update on this disease and its presentations, imaging findings, and treatment options. The current literature lacks clear guidance on management, especially in regard to surgical intervention or recurrence monitoring algorithms. Full article
(This article belongs to the Special Issue Minimally Invasive Surgery for Brain and Skull Base Tumors)
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