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Brain Sciences
Special Issues
Molecular and Cellular Biology of Brain Tumors and Neuro-Oncology
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Molecular and Cellular Biology of Brain Tumors and Neuro-Oncology

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neuro-oncology".

Deadline for manuscript submissions: 16 May 2025 | Viewed by 1321

Special Issue Editor

Dr. Rafael Roesler

E-Mail Website
Guest Editor
1. Cancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), Federal University of Rio Grande do Sul, Porto Alegre 90035-003, Brazil
2. Department of Pharmacology, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90035-003, Brazil
Interests: brain tumor; glioma; glioblastoma; neuroblastoma; medulloblastoma; growth factors; membrane receptors; epigenetics

Special Issue Information

Dear Colleagues,

Understanding the cellular and molecular processes underlying the origin and progression of brain tumors, as well as the mechanisms of resistance to treatment and metastasis, is crucial for the development of better diagnostic tools and molecularly targeted innovative therapies. Despite important advances made in brain tumor biology over recent years, prognosis remains dismal, and survivors suffer from long-term sequelae of cytotoxic chemotherapy, radiotherapy, and surgical interventions. In this Special Issue of Brain Sciences, the current state of knowledge on the biological basis of brain tumor types including gliomas, medulloblastoma, and ependymomas will be addressed, and the potential applications of this knowledge for the development of novel diagnostic and therapeutic strategies will be presented.

Dr. Rafael Roesler
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • glioma
  • medulloblastoma
  • ependymoma
  • brain cancer
  • central nervous system tumor
  • neuro-oncology

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Published Papers (1 paper)

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Research

8 pages, 1762 KiB  
Communication
High Expression of GABAA Receptor β Subunit Genes Is Associated with Longer Overall Survival in Medulloblastoma
by Jander M. Monteiro, Matheus Dalmolin, Marcelo A. C. Fernandes, Jaqueline I. R. Ramos, Carmen A. P. M. Ribas, Fernando I. Tabushi, Rafael Roesler and Gustavo R. Isolan
Brain Sci. 2024, 14(11), 1146; https://doi.org/10.3390/brainsci14111146 - 15 Nov 2024
Viewed by 949
Abstract
Background/Objectives: Most of the rapid inhibitory neurotransmission in the brain is mediated through activation of the γ-aminobutyric acid (GABA) type A (GABAA) receptor, which is a ligand-gated ion channel. GABAA receptor activation via GABA binding allows for an intracellular influx [...] Read more.
Background/Objectives: Most of the rapid inhibitory neurotransmission in the brain is mediated through activation of the γ-aminobutyric acid (GABA) type A (GABAA) receptor, which is a ligand-gated ion channel. GABAA receptor activation via GABA binding allows for an intracellular influx of Cl− ions, thus inducing cellular hyperpolarization. Each GABAA receptor consists of a combination of five subunits, and several subunits have been proposed as biomarkers and therapeutic targets in cancer. Here, we show the expression of genes encoding β subunits of the GABAA receptor, namely GABRB1, GABRB2, and GABRB3, across the four different molecular subgroups of medulloblastoma (MB), which is the most common malignant pediatric brain tumor. We also show the associations of GABAA receptor β subunits with MB patients’ overall survival (OS). Methods: The expression of genes encoding GABAA receptor β subunits was analyzed using a previously described dataset comprising 763 MB tumor samples. Patients were classified into high- and low-gene-expression groups, and the Kaplan–Meier estimate was used to examine the relationship between gene expression levels and patient OS. Results: High GABRB1 expression was associated with better OS within each of the four molecular subgroups. The GABRB2 gene showed higher transcript levels in Group 3 MB compared to all other subgroups, and high expression was associated with better prognosis in Group 3 tumors. GABRB3 expression was significantly higher in Group 3 and Group 4 MB, and high expression of GABRB3 genes was associated with longer OS in the sonic hedgehog (SHH) subgroup. The high expression of GABRB1, GABRB2, and GABRB3 is associated with longer patient OS in a subgroup-specific manner. Conclusions: These results indicate a role for GABAA receptors containing β subunits in influencing MB progression. Full article
(This article belongs to the Special Issue Molecular and Cellular Biology of Brain Tumors and Neuro-Oncology)
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