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Brain Sciences
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Primary Progressive Aphasia and Apraxia of Speech
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Primary Progressive Aphasia and Apraxia of Speech

A topical collection in Brain Sciences (ISSN 2076-3425). This collection belongs to the section "Neurolinguistics".

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Editors

Dr. Jordi A. Matias-Guiu

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Collection Editor
Department of Neurology, Institute of Neurosciences, Hospital Clinico San Carlos, San Carlos Institute for Health Research (IdISSC), Universidad Complutense de Madrid, 28223 Madrid, Spain
Interests: Alzheimer disease; neurodegenerative diseases; cognition; cognitive post-COVID-19 disease; neuroimaging
Special Issues, Collections and Topics in MDPI journals
Dr. Robert Jr Laforce

E-Mail Website
Collection Editor
Clinique Interdisciplinaire de Mémoire (CIME) du CHU de Québec, Département des Sciences Neurologiques, Québec, QC G3N 0A4 , Canada
Interests: atypical dementia; frontotemporal dementia; primary progressive aphasia; molecular neuroimaging; biomarkers; cognitive screening tests
Special Issues, Collections and Topics in MDPI journals
Dr. Rene L. Utianski

E-Mail Website
Collection Editor
Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
Interests: frontotemporal dementia; aphasia; apraxia of speech; neuroimaging; electroencephalography
Special Issues, Collections and Topics in MDPI journals

Topical Collection Information

Dear Colleagues,

Primary progressive aphasia (PPA) is a group of neurodegenerative disorders, characterized by progressive language impairment, as well as cognitive and behavioral changes. By contrast, primary progressive apraxia of speech (PPAOS) is characterized by progressive speech impairment. Our knowledge regarding these disorders has evolved significantly in recent years. Notably, correlations between clinical findings and pathology have improved, and the main clinical, neuroimaging, and genetic features have been described. Furthermore, primary progressive aphasia and apraxia of speech are good models for the study of brain–behavior relationships and have contributed to the knowledge of the neural basis of language and speech functioning. However, many open questions remain. For instance, the classification of PPA into three variants (non-fluent, semantic, and logopenic) is under debate; further data about the epidemiology and natural history of diseases are needed; and, as in other neurodegenerative disorders, successful therapies are lacking.

For this Topic, we invite scholars to submit original research studies and reviews regarding all possible aspects of primary progressive aphasia and apraxia of speech, including basic science, epidemiology, clinical findings, longitudinal course, language and speech features, validation of neuropsychological tools for diagnosis, neuroimaging, blood and cerebrospinal fluid biomarkers, pathology, and treatments. A special focus should be on topics that can advance our assessment, differential diagnosis, and treatment of PPAs and PPAOS.

Dr. Jordi A. Matias-Guiu
Dr. Robert Jr Laforce
Dr. Rene L. Utianski
Collection Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the collection website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (3 papers)

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2024

Jump to: 2023, 2022

19 pages, 2208 KiB  
Case Report
Efficacy of LSVT LOUD® on Phonatory Control and Voice Quality in Patients with Primary Progressive Apraxia of Speech: Case Studies
by Yee Nam Candice Choi, Vincent Martel-Sauvageau, Myriam Breton, Monica Lavoie, Robert Laforce, Jr. and Liziane Bouvier
Brain Sci. 2024, 14(5), 417; https://doi.org/10.3390/brainsci14050417 - 24 Apr 2024
Viewed by 2408
Abstract
Primary progressive apraxia of speech (PPAOS) is a neurodegenerative syndrome characterized by the progressive and initially isolated or predominant onset of difficulties in the planning/programming of movements necessary for speech production and can be accompanied by dysarthria. To date, no study has used [...] Read more.
Primary progressive apraxia of speech (PPAOS) is a neurodegenerative syndrome characterized by the progressive and initially isolated or predominant onset of difficulties in the planning/programming of movements necessary for speech production and can be accompanied by dysarthria. To date, no study has used an evidence-based treatment to address phonation control in patients with PPAOS. The aim of this study was to evaluate the feasibility and efficacy of LSVT LOUD® as a treatment for phonatory control in speakers with PPAOS. Three speakers with PPAOS received LSVT LOUD® therapy, and changes in phonatory control, voice quality and prosody were measured immediately, and one, four and eight weeks after the end of the treatment. Overall, the results suggest that the treatment is feasible and could improve voice quality, intensity, and control in some patients with PPAOS. The generalization of the results is also discussed. Full article
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2023

Jump to: 2024, 2022

15 pages, 720 KiB  
Article
Executive Profile of the Logopenic Variant of Primary Progressive Aphasia: Comparison with the Semantic and Non-Fluent Variants and Alzheimer’s Disease
by Sandrine Basaglia-Pappas, Bernard Laurent, Jean-Claude Getenet, Anne Boulangé, Aurelia Rendón de laCruz, Isabelle Simoes Loureiro and Laurent Lefebvre
Brain Sci. 2023, 13(3), 406; https://doi.org/10.3390/brainsci13030406 - 26 Feb 2023
Cited by 4 | Viewed by 3533
Abstract
The logopenic variant of primary progressive aphasia (lvPPA) shows different features from the non-fluent (nfvPPA) and semantic (svPPA) variants of PPA. Although language impairments remain the core symptoms, studies have highlighted the presence of executive disorders at the onset of the disease. Nevertheless, [...] Read more.
The logopenic variant of primary progressive aphasia (lvPPA) shows different features from the non-fluent (nfvPPA) and semantic (svPPA) variants of PPA. Although language impairments remain the core symptoms, studies have highlighted the presence of executive disorders at the onset of the disease. Nevertheless, the results are contradictory, particularly in lvPPA. The aim of this study was to explore the executive profile of lvPPA. We compared executive functioning in lvPPA with the other two variants of PPA, Alzheimer’s disease (AD) and a cognitively healthy group. In total, 70 patients with PPA, 32 patients with AD, and 41 healthy controls were included. They underwent a comprehensive executive battery assessing short-term and working memory, inhibition, flexibility, planning, and initiation. The analyses showed significant differences between the lvPPA group and the control group, except on visuospatial spans and the Stroop test, and between the lvPPA group and the other PPA groups and the AD group for several tasks. Thus, this research highlighted the existence of an executive dysfunction from the onset of the disease in lvPPA but also in the other two variants of PPA. Full article
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Graphical abstract

2022

Jump to: 2024, 2023

18 pages, 367 KiB  
Article
The Discourse Profile in Corticobasal Syndrome: A Comprehensive Clinical and Biomarker Approach
by Isabel Junqueira de Almeida, Marcela Lima Silagi, Maria Teresa Carthery-Goulart, Jacy Bezerra Parmera, Mario Amore Cecchini, Artur Martins Coutinho, Sonia Maria Dozzi Brucki, Ricardo Nitrini and Eliane Schochat
Brain Sci. 2022, 12(12), 1705; https://doi.org/10.3390/brainsci12121705 - 12 Dec 2022
Cited by 2 | Viewed by 2290
Abstract
The aim of this study was to characterize the oral discourse of CBS patients and to verify whether measures obtained during a semi-spontaneous speech production could differentiate CBS patients from controls. A second goal was to compare the performance of patients with CBS [...] Read more.
The aim of this study was to characterize the oral discourse of CBS patients and to verify whether measures obtained during a semi-spontaneous speech production could differentiate CBS patients from controls. A second goal was to compare the performance of patients with CBS probably due to Alzheimer’s disease (CBS-AD) pathology and CBS not related to AD (CBS-non-AD) in the same measures, based on the brain metabolic status (FDG-PET) and in the presence of amyloid deposition (amyloid-PET). Results showed that CBS patients were significantly different from controls in speech rate, lexical level, informativeness, and syntactic complexity. Discursive measures did not differentiate CBS-AD from CBS-non-AD. However, CBS-AD displayed more lexical-semantic impairments than controls, a profile that is frequently reported in patients with clinical AD and the logopenic variant of primary progressive aphasia (lvPPA). CBS-non-AD presented mainly with impairments related to motor speech disorders and syntactic complexity, as seen in the non-fluent variant of PPA. Full article
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