Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
4.8
2.7
Journals
Brain Sciences
Special Issues
Translational EEG Biomarkers in Animal Models: Bridging Pre-Clinical Findings to...
share announcement

Translational EEG Biomarkers in Animal Models: Bridging Pre-Clinical Findings to Human Neuroscience

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neurotechnology and Neuroimaging".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 633

Special Issue Editors

Prof. Dr. Inga Griskova-Bulanova

E-Mail Website
Guest Editor
Department of Neurobiology and Biophysics, Vilnius University, LT-10257 Vilnius, Lithuania
Interests: EEG; biomarkers; neuropsychiatric disorders
Special Issues, Collections and Topics in MDPI journals
Dr. Cestmir Vejmola

E-Mail Website
Guest Editor Assistant
National Institute of Mental Health, Topolová 748, 25067 Klecany, Czech Republic
Interests: neurochemical compounds; EEG; biomarkers

Special Issue Information

Dear Colleagues,

Electroencephalography (EEG) in animal models has been an essential tool for neuroscience, helping to understand brain function in normal and altered conditions. Pre-clinical EEG biomarkers are used to assess the efficacy of potential therapeutic agents, identify the neural circuits and mechanisms involved in specific disorders, and guide research on underlying causes and potential intervention points. Although animal models enable a high degree of control over experimental variables, the data obtained may not always directly translate to human physiology or pathology. Nevertheless, challenges in translating pre-clinical EEG biomarkers exist and are related to species differences, lack of behavioural correlates, and overall complexity of EEG signals.

This upcoming Special Issue of Brain Sciences aims to highlight the current state of the art in translational pre-clinical EEG biomarkers and showcase the latest findings from the study of different conditions, angles, and disciplines including neurophysiology, neurology, pharmacology, neurogenetics, neuro-engineering, and psychiatry. We aim to raise interest in and draw attention to the existing pre-clinical  EEG-based biomarkers and initiate discussions on their applicability.

We invite contributions describing the practical utility of pre-clinical EEG biomarkers, papers focusing on methodological advancements, and reports presenting new datasets. Original research articles and review articles are highly encouraged.

Prof. Dr. Inga Griskova-Bulanova
Guest Editor

Dr. Cestmir Vejmola
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • EEG
  • ECoG
  • biomarker
  • animal model
  • pre-clinical

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (1 paper)

Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

13 pages, 1889 KiB  
Article
Normative Values of Brainstem Auditory-Evoked Responses in Sheep
by Katharina Suntinger, Adrian Dalbert, Lukas Prochazka, Milena Tegelkamp, Peter Kronen, Karina Klein, Christof Röösli, Alexander Huber and Flurin Pfiffner
Brain Sci. 2025, 15(1), 69; https://doi.org/10.3390/brainsci15010069 - 14 Jan 2025
Viewed by 493
Abstract
Background: The brainstem auditory-evoked response (BAER) is an established electrophysiological measure of neural activity from the auditory nerve up to the brain stem. The BAER is used to diagnose abnormalities in auditory pathways and in neurophysiological human and animal research. However, normative data [...] Read more.
Background: The brainstem auditory-evoked response (BAER) is an established electrophysiological measure of neural activity from the auditory nerve up to the brain stem. The BAER is used to diagnose abnormalities in auditory pathways and in neurophysiological human and animal research. However, normative data for BAERs in sheep, which represent an adequate large animal model for translational and basic otological research, are lacking. Objective: The aim of this study was to assess the function of the ovine auditory nervous system by determining normative values for the BAER and to compare sheep with human BAER data. Methods: In this retrospective study, BAER data for click stimuli at a range of sound pressure levels (SPLs) were analyzed. A series of 15 samples from six sheep with a mean age of 41.8 months was included. Results: The mean BAER threshold was 45.3 dB SPL. At 100 dB SPL, the mean (±standard deviation, SD) latency of wave V was 4.35 (±0.18) ms, that of wave III was 2.44 (±0.15) ms, and that of wave I was 0.88 (±0.13) ms. At 100 dB SPL, the mean interpeak latency of waves I–III was 1.56 (±0.18) ms, that of waves III–V was 1.91 (±0.16) ms, and that of waves I–V was 3.47 (±0.20) ms. The mean amplitudes at 100 dB SPL were 0.04 (±0.03) µV for wave I, 0.50 (±0.24) µV for wave III, and 0.40 (±0.25) µV for wave V. Conclusions: The normative values for sheep BAERs were reproducible and similar to those of humans. The normative BAER values further support sheep as an adequate animal model for otological research. Full article
(This article belongs to the Special Issue Translational EEG Biomarkers in Animal Models: Bridging Pre-Clinical Findings to Human Neuroscience)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-1
Back to TopTop