Current Basic and Clinical Approaches in Neurodegenerative Diseases: Diagnostics and Therapeutics

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neurodegenerative Diseases".

Deadline for manuscript submissions: 15 August 2025 | Viewed by 2097

Special Issue Editors


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Guest Editor
1. Department of Philosophical and Methodological Disciplines, University Health Sciences Center, University of Guadalajara, Guadalajara 44340, Jalisco, Mexico
2. Postgraduate Gerontology Program, University Health Sciences Center, University of Guadalajara, Guadalajara 44340, Jalisco, Mexico
Interests: neurodegenerative diseases; basic and clinical approaches
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Guest Editor
Laboratorio de Neurofarmacología, Subdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatría “Ramón de la Fuente Muñiz”, Calzada México Xochimilco No. 101, Col. San Lorenzo Huipulco, Mexico City CP 14370, Mexico
Interests: basic approaches to neuropsychiatric diseases

Special Issue Information

Dear Colleagues,

Neurodegenerative diseases constitute a group of pathologies characterized by the progressive death of neuronal populations in different areas of the brain. The pathological mechanisms underlying these pathologies have not yet been fully clarified, although it has been observed that there are common pathological characteristics. This group of disorders encompasses various pathologies, with symptoms that can vary considerably. The most important neurodegenerative disorders are Alzheimer's disease, Parkinson's disease, Huntington's disease, multiple sclerosis, amyotrophic lateral sclerosis (ALS), etc. It is important to have diagnosis and treatment protocols that not only consider the neurological part since the majority present alterations in other systems. A challenge in this area is the development of new methods and therapies that improve the quality of life of patients.

Objective: analyze current advances, diagnostic and treatment approaches, as well as their protocols, and propose other scientifically based approaches in neurodegenerative diseases.

Basic and clinical research articles; reviews, especially in advances, diagnosis, and treatment.

Dr. Genaro G. Ortiz
Dr. Gloria A. Benítez-King
Guest Editors

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Keywords

  • neurodegenerative diseases
  • advances
  • diagnosis
  • treatment
  • basic clinical approach
  • treatment protocols

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Published Papers (1 paper)

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Review

24 pages, 2889 KiB  
Review
Exosome Cargo in Neurodegenerative Diseases: Leveraging Their Intercellular Communication Capabilities for Biomarker Discovery and Therapeutic Delivery
by Shuai Zhang, Yu Yang, Xinchen Lv, Xue Zhou, Wangqian Zhao, Linfeng Meng, Shaohua Zhu, Zhixiang Zhang and Ying Wang
Brain Sci. 2024, 14(11), 1049; https://doi.org/10.3390/brainsci14111049 - 23 Oct 2024
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Abstract
The inexorable progression of neurodegenerative diseases (NDs), including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, and multiple sclerosis, is closely related to irreversible brain decline. Accurately characterizing pathophysiological features and identifying reliable biomarkers for early diagnosis and optimized treatment are critical. [...] Read more.
The inexorable progression of neurodegenerative diseases (NDs), including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, and multiple sclerosis, is closely related to irreversible brain decline. Accurately characterizing pathophysiological features and identifying reliable biomarkers for early diagnosis and optimized treatment are critical. Hindered by the blood–brain barrier (BBB), obtaining sensitive monitoring indicators for disease progression and achieving efficient drug delivery remain significant challenges. Exosomes, endogenous nanoscale vesicles that carry key bioactive substances, reflect the intracellular environment and play an important role in cell signaling. They have shown promise in traversing the BBB, serving dual roles as potential biomarkers for NDs and vehicles for targeted drug delivery. However, the specific mechanisms by which exosome influence NDs are not fully understood, necessitating further investigation into their attributes and functionalities in the context of NDs. This review explores how exosomes mediate multifaceted interactions, particularly in exacerbating pathogenic processes such as oxidative stress, neuronal dysfunction, and apoptosis integral to NDs. It provides a comprehensive analysis of the profound impact of exosomes under stress and disease states, assessing their prospective utility as biomarkers and drug delivery vectors, offering new perspectives for tackling these challenging diseases. Full article
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