The Progress of Pancreatectomy for Pancreatic Cancer Treatment

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Clinical Research of Cancer".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 1207

Special Issue Editors


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Department of General, Visceral, Thoracic and Transplant Surgery, Ordensklinikum Linz, 4010 Linz, Austria
Interests: surgical oncology; pancreas, liver; bile; upper GI; surgical infection
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Department of Surgery, Ordensklinikum Linz, 4020 Linz, Austria
Interests: surgical oncology; upper GI cancer; esophageal cancer; gastric cancer; clinical trials; minimally invasive surgery; robotic surgery
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Special Issue Information

Dear Colleagues,

Pancreatic cancer represents one of the most challenging areas in gastrointestinal oncology. Surgery plays a key role in pancreatic cancer therapy because surgical resection is a precondition for curative treatment. Major advances have been achieved in pancreatic surgery, with a significant improvement of perioperative outcome parameters due to centralisation in specialised centres. Recurrence-free survival and overall survival have been found to increase following multimodal therapy, with surgery being of decisive influence. However, research defining the role of surgery in multimodal treatment regimens, with special attention paid to resectability and extended resections, as well as the potential significance of minimally invasive resection—whether laparoscopic or robotic—is crucial for pancreatic cancer surgery in the future.

This Special Issue welcomes research in the topics: (a) surgery in the setting of multimodal therapy; (b) timing of surgery according to the status of resectability; (c) minimally invasive resection; (d) outcome research for resectable pancreatic cancer; (e) technique and results of extended pancreatectomy; (f) therapy of postoperative pancreatic fistulas Grad B or C; and (g) pancreatic cancer resection in portal hypertension.

Prof. Dr. Reinhold Függer
Prof. Dr. Matthias Biebl
Guest Editors

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Keywords

  • pancreatic ductal adenocarcinoma (PDAC)
  • pancreatectomy timing in multimodal regimen
  • minimally invasive pancreatectomy for PDAC
  • pancreatectomy and resectability
  • extended pancreatectomy
  • vascular resection and reconstruction
  • outcome research—pancreatectomy for cancer in unselected patient cohorts
  • interaction of postoperative complications and preoperative or adjuvant therapy
  • postoperative pancreatic fistula

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Published Papers (1 paper)

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Research

14 pages, 550 KiB  
Article
Comparison of Survival Outcomes between Radical Antegrade Modular Pancreatosplenectomy and Conventional Distal Pancreatosplenectomy for Pancreatic Body and Tail Cancer: Korean Multicenter Propensity Score Match Analysis
by Jaewoo Kwon, Huisong Lee, Hongbeom Kim, Sung Hyun Kim, Jae Do Yang, Woohyung Lee, Jun Suh Lee, Sang Hyun Shin and Hee Joon Kim
Cancers 2024, 16(8), 1546; https://doi.org/10.3390/cancers16081546 - 18 Apr 2024
Viewed by 864
Abstract
(1) Background: The aim of this study was to compare the survival benefit of radical antegrade modular pancreatosplenectomy (RAMPS) with conventional distal pancreatosplenectomy (cDPS) in left-sided pancreatic cancer. (2) Methods: A retrospective propensity score matching (PSM) analysis was conducted on 333 patients who [...] Read more.
(1) Background: The aim of this study was to compare the survival benefit of radical antegrade modular pancreatosplenectomy (RAMPS) with conventional distal pancreatosplenectomy (cDPS) in left-sided pancreatic cancer. (2) Methods: A retrospective propensity score matching (PSM) analysis was conducted on 333 patients who underwent RAMPS or cDPS for left-sided pancreatic cancer at four tertiary cancer centers. The study assessed prognostic factors and compared survival and operative outcomes. (3) Results: After PSM, 99 patients were matched in each group. RAMPS resulted in a higher retrieved lymph node count than cDPS (15.0 vs. 10.0, p < 0.001). No significant differences were observed between the two groups in terms of R0 resection rate, blood loss, hospital stay, or morbidity. The 5-year overall survival rate was similar in both groups (cDPS vs. RAMPS, 44.4% vs. 45.2%, p = 0.853), and disease-free survival was also comparable. Multivariate analysis revealed that ASA score, preoperative CA19-9, histologic differentiation, R1 resection, adjuvant treatment, and lymphovascular invasion were significant prognostic factors for overall survival. Preoperative CA19-9, histologic differentiation, T-stage, adjuvant treatment, and lymphovascular invasion were independent significant prognostic factors for disease-free survival. (4) Conclusions: Although RAMPS resulted in a higher retrieved lymph node count, survival outcomes were not different between the two groups. RAMPS was a surgical option to achieve R0 resection rather than a standard procedure. Full article
(This article belongs to the Special Issue The Progress of Pancreatectomy for Pancreatic Cancer Treatment)
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Pancreatectomy requiring Celiac Axis Resection and Reconstruction for Locally Advanced Pancreatic cancer
Authors: Satoshi Mizutani; Nobuhiko Taniai; Takahiro Haruna; Hiroyasu Furuki; Hideyuki Takata; Junji Ueda; Masato Yoshioka; Takayuki Aimoto; Yoshiharu Nakamura*; Hiroshi Yoshida**
Affiliation: Digestive Surgery, Nippon Medical School Musashikosugi Hospital. *Department of Surgery, Nippon Medical School Chiba Hokuso Hospital **Department of Surgery, Nippon Medical School 1-383 Kosugimachi, Nakahara, Kawasaki, Kanagawa. Japan. 211-8533

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