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Cancers
Special Issues
Advances in Tumor Vascular Imaging
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Advances in Tumor Vascular Imaging

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Causes, Screening and Diagnosis".

Deadline for manuscript submissions: 30 August 2025 | Viewed by 1261

Special Issue Editor

Dr. Eiichi Ishikawa

E-Mail Website
Guest Editor
Department of Neurosurgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
Interests: neurosurgery; glioma oncology/surgery; immunotherapy; particle radiation therapy (proton; boron neutron capture therapy)
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Intralesional (tumoral) blood vessels of neoplasms, as well as feeding arteries and draining veins, are essential for nutrient supply, the discharge of waste products, and the invasion and remote metastasis of tumor cells. There are strong correlations between tumor viability and their vascularity in various tumors. Measurement of tumor vascularity is useful not only in tumor diagnosis and treatment efficacy determination, but also in surgical planning to prevent serious bleeding. For example, external irradiations such as stereotactic radiosurgery, some embolic substances and several molecular-targeting drugs, including bevacizumab (anti-VEGF antibody), can decrease tumor vascularity; therefore, their measurement is useful in determining efficacy. Various challenges have been posed by imaging-using techniques such as magnetic resonance imaging (MRI), computed tomography (CT), angiography and single-photon ECT (SPECT) in the quantification of tumor vascularity and identification of vascular features including arterial feeding vessels and tumor neovascularization. More recently, PET imaging and other imaging modalities have also been used to detect tumor vascularity.

In this Special Issue, we welcome original papers and review articles that provide an overview of the latest advances and future challenges in tumor vascular imaging for the diagnosis and treatment of various neoplasms and neoplasmic mimics.

Dr. Eiichi Ishikawa
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (1 paper)

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Review

15 pages, 2776 KiB  
Review
Preoperative Vascular and Cranial Nerve Imaging in Skull Base Tumors
by Akinari Yamano, Masahide Matsuda and Eiichi Ishikawa
Cancers 2025, 17(1), 62; https://doi.org/10.3390/cancers17010062 - 28 Dec 2024
Viewed by 679
Abstract
Skull base tumors such as meningiomas and schwannomas are often pathologically benign. However, surgery for these tumors poses significant challenges because of their proximity to critical structures such as the brainstem, cerebral arteries, veins, and cranial nerves. These structures are compressed or encased [...] Read more.
Skull base tumors such as meningiomas and schwannomas are often pathologically benign. However, surgery for these tumors poses significant challenges because of their proximity to critical structures such as the brainstem, cerebral arteries, veins, and cranial nerves. These structures are compressed or encased by the tumor as they grow, increasing the risk of unintended injury to these structures, which can potentially lead to severe neurological deficits. Preoperative imaging is crucial for assessing the tumor size, location, and its relationship with adjacent vital structures. This study reviews advanced imaging techniques that allow detailed visualization of vascular structures and cranial nerves. Contrast-enhanced computed tomography and digital subtraction angiography are optimal for evaluating vascular structures, whereas magnetic resonance imaging (MRI) with high-resolution T2-weighted images and diffusion tensor imaging are optimal for evaluating cranial nerves. These methods help surgeons plan tumor resection strategies, including surgical approaches, more precisely. An accurate preoperative assessment can contribute to safe tumor resection and preserve neurological function. Additionally, we report the MRI contrast defect sign in skull base meningiomas, which suggests cranial nerve penetration through the tumor. This is an essential finding for inferring the course of cranial nerves completely encased within the tumor. These preoperative imaging techniques have the potential to improve the outcomes of patients with skull base tumors. Furthermore, this study highlights the importance of multimodal imaging approaches and discusses future directions for imaging technology that could further develop preoperative surgical simulations and improve the quality of complex skull base tumor surgeries. Full article
(This article belongs to the Special Issue Advances in Tumor Vascular Imaging)
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