Regulators of Breast Cancer Metastasis
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Metastasis".
Deadline for manuscript submissions: 30 June 2025 | Viewed by 4138
Special Issue Editors
Interests: chromatin organization; genome organizers; DNA structure; transcriptional regulation; epigenetics; cancer metastasis; cancer treatment; cancer diagnosis and prognosis; development
Special Issue Information
Dear Colleagues,
Targeted therapies for breast cancer have made major advances in recent years. Some therapies known as antibody-drug conjugates can prolong survival of late-stage breast cancer on average of 6-month improvement in prolongation compared to traditional chemotherapy alone. Despite the significant improvement in therapies, metastasis is still the major cause of death from cancer and metastatic breast cancer remains the second leading cause of cancer-associated death of women in the United States. Although breast cancer is known to be a highly heterogeneous disease, it remains true that cancer undergoes progression with time and many acquire the metastatic phenotypes eventually despite the treatment. Therefore, it is important to understand more deeply about the regulatory mechanisms underlying the metastatic phenotypes so that in the future, more effective therapies can be developed to prevent or inhibit cancer progression toward metastasis and recurrence. In this issue, we aim to address regulation of breast cancer metastasis from broad angles, such as key molecules (e.g. proteins, non-coding RNAs, chemicals), epigenetic and transcriptional regulators, signaling pathways, extracellular environment at primary site (i.e., tumor microenvironment) and distant metastasis site (i.e., metastatic niche), metabolism, immunity, microbiome and aging. Technologies to identify regulators and mechanisms underlying cancer progression are also crucial to develop. We aim to bring together scientists specialized in different approaches for cancer research in this issue to provide the current perspectives with regards to breast cancer metastasis. We wish to invite review articles and original research studies, focusing on the molecular mechanisms underlying breast cancer progression.
Prof. Dr. Terumi Kohwi-Shigematsu
Dr. Saori Furuta
Guest Editors
Manuscript Submission Information
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Keywords
- tumor progression regulators
- metastasis
- tumor microenvironment
- biomarkers for recurrence
- transcriptional regulation
- chromatin structure
- epigenetics
- cancer metabolism
- cancer immunity
- microbiome
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