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Cancers
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Novel Developments in Invasive Lobular Breast Cancer: Diagnosis, Prognosis and...
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Novel Developments in Invasive Lobular Breast Cancer: Diagnosis, Prognosis and Therapy

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Causes, Screening and Diagnosis".

Deadline for manuscript submissions: 1 March 2025 | Viewed by 7007

Special Issue Editors

Dr. Lubna Khaldi

E-Mail Website
Guest Editor
Department of Pathology, Saint Savvas Anticancer Hospital of Athens, 11522 Athens, Greece
Interests: pathology; bone; soft tissue; breast cancer; metabolic bone disease; bone histomorphometry
Dr. Nektarios Koufopoulos

E-Mail Website
Guest Editor
Second Department of Pathology, "Attikon" University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece
Interests: breast cancer; invasive lobular carcinoma; pathology; diagnosis

Special Issue Information

Dear Colleagues,

Invasive lobular carcinoma is the most common special subtype of invasive breast carcinoma. In addition to its specific morphology, it has different clinical, imaging, molecular, and treatment features compared to invasive breast carcinoma of no special type, as well as other special histologic subtypes.

Recent developments in this field include the recognition of novel subtypes.

We are pleased to invite you to contribute articles to this Special Issue, which aims to add to existing knowledge concerning the diagnosis, prognosis, and treatment of invasive lobular breast cancer. In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following: clinical, imaging, pathologic, molecular, and treatment features of invasive lobular carcinoma.

We look forward to receiving your contributions.

Dr. Lubna Khaldi
Dr. Nektarios Koufopoulos
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • invasive lobular carcinoma
  • imaging
  • diagnosis
  • pathology
  • tumor microenvironment
  • treatment
  • metastasis

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Published Papers (3 papers)

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Research

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16 pages, 3054 KiB  
Article
Deciphering the Clinical Behaviour of Invasive Lobular Carcinoma of the Breast Defines an Aggressive Subtype
by Shorouk Makhlouf, Nehal M. Atallah, Susanna Polotto, Andrew H. S. Lee, Andrew R. Green and Emad A. Rakha
Cancers 2024, 16(10), 1893; https://doi.org/10.3390/cancers16101893 - 16 May 2024
Viewed by 1439
Abstract
Background: Invasive lobular carcinoma (ILC), the most common special type of breast cancer (BC), has unique clinical behaviour and is different from invasive ductal carcinoma of no special type (IDC-NST). However, ILC further comprises a diverse group of tumours with distinct features. This [...] Read more.
Background: Invasive lobular carcinoma (ILC), the most common special type of breast cancer (BC), has unique clinical behaviour and is different from invasive ductal carcinoma of no special type (IDC-NST). However, ILC further comprises a diverse group of tumours with distinct features. This study aims to examine the clinicopathological and prognostic features of different variants of ILC, with a particular focus on characterising aggressive subtypes. Methods: A large (n = 7140) well-characterised and histologically reviewed BC cohort with treatment and long-term follow-up data was investigated. The cohort was classified based on the WHO classification of tumours into main histological subtypes, including ILC and IDC-NST. ILCs were further classified into variants. Clinicopathological parameters and patient outcomes in terms of BC-specific survival (BCSS) and disease-free survival (DFS) were evaluated. Results: ILC constituted 11% of the cohort. The most common non-classic ILC variants were pleomorphic (pILC) and solid (sILC), constituting 19% of ILC. Compared to classic and related variants (alveolar, trabecular, papillary, and tubulolobular; cILC), pILC and sILC variants were associated with aggressive tumour characteristics. The histologic grade of ILC was an important prognostic variable. The survival patterns identified an aggressive ILC subtype encompassing pILC and high-grade sILC. These tumours, which comprised 14% of the cases, were associated with clinicopathological characteristics of poor prognosis and had high BC-specific death and recurrence rates compared not only to cILC (p < 0.001) but also to IDC-NST (p = 0.02) patients. Contrasting this, cILC patients had significantly longer BCSS and DFS than IDC-NST patients in the first 10 to 15 years of follow-up. Adjuvant chemotherapy did not improve the outcome of patients with aggressive ILC subtypes. Conclusions: pILC and high-grade sILC variants comprise an aggressive ILC subtype associated with poor prognostic characteristics and a poor response to chemotherapy. These results warrant confirmation in randomised clinical trials. Full article
(This article belongs to the Special Issue Novel Developments in Invasive Lobular Breast Cancer: Diagnosis, Prognosis and Therapy)
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17 pages, 6632 KiB  
Article
Histological Patterns and Mammographic Presentation of Invasive Lobular Carcinoma Show No Obvious Associations
by Gábor Cserni, Rita Bori, Éva Ambrózay and Orsolya Serfőző
Cancers 2024, 16(9), 1640; https://doi.org/10.3390/cancers16091640 - 24 Apr 2024
Viewed by 1171
Abstract
Invasive lobular carcinoma of the breast has different mammographic appearances, including spiculated or lobulated masses, architectural distortion, increased breast density, and the possibility of also being occult. Histologically, the morphology is also variable, as several patterns have been described beside the classical one, [...] Read more.
Invasive lobular carcinoma of the breast has different mammographic appearances, including spiculated or lobulated masses, architectural distortion, increased breast density, and the possibility of also being occult. Histologically, the morphology is also variable, as several patterns have been described beside the classical one, including the solid, the alveolar, the trabecular, the one with tubular elements, and others. Of 146 ILC cases, 141 were reviewed for mammographic appearance and 136 for histological patterns by two radiologist and two pathologists, respectively; 132 common cases were analyzed for possible associations between mammographic presentation and the histological patterns. Interobserver agreement on the presence or absence of a given mammographic morphology ranged from 45% (increased density) to 95% (occult lesion); the most common radiomorphology was that of a spiculated mass. Interobserver agreement on the presence or absence of a given histological pattern ranged between 79% (solid) and 99% (classical) but was worse when semi-quantification was also included. The mammography–pathology correlation was less than optimal. Multifocality was more commonly detected by histology. The identification of a mammographic mass lesion often coincided with a mass-like lesion on the histological slides and vice versa, but nearly half of the mammographically occult lesions were felt to have masses on histological slides assessed grossly. Histological patterns showed no obvious associations with one or the other mammographic appearance. Full article
(This article belongs to the Special Issue Novel Developments in Invasive Lobular Breast Cancer: Diagnosis, Prognosis and Therapy)
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Review

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28 pages, 4112 KiB  
Review
Lobular Carcinoma of the Breast: A Comprehensive Review with Translational Insights
by Harsh Batra, Jason Aboudi Mouabbi, Qingqing Ding, Aysegul A. Sahin and Maria Gabriela Raso
Cancers 2023, 15(22), 5491; https://doi.org/10.3390/cancers15225491 - 20 Nov 2023
Cited by 7 | Viewed by 3747
Abstract
The second most common breast carcinoma, invasive lobular carcinoma, accounts for approximately 15% of tumors of breast origin. Its incidence has increased in recent times due in part to hormone replacement therapy and improvement in diagnostic modalities. Although believed to arise from the [...] Read more.
The second most common breast carcinoma, invasive lobular carcinoma, accounts for approximately 15% of tumors of breast origin. Its incidence has increased in recent times due in part to hormone replacement therapy and improvement in diagnostic modalities. Although believed to arise from the same cell type as their ductal counterpart, invasive lobular carcinomas (ILCs) are a distinct entity with different regulating genetic pathways, characteristic histologies, and different biology. The features most unique to lobular carcinomas include loss of E-Cadherin leading to discohesion and formation of a characteristic single file pattern on histology. Because most of these tumors exhibit estrogen receptor positivity and Her2 neu negativity, endocrine therapy has predominated to treat these tumors. However novel treatments like CDK4/6 inhibitors have shown importance and antibody drug conjugates may be instrumental considering newer categories of Her 2 Low breast tumors. In this narrative review, we explore multiple pathological aspects and translational features of this unique entity. In addition, due to advancement in technologies like spatial transcriptomics and other hi-plex technologies, we have tried to enlist upon the characteristics of the tumor microenvironment and the latest associated findings to better understand the new prospective therapeutic options in the current era of personalized treatment. Full article
(This article belongs to the Special Issue Novel Developments in Invasive Lobular Breast Cancer: Diagnosis, Prognosis and Therapy)
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