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Cancers
Special Issues
Contemporary Management for Gallbladder Cancer: From Diagnosis to Treatment
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Contemporary Management for Gallbladder Cancer: From Diagnosis to Treatment

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: closed (15 October 2024) | Viewed by 1017

Special Issue Editor

Dr. Hiromichi Ito

E-Mail Website
Guest Editor
Division of Hepatobiliary and Pancreatic Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo 135-8550, Japan
Interests: biliary cancer; liver cancer; pancreatic cancer; liquid biopsy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Gallbladder cancer (GBCA) is a rare, but aggressive disease with a propensity for early invasion of the adjacent organs and dissemination to lymph nodes and peritoneal surfaces. As patients with GBCA often remain asymptomatic until the advanced stage, it has historically been considered an incurable disease with dismal prognosis, and the clinical attitude towards GBCA has been characterized by pessimism in the past. In recent decades, however, chemotherapy for biliary cancer has evolved and more effective regimens are more commonly used in the management of GBCA. Furthermore, along with recent increased use of computed tomography or abdominal ultrasound in general practice, the number of patients with GBCA incidentally discovered at the early stage has been increasing. Thus, in this Special Issue, we call for papers on the contemporary management for patients with GBCA and its outcomes. The scope includes modern multidisciplinary approaches for advanced GBCA, strategies for early GBCA, and other translational research for novel diagnostic/therapeutic strategies.

Dr. Hiromichi Ito
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gallbladder cancer
  • radical cholecystectomy
  • adjuvant chemotherapy
  • neoadjuvant therapy
  • incidental gallbladder cancer
  • multidisciplinary management
  • preoperative staging

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Published Papers (1 paper)

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Research

13 pages, 1158 KiB  
Article
Prognostic Factors in Patients Diagnosed with Gallbladder Cancer over a Period of 20 Years: A Cohort Study
by Nima Toussi, Krishna Daida, Michael Moser, Duc Le, Kimberly Hagel, Rani Kanthan, John Shaw, Adnan Zaidi, Haji Chalchal and Shahid Ahmed
Cancers 2024, 16(17), 2932; https://doi.org/10.3390/cancers16172932 - 23 Aug 2024
Viewed by 651
Abstract
Background: Gallbladder cancer (GBC) is an uncommon cancer. This study aimed to determine the outcomes of GBC in relation to geographic, demographic, and clinical factors in a Canadian province from 2000 to 2019. Methods: This population-based retrospective cohort study included all patients diagnosed [...] Read more.
Background: Gallbladder cancer (GBC) is an uncommon cancer. This study aimed to determine the outcomes of GBC in relation to geographic, demographic, and clinical factors in a Canadian province from 2000 to 2019. Methods: This population-based retrospective cohort study included all patients diagnosed with gallbladder cancer (GBC) in Saskatchewan, Canada, from 2000 to 2019. Cox proportional multivariate regression analysis was conducted to identify factors associated with poorer outcomes. Results: In total, 331 patients with a median age of 74 years and male–female ratio of 1:2 were identified. Of these patients, 305 (92%) had a pathological diagnosis of GBC. Among patients with documented staging data, 64% had stage IV disease. A total of 217 (66%) patients were rural residents, and 149 (45%) were referred to a cancer center. The multivariate analysis for patients with stage I–III GBC showed that stage III disease [hazard ratio (HR), 2.63; 95% confidence interval (CI), 1.09–6.34)] and urban residence (HR, 2.20; 95% CI, 1.1–4.39) were correlated with inferior disease-free survival. For all patients, stage IV disease (HR, 3.02; 95% CI, 1.85–4.94), no referral to a cancer center (HR, 2.64; 95% CI, 1.51–4.62), lack of surgery (HR, 1.63; 95% CI, 1.03–2.57), a neutrophil–lymphocyte ratio of >3.2 (HR, 1.57; 1.05–2.36), and age of ≥70 years (HR, 1.51; 95% CI, 1.04–2.19) were correlated with inferior overall survival. Conclusions: In this real-world context, the majority of patients with GBC were diagnosed at a late stage and were not referred to a cancer center. For those with early-stage GBC, living in an urban area and having stage III disease were linked to worse outcomes. Across all stages of GBC, stage IV disease, older age, absence of surgery, lack of referral to a cancer center, and a high neutrophil-to-lymphocyte ratio were associated with poorer survival. Full article
(This article belongs to the Special Issue Contemporary Management for Gallbladder Cancer: From Diagnosis to Treatment)
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