New Insights in Thoracic Sarcoma

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 1403

Special Issue Editor


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Guest Editor
Professor and Chair in Thoracic Surgery, Lung Clinic, Kliniken der Stadt Köln, University of Witten Herdecke, Cologne, Germany
Interests: thoracic oncology; sarcoma; surgery; lung perfusion; hyperthermic intrathoracic chemotherapy

Special Issue Information

Dear Colleagues,

Sarcomas are rare cancers deriving from mesenchymal cells and include over one hundred different histologic entities. Sarcoma may involve any structure throughout the body. Despite their rarity, Surgeons, Medical or Radiation Oncologists, Radiologists and Respirologists dealing with Thoracic Oncology will invariably encounter Thoracic Sarcomas as primary or secondary lesions. Primary thoracic sarcoma most commonly involve the chest wall, pleura, mediastinum and lung. Secondary lesions are most commonly seen in the pleura (pleural sarcomatosis) or in the pulmonary parenchyma. Awareness and identification of these rare entities as well as adequate diagnosis and treatment are of paramount importance for optimal outcome. 

We are pleased to invite you to participate in this Special Issue covering relevant aspects of Thoracic Sarcoma from diagnosis to treatment. Current as well as future therapies will also be discussed. 

This Special Issue aims to

  1. Describe the features and treatment of thoracic sarcomas based on their anatomic location: lung, pulmonary artery, mediastinum and chest wall.
  2. Discuss the potential of systemic treatment for thoracic sarcoma, applied locally (in-vivo lung perfusion-IVLP, Hyperthermic Intrathoracic Chemotherapy –HITOC).
  3. Discuss future systemic treatment beyond chemotherapy.

In this Special Issue, original research articles and reviews are welcome. 

Prof. Dr. Stéphane Collaud
Guest Editor

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Keywords

  • thoracic sarcoma
  • surgery
  • lung
  • chest wall
  • pleura
  • mediastinum
  • pulmonary artery
  • en bloc resection
  • chemotherapy
  • hyperthermic intrathoracic chemotherapy
  • HITOC
  • lung perfusion
  • IVLP

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Published Papers (1 paper)

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Research

13 pages, 3723 KiB  
Article
Outcome Analysis of Treatment Modalities for Thoracic Sarcomas
by Milos Sarvan, Harry Etienne, Lorenz Bankel, Michelle L. Brown, Didier Schneiter and Isabelle Opitz
Cancers 2023, 15(21), 5154; https://doi.org/10.3390/cancers15215154 - 26 Oct 2023
Cited by 1 | Viewed by 1078
Abstract
Background: Primary chest wall sarcomas are a rare and heterogeneous group of chest wall tumors that require multimodal oncologic and surgical therapy. The aim of this study was to review our experience regarding the surgical treatment of chest wall sarcomas, evaluating the short- [...] Read more.
Background: Primary chest wall sarcomas are a rare and heterogeneous group of chest wall tumors that require multimodal oncologic and surgical therapy. The aim of this study was to review our experience regarding the surgical treatment of chest wall sarcomas, evaluating the short- and long-term results. Methods: In this retrospective single-center study, patients who underwent surgery for soft tissue and bone sarcoma of the chest wall between 1999 and 2018 were included. We analyzed the oncologic and surgical outcomes of chest wall resections and reconstructions, assessing overall and recurrence-free survival and the associated clinical factors. Results: In total, 44 patients underwent chest wall resection for primary chest wall sarcoma, of which 18 (41%) received surgery only, 10 (23%) received additional chemoradiotherapy, 7% (3) received surgery with chemotherapy, and 30% (13) received radiotherapy in addition to surgery. No perioperative mortality occurred. Five-year overall survival was 51.5% (CI 95%: 36.1–73.4%), and median overall survival was 1973 days (CI 95% 1461; -). As determined in the univariate analysis, the presence of metastasis upon admission and tumor grade were significantly associated with shorter survival (p = 0.037 and p < 0.01, respectively). Five-year recurrence-free survival was 71.5% (95% CI 57.6%; 88.7%). Tumor resection margins and metastatic disease upon diagnosis were significantly associated with recurrence-free survival (p < 0.01 and p < 0.01, respectively). Conclusion: Surgical therapy is the cornerstone of the treatment of chest wall sarcomas and can be performed safely. Metastasis and high tumor grade have a negative influence on overall survival, while tumor margins and metastasis have a negative influence on local recurrence. Full article
(This article belongs to the Special Issue New Insights in Thoracic Sarcoma)
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