The Role of Immunity in the Tumor Microenvironment
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Tumor Microenvironment".
Deadline for manuscript submissions: closed (15 July 2024) | Viewed by 8021
Special Issue Editor
Special Issue Information
Dear Colleagues,
The tumor microenvironment (TME) is an intricate entity that varies between different tumor types and includes the interplay of different components, such as extracellular matrix, blood vessels, tumor cells, and immune cells. It is now well established that the tumor microenvironment plays a tremendous role in cancer progression and regulating therapeutic response. Of all the therapeutic modalities affected by the TME, immunotherapies are also influenced by the participation of different regulatory molecules from immune cells and components of the TME. The latest developments in the field of immunology have significantly improved the efficacy of diverse immunotherapies, such as monoclonal antibody (MAB) therapy, immune checkpoint blockade (ICB) therapy, vaccines, CAR-T therapy, etc., against cancer cells. However, the understanding of the immune system in the TME still requires an in-depth understanding as it is now well recognized that the presence of different innate and adaptive immune cells in the TME can provide both pro- and anti-tumorigenic immunity against cancer cells. Furthermore, recent studies have shown the presence of microbiota in the TME, and they can modulate the therapeutic response efficacy through the alterations of immunity against cancer cells. Therefore, a thorough knowledge of the role of immunity in the TME can have a great impact on increasing the efficacy of immunotherapeutic options in cancer treatment. Thus, this Special Issue invites manuscripts in the form of original research articles, reviews, etc., related to the role of immunity in the TME to ultimately broaden the understanding of how to target cancer cells efficiently.
Dr. Nand K Roy
Guest Editor
Manuscript Submission Information
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Keywords
- tumor microenvironment
- immunity
- immunotherapy
- microbiome
- immune checkpoint blockade (ICB) therapy
- vaccines
- CAR-T therapy
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