Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
8.0
4.5
Journals
Cancers
Special Issues
The State of the Art in the Diagnosis, Staging, Treatment...
share announcement

The State of the Art in the Diagnosis, Staging, Treatment and Prognosis of Gastrointestinal and Urogenital Malignancies

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Clinical Research of Cancer".

Deadline for manuscript submissions: 10 February 2025 | Viewed by 5020

Special Issue Editors

Dr. Agnieszka Kulczyńska-Przybik

E-Mail Website
Guest Editor
Department of Neurodegeneration Diagnostics, Medical University of Białystok, Waszyngtona 15 A St., 15-269 Bialystok, Poland
Interests: gastric cancer; diagnostics; inflammatory biomarkers; clinical outcomes
Special Issues, Collections and Topics in MDPI journals
Dr. Sara Pączek

E-Mail Website
Guest Editor
Department of Biochemical Diagnostics, University Hospital in Bialystok, Waszyngtona 15A St., 15-269 Bialystok, Poland
Interests: oncology; clinical chemistry; laboratory diagnostics; specific proteins; biomarkers

Special Issue Information

Dear Colleagues,

Gastrointestinal and urogenital cancers are a highly diverse group of diseases, which, due to the lack of multiple specific symptoms in their early stages, are one of the most common causes of death in the world. Despite the constant development of diagnostic and therapeutic methods, the number of cancers is constantly growing, and thus causes a huge physical, emotional and financial burden both for individuals and healthcare systems. Gastric cancer is one of the most common causes of cancer-related deaths worldwide, whereas prostate cancer is the second most common malignancy among men. The main reason for treatment failure in patients with gastric cancer is a late diagnosis, with many patients not presenting any symptoms in advanced stages. Moreover, the occurrence of chemoresistance and the presence of metastases are important factors leading to the death of oncological patients. Therefore, there is an urgent need to develop new diagnostic and prognostic alternatives, as well as innovative therapeutic approaches that would, on the one hand, allow for the early detection of cancer and, on the other hand, would predict the behavior of the cancer and the risk of recurrence of the disease.

We are pleased to invite you to submit articles related to the aim of this Special Issue, which includes, among others, issues regarding advances in biomarkers to determine cancer diagnostic, prognostic and therapeutic options in gastrointestinal cancers (esophageal cancer, gastric cancer, liver cancer, pancreatic cancer and colorectal cancer) and urogenital cancers (bladder cancer, kidney cancer, prostate cancer and testicular cancer).

In this Special Issue, we encourage authors to publish basic and clinical research manuscripts, and we will accept both original research and review articles.

We look forward to receiving your contributions.

Dr. Agnieszka Kulczyńska-Przybik
Dr. Sara Pączek
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (3 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Other

26 pages, 1858 KiB  
Article
A Comparison of Established Diagnostic Criteria for Cachexia and Their Impacts on Prognostication in Patients with Oesophagogastric Cancer
by Leo R. Brown, Maria Soupashi, Michael S. Yule, Cathleen M. Grossart, Donald C. McMillan, Barry J. A. Laird, Stephen J. Wigmore and Richard J. E. Skipworth
Cancers 2025, 17(3), 448; https://doi.org/10.3390/cancers17030448 - 28 Jan 2025
Viewed by 304
Abstract
Background: Cachexia is common in patients with oesophagogastric cancer. The syndrome is characterised by tissue wasting (muscle and fat), anorexia, and reduced physical function, which result from complex interactions between the tumour and its host. Heterogeneity in the diagnostic criteria used for cachexia [...] Read more.
Background: Cachexia is common in patients with oesophagogastric cancer. The syndrome is characterised by tissue wasting (muscle and fat), anorexia, and reduced physical function, which result from complex interactions between the tumour and its host. Heterogeneity in the diagnostic criteria used for cachexia has hindered their clinical utilisation. This study aimed to compare the two established cachexia definitions (Fearon’s consensus definition and the Global Leadership Initiative on Malnutrition [GLIM] criteria) and their relationships with survival in patients with oesophagogastric cancer. Methods: Consecutive patients newly diagnosed with oesophagogastric cancer (January 2019 to December 2020) were identified from a prospective regional database. Involuntary weight loss, BMI, CT body composition analyses, and neutrophil–lymphocyte ratios were recorded at clinical staging. These data were used to assess patients for cachexia according to Fearon and GLIM diagnostic criteria. The primary outcome of interest was overall survival. Results: Overall, 465 patients (66.9% male, median 71 years) were diagnosed with oesophagogastric cancer during the 2-year study period. Cachectic proportions differed between definitions (Fearon: 59.1% vs. GLIM: 44.1%), and only 49.1% of the 322 patients who met one set of diagnostic criteria were cachectic according to both. Patients who met the GLIM criteria were significantly more comorbid and had a poorer performance status; however, no such difference was evident when using the Fearon definition. Those patients who met either set of diagnostic criteria had shorter survival than those who met neither (p < 0.001). Following adjustment for confounders, GLIM-defined cachexia was more strongly associated with reduced survival (aHR: 1.57 [95% CI: 1.25–1.96], p < 0.001) than Fearon-defined cachexia (aHR: 1.41 [95% CI: 1.13–1.76], p = 0.002). Patients who only met the Fearon diagnostic criteria had prolonged survival (median: 363 days) when compared to those who met only GLIM (median: 158 days) or both definitions (median: 120 days). A secondary analysis of those patients who met the GLIM diagnostic criteria (n = 205) compared the three potential phenotypical criteria used in this definition. Only reduced muscle mass, and not low BMI or weight loss, was associated with poorer survival (aHR: 1.88 [95% CI: 1.15–3.07], p = 0.012) in this group. Conclusions: Cancer cachexia is strongly associated with shortened survival in patients with oesophagogastric cancer. Classification using the GLIM criteria provides more effective prognostication and this definition should be utilised in multidisciplinary patient care. Full article
(This article belongs to the Special Issue The State of the Art in the Diagnosis, Staging, Treatment and Prognosis of Gastrointestinal and Urogenital Malignancies)
12 pages, 1630 KiB  
Article
Endoscopic Ultrasound-Guided Fine-Needle Biopsy Versus Aspiration for Tissue Sampling Adequacy for Molecular Testing in Pancreatic Ductal Adenocarcinoma
by Wael T. Mohamed, Vinay Jahagirdar, Fouad Jaber, Mohamed K. Ahmed, Ifrah Fatima, Thomas Bierman, Zhuxuan Fu, Philip G. Jones, Amira F. Hassan, Erin Faber, Wendell K. Clarkston, Hassan Ghoz, Ossama W. Tawfik and Sreeni Jonnalagadda
Cancers 2024, 16(4), 761; https://doi.org/10.3390/cancers16040761 - 12 Feb 2024
Cited by 1 | Viewed by 2662
Abstract
Background and Aims: There is limited literature on sample adequacy for molecular testing in pancreatic ductal adenocarcinoma obtained via endoscopic ultrasound (EUS) fine-needle aspiration (FNA) versus EUS fine-needle biopsy (FNB). We aimed to compare these two modalities regarding sample adequacy for molecular and [...] Read more.
Background and Aims: There is limited literature on sample adequacy for molecular testing in pancreatic ductal adenocarcinoma obtained via endoscopic ultrasound (EUS) fine-needle aspiration (FNA) versus EUS fine-needle biopsy (FNB). We aimed to compare these two modalities regarding sample adequacy for molecular and genomic sequencing. Methods: We reviewed all patients with pancreatic ductal adenocarcinoma who underwent EUS at Saint Luke’s Hospital from 2018 to 2021. The patients were categorized based on the method of EUS tissue acquisition, specifically FNA or FNB. A comprehensive evaluation was conducted for all cases by cytotechnologists. Results: Out of 132 patients who underwent EUS-guided biopsies, 76 opted for FNA, 48 opted for FNB, and 8 opted for a combination of both. The average number of passes required for FNB and FNA was 2.58 ± 1.06 and 2.49 ± 1.07, respectively (p = 0.704), indicating no significant difference. Interestingly, 71.4% (35) of FNB-obtained samples were deemed adequate for molecular testing, surpassing the 32.1% (26) adequacy observed with FNA (p < 0.001). Additionally, 46.4% (26) of FNB-obtained samples were considered adequate for genomic testing, a notable improvement over the 23.8% (20) adequacy observed with FNA (p = 0.005). Conclusion: Although the number of passes required for cytologic diagnosis did not differ significantly between EUS-FNB and EUS-FNA, the former demonstrated superiority in obtaining samples adequate for molecular testing. Tumor surface area and cellularity were crucial parameters in determining sample adequacy for molecular testing, irrespective of the chosen tissue acquisition modality. Full article
(This article belongs to the Special Issue The State of the Art in the Diagnosis, Staging, Treatment and Prognosis of Gastrointestinal and Urogenital Malignancies)
►▼ Show Figures

Figure 1

Other

Jump to: Research

16 pages, 752 KiB  
Systematic Review
The Role of Pentraxin 3 in Gastrointestinal Cancers
by Monika Zajkowska and Barbara Mroczko
Cancers 2023, 15(24), 5832; https://doi.org/10.3390/cancers15245832 - 14 Dec 2023
Cited by 2 | Viewed by 1561
Abstract
Gastrointestinal cancers have become a huge problem worldwide as the number of new cases continues to increase. Due to the growing need to explore new biomarkers and therapeutic targets for the detection and treatment of cancerous lesions, we sought to elucidate the role [...] Read more.
Gastrointestinal cancers have become a huge problem worldwide as the number of new cases continues to increase. Due to the growing need to explore new biomarkers and therapeutic targets for the detection and treatment of cancerous lesions, we sought to elucidate the role of Pentraxin-3 in the progression of cancerous lesions, as it is involved in the process of angiogenesis and inflammation. Statistically significant changes in the concentration of this parameter have emerged in many gastrointestinal cancer patients. Moreover, it is related to the advancement of cancer, as well as processes leading to the development of those changes. In the case of studies concerning tissue material, both increased and decreased tissue expression of the tested parameter were observed and were dependent on the type of cancer. In the case of cell lines, both human and animal, a significant increase in Pentraxin 3 gene expression was observed, which confirmed the changes observed at the protein level. In conclusion, it can be assumed that PTX3, both at the level of gene expression and protein concentrations, is highly useful in the detection of gastrointestinal cancers, and its use as a biomarker and/or therapeutic target may be useful in the future. Full article
(This article belongs to the Special Issue The State of the Art in the Diagnosis, Staging, Treatment and Prognosis of Gastrointestinal and Urogenital Malignancies)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-3
Back to TopTop