New Approaches in the Treatment of Hepatocellular Carcinoma and Liver Tumor

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 1035

Special Issue Editors


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Guest Editor
Ospedale General Regionale F. Miulli, Acquaviva delle Fonti, Italy
Interests: radiology; oncology

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Guest Editor
New Approaches in the Treatment of Hepatocellular Carcinoma and Liver Tumor, National and Kapodistrian University of Athens, Athens, Greece
Interests: radiology

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Guest Editor
Unit of Hepato-Pancreatic-Biliary Surgery, "F. Miulli" General Regional Hospital, 70021 Acquaviva Delle Fonti, Italy
Interests: gastroiontestinal cancers; robotic surgery; surgical oncology
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Special Issue Information

Dear Colleagues,

Hepatocellular carcinoma (HCC) is the most frequently observed primary malignant liver tumor and is a major cause of worldwide mortality. Despite the advent of screening programs for patients with known risk factors, a substantial number of patients are ineligible for curative surgery at presentation. Thus, locoregional treatments now hold a pivotal role in HCC management; trans-arterial chemoembolization, percutaneous ablation and more recently selective internal radiation therapy are often the first-line treatments for selected stages of HCC or serve as a bridge to liver transplantation.

The goal of this Research Topic is to provide a comprehensive overview of various image-guided minimally invasive therapies available for HCC with an assessment of novel combination regimens and future perspectives, to better investigate the role of radiology in the assessment of responses to locoregional treatments for HCC. We welcome you to submit basic and clinical research articles and reviews.

Dr. Riccardo Inchingolo
Dr. Stavros Spiliopoulos
Dr. Riccardo Memeo
Guest Editors

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Keywords

  • hepatocellular carcinoma
  • cirrhosis
  • liver
  • interventional oncology
  • trans-arterial chemo embolization
  • selective internal radiation therapy
  • ablation
  • radiology

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Published Papers (1 paper)

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Research

11 pages, 3964 KiB  
Article
Adverse Events in Targeted Therapy for Unresectable Hepatocellular Carcinoma Predict Clinical Outcomes
by Kenji Imai, Koji Takai, Masashi Aiba, Shinji Unome, Takao Miwa, Tatsunori Hanai, Atsushi Suetsugu and Masahito Shimizu
Cancers 2024, 16(18), 3150; https://doi.org/10.3390/cancers16183150 - 14 Sep 2024
Viewed by 848
Abstract
To assess the impact of adverse event (AE) severity, caused by targeted therapy, on overall survival (OS) and progression-free survival (PFS) in patients with unresectable hepatocellular carcinoma (HCC), a total of 183 patients with HCC treated with atezolizumab plus bevacizumab (40), lenvatinib (57), [...] Read more.
To assess the impact of adverse event (AE) severity, caused by targeted therapy, on overall survival (OS) and progression-free survival (PFS) in patients with unresectable hepatocellular carcinoma (HCC), a total of 183 patients with HCC treated with atezolizumab plus bevacizumab (40), lenvatinib (57), sorafenib (79), cabozantinib (3), ramucirumab (3), and regorafenib (1) were included in this study. Age-, AFP-, and ALBI score-adjusted hazard ratios (HRs) of AE grades 1 to 3 versus grade 0 for OS and PFS were calculated using Cox proportional hazards models. The linear trend of the HRs was assessed by calculating the p values for this trend. The most common AEs were appetite loss (AE grade 0/1/2/3 = 97/23/55/12), general fatigue (102/31/44/6), hypertension (120/6/40/17), hand-foot syndrome (HFS) (135/21/24/3), proteinuria (140/13/16/14), and hypothyroidism (148/12/23/0). The adjusted HRs for OS of these AEs were 0.532–1.450–2.361 (p for trend 0.037), 1.057–1.691–3.364 (p for trend 0.004), 1.176–0.686–0.281 (p for trend 0.002), 0.639–0.759–1.820 (p for trend 0.462), 1.030–0.959–0.147 (p for trend 0.011), and 0.697–0.609 (p for trend 0.119), respectively. Those for PFS of the corresponding AEs were 0.592–1.073–2.811 (p for trend 0.255), 1.161–1.282–4.324 (p for trend 0.03), 0.965–0.781–0.655 (p for trend 0.095), 0.737–0.623–2.147 (p for trend 0.153), 1.061–0.832–0.800 (p for trend 0.391), and 1.412–0.560 (p for trend 0.081), respectively. Appetite loss and general fatigue negatively affected clinical outcomes, whereas hypertension, HFS, proteinuria, and hypothyroidism had positive effects. Full article
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