Heat Shock Proteins in Cancers
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Tumor Microenvironment".
Deadline for manuscript submissions: 15 December 2024 | Viewed by 3120
Special Issue Editors
Interests: thermoregulation; adaptive physiology; physical activity; rehabilitation; sports medicine; aging
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Special Issue Information
Dear Colleagues,
Heat shock proteins (HSPs), molecular chaperone proteins, are known to be one of the main proteins that play a role in maintaining cell homeostasis. They are involved in the process of protein folding and its maturation; they also play a role in cell proliferation and differentiation, as well as in the process of carcinogenesis. The increased expression of HSPs that occurs during the neoplastic process favors the creation of an environment suitable for the development of a neoplastic tumor, during which cellular homeostasis is dysregulated. HSPs are of multidirectional importance in the development of cancer, including by increasing their proliferation, promoting the avoidance of antigrowth signals and escaping from cell death, inhibiting cell aging, increasing angiogenesis and metastasis, or avoiding responses from the immune system.
Due to their properties, HSPs are an alternative to anticancer therapy, e.g., when tumor cells become resistant to currently available treatment. The inhibition of HSPs in cancer therapy may provide promising results, among others, by eliminating proteins responsible for tumor growth. Tumor-specific HSPs may be good prognostic markers of an organism's response to treatment.
Understanding the exact mechanisms of HSP (intracellular and extracellular) action is important due to the development of alternative, but also more precise methods of treatment of various types of cancers of clinical significance.
Prof. Dr. Anna Lubkowska
Dr. Weronika Ratajczak
Guest Editors
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Keywords
- heat shock proteins
- extracellular HSPs
- intracellular HSPs
- cancer
- cancer therapy
- biomarkers
- molecular targets
- cancer biology
- cancer pharmacology
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