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Cancers
Special Issues
Paradigm Shifts in Gynaecological Oncology Surgery
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Paradigm Shifts in Gynaecological Oncology Surgery

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Epidemiology and Prevention".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 854

Special Issue Editor

Dr. Faiza Gaba

E-Mail Website
Guest Editor
1. Department of Gynaecological Oncology, The Royal Marsden Hospital, London SW3 6JJ, UK
2. Institute of Applied Health Sciences, University of Aberdeen, Aberdeen AB24 3FX, UK
Interests: ovarian cancer; gynaecological oncology; abdominal surgery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Over the past decade, there have been significant advances and developments in surgical gynecological oncology. Whilst improved understanding of tumor biology, advances in genomics, and novel chemotherapeutic agents have all contributed to increasing cancer survival, surgery remains the cornerstone of curative treatment in gynecological oncology. Our patients facing surgery experience the ongoing balancing act between ultraradical surgery to prolong survival and maintaining quality of life. We welcome submissions that cover any relevant topics in the areas of gynecological cancer surgery, perioperative risk management, cancer survivorship, and associated health economics of women’s cancers, including ovarian, endometrial, cervical, vulval/vaginal, and breast cancer.

All submitted articles will undergo a rigorous peer review process to ensure the highest scientific quality and relevance to the field. We encourage contributions from researchers, clinicians, and experts in the field of surgical gynecological oncology.

Should you have any questions, require further information, or need any assistance, please do not hesitate to reach out to us. We are here to support and facilitate your participation in this Special Issue.

Thank you for your attention to this matter, and we look forward to receiving your valuable submissions.

Dr. Faiza Gaba
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gynecological surgery
  • genomics risk management
  • survivorship health economics

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Published Papers (1 paper)

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Research

13 pages, 690 KiB  
Article
Intraoperative Radiation Therapy for Recurrent Cervical and Endometrial Cancer: Predicting Morbidity and Mortality in a Contemporary Cohort
by Lindsay N. Howlett, Priyal P. Fadadu, Leah O. Grcevich, Angela J. Fought, Michaela E. McGree, Andrea Giannini, Kristina A. Butler, Lucia Tortorella, Amanda A. Marnholtz, Michael G. Haddock, Allison E. Garda, Carrie L. Langstraat, Sean C. Dowdy and Amanika Kumar
Cancers 2024, 16(21), 3628; https://doi.org/10.3390/cancers16213628 - 28 Oct 2024
Viewed by 633
Abstract
Background/Objectives: Our objective was to describe the use of intraoperative radiation therapy (IORT) for the treatment of recurrent/persistent cervical or endometrial cancer and assess predictors of postoperative complications and 3-year mortality. Methods: In this multi-site retrospective study, data were abstracted for recurrent/persistent endometrial [...] Read more.
Background/Objectives: Our objective was to describe the use of intraoperative radiation therapy (IORT) for the treatment of recurrent/persistent cervical or endometrial cancer and assess predictors of postoperative complications and 3-year mortality. Methods: In this multi-site retrospective study, data were abstracted for recurrent/persistent endometrial or cervical cancer patients who underwent IORT from June 2004 to May 2021. Complications were graded on the six-point Accordion scale. Variables associated with complications were analyzed with univariate logistic regression, while variables associated with death within 3 years were analyzed with Cox proportional hazards modeling. Survival was analyzed with the Kaplan–Meier method. Results: Eighty patients had planned IORT for recurrent/persistent endometrial (n = 35) or cervical cancer (n = 45). The mean age of the cohort was 56.8 years (SD = 13.7), and the median disease-free interval from primary disease to recurrence was 20.0 months (IQR 10.0–63.1). The overall survival at 3 years was 48.6% (95% CI: 38.3–61.6%) with a median survival of 2.8 years. Within 30 days postoperative, 16 patients (20.1%) had grade 3–5 complications and one death (1.3%) occurred. Factors associated with grade 3+ complication included ECOG PS 2–3 (OR 18.00, p = 0.04), neoadjuvant chemotherapy and/or immunotherapy (OR 6.98, p < 0.01), and pelvic sidewall involvement (OR 8.80, p = 0.04). Factors associated with death within 3 years of surgery included ECOG PS 2–3 (HR 8.97, p < 0.01), neoadjuvant chemotherapy and/or immunotherapy (HR 2.34, p = 0.03), whether exenteration was performed (HR 2.64, p = 0.01), and positive resection margin (HR 3.37, p < 0.01). Conclusions: In well-selected patients, IORT is a feasible and safe option for the treatment of recurrent/persistent gynecologic malignancy with an appreciable survival benefit. Full article
(This article belongs to the Special Issue Paradigm Shifts in Gynaecological Oncology Surgery)
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