Advances in Renal Cell Carcinoma

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 31 March 2025 | Viewed by 624

Special Issue Editors


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Guest Editor
Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Carl-Neuberg Str. 1, 30625 Hannover, Germany
Interests: real world analysis; urogenital cancers; sarcoma; head and neck cancers; renal cell carcinoma

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Guest Editor
Department of Hematology and Oncology, Städtisches Klinikum Braunschweig, Celler Street 38, 308114 Braunschweig, Germany
Interests: lung cancer; renal cell carcinoma; real world analysis; risk factors

Special Issue Information

Dear Colleagues,

Medical treatment of renal cell carcinoma has experienced groundbreaking improvements over the last few decades. Evolving from an unselected immunotherapy with interferons and a type of treatment that only benefits very few patients, a broad range of highly effective therapies are available nowadays, including targeted therapies and immunotherapy. Treatment for this malignancy has demonstrated unparallel improvements in survival for patients who are deemed to be incurable. With the advances in medical treatment, an improved understanding of the diverse biological causes of the diseases and the multimodal care of RCC patients with individualized local and medical treatment sequencings represent the future scientific challenges.

Following these dramatic changes, there is still an urgent need to understand the advantages and characteristics of our current treatment strategies in different settings and populations. Therefore, this Special Issue will highlight all aspects of state-of-the-art therapy, including but not limited to special patient populations, prognostic or predictive markers and real-world application experiences.

We welcome all studies who share our fascination for this topic and help to understand how we can treat patients in the most effective manner possible.

Prof. Dr. Philipp Ivanyi
Dr. Hendrik Eggers
Guest Editors

Manuscript Submission Information

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Keywords

  • renal cell carcinoma
  • treatment
  • metastatic
  • prediction
  • medical treatment
  • immunotherapy
  • multimodal therapy
  • targeted therapy

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Published Papers (1 paper)

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Research

11 pages, 1558 KiB  
Article
Endovascular Downstaging: A New Method for Managing Renal Cell Carcinoma Tumor Thrombus Invading the Inferior Vena Cava Above the Hepatic Veins (Level III) or into the Heart (Level IV)
by John A. Libertino, Malik Ahmed, Thomas Piemonte and Jason Gee
Cancers 2025, 17(2), 264; https://doi.org/10.3390/cancers17020264 - 15 Jan 2025
Viewed by 453
Abstract
Background: Renal cell carcinoma tends to invade venous structures, frequently extending beyond the inferior vena cava and into the heart itself, such as into the right atrium or right ventricle. Resection of tumor burden, particularly tumor thrombus, often requires cardiopulmonary bypass (CPB) and [...] Read more.
Background: Renal cell carcinoma tends to invade venous structures, frequently extending beyond the inferior vena cava and into the heart itself, such as into the right atrium or right ventricle. Resection of tumor burden, particularly tumor thrombus, often requires cardiopulmonary bypass (CPB) and deep hypothermic circulatory arrest (DHCA), which is not feasible for all patients. Methods: Described in this study is a novel, minimally invasive endovascular approach involving endovascular thrombectomy as a viable approach in these select patients. Results: There were no surgical complications, shorter operating times, less blood loss and an average length of stay of 5.5 days in the four patients undergoing this procedure. Conclusions: We demonstrate that this technique can eliminate the need for cardiac bypass and deep hypothermic cardiac arrest and its associated risks, thereby making surgery safer and more accessible for patients with advanced kidney cancers with an inferior vena cava tumor thrombus. Furthermore, it allows for this life-saving surgery to be carried out in medical centers or hospitals where cardiac surgery is unavailable, or when cardiopulmonary bypass is medically contraindicated. Full article
(This article belongs to the Special Issue Advances in Renal Cell Carcinoma)
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