Gastrointestinal and Its Associated Malignancies: Diagnosis, Targets and Therapies
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".
Deadline for manuscript submissions: closed (15 January 2025) | Viewed by 1134
Special Issue Editors
Interests: GI cancers; translational research; cancer therapeutics
Interests: cancer metastasis; anticancer drugs
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Gastrointestinal cancers constitute a heterogenous and aggressive group of malignancies characterized by high relapse rates. They are ranked as the third-leading cause of cancer-related deaths, and this emphasizes the pressing need for advancements in both their diagnosis and treatment strategies. Unfortunately, a significant number of patients face late-stage diagnoses due to the unremarkable nature of early symptoms and the limited prevalence of regular screenings.
Diagnostic procedures include a range of techniques such as endoscopy, barium swallow, CT, NMR, PET/CT scans, and biomarker testing, as well as MRI with gadolinium and laparoscopy. This delayed identification, coupled with the constraints of available therapies, contributes to a grim prognosis, especially for individuals with advanced gastric cancer, resulting in a short lifespan of approximately one year. Standard treatment modalities involve radiotherapy, chemotherapy, and targeted therapy, yet their effectiveness is impeded by challenges like multi-drug resistance and tumor relapse.
Perioperative chemotherapy has emerged as the norm for resectable GI, while ongoing research explores the potential benefits of targeted therapy and immunotherapy across diverse clinical setups. Recent advancements in immunotherapy and biomarker-guided therapies offer optimism for enhanced outcomes, particularly in metastatic cases. The molecular classification of gastric cancer, utilizing biomarkers such as programmed cell death ligand 1 (PD-L1), microsatellite instability (MSI), and human epidermal growth factor receptor 2 (HER2), facilitates tailored treatment approaches. Molecular diagnostics play a pivotal role in characterizing genetic profiles, identifying potential molecular targets, and shaping personalized therapeutic strategies, representing the significant progress made in managing this intricate and challenging group of cancers.
Dr. Ganji P. Nagaraju
Dr. Seema Kumari
Guest Editors
Manuscript Submission Information
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Keywords
- GI cancers
- oncogenesis
- diagnosis
- target identification
- biomarkers
- therapy
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