The Evolving Role of Immunotherapy and Radiotherapy in the Non-operative Management of Esophageal and Rectal Cancer

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: closed (15 October 2023) | Viewed by 3198

Special Issue Editors


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Guest Editor
Department of Radiation Oncology, Mayo Clinic, Rochester, MN 55905, USA
Interests: esophageal cancer; proton radiotherapy; SBRT
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Radiation Oncology, Mayo Clinic, Rochester, MN 55905, USA
Interests: rectal cancer; non-operative management; normal tissue toxicity
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Radiation Oncology, Mayo Clinic, Rochester, MN 55905, USA
Interests: gastrointestinal cancers; DNA damage repair; proton/high-LET particle therapy

Special Issue Information

Dear Colleagues,

This Special Issue welcomes original research that may be preclinical, translational, or clinical regarding radiotherapy or immunotherapy (or preferably both) in the non-operative management of rectal and esophageal cancers. Submissions may also focus on methods of disease surveillance post-therapy, molecular/clinical predictors of response, normal tissue toxicity, and novel treatment strategies to overcome therapeutic resistance. Topics including novel therapeutic agents or interventions for decreasing normal tissue toxicity of either immunotherapy or radiotherapy for esophageal or rectal cancer, as well as predictors of normal tissue toxicity, will also be acceptable. Studies examining the dose, fractionation, and timing of radiotherapy combined with immunotherapy and their differing effects on tumor cell immune evasion, the tumor microenvironment, or pro-inflammatory signaling cascades will also be welcomed. Submissions concerning novel techniques that correlate radiomics and/or pathology with clinical outcomes of radioimmunotherapy in rectal or esophageal cancer are encouraged as well.

We look forward to receiving your contributions.

Dr. Christopher L. Hallemeier
Dr. Krishan R. Jethwa
Dr. Cameron M. Callaghan
Guest Editors

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Keywords

  • radiotherapy
  • immunotherapy
  • non-operative management
  • esophageal cancer
  • rectal cancer

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Published Papers (2 papers)

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Research

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14 pages, 5948 KiB  
Article
ARID1A Deficiency Regulates Anti-Tumor Immune Response in Esophageal Adenocarcinoma
by Le Zhang, Yueyuan Zheng, Wenwen Chien, Benjamin Ziman, Sandrine Billet, H. Phillip Koeffler, De-Chen Lin and Neil A. Bhowmick
Cancers 2023, 15(22), 5377; https://doi.org/10.3390/cancers15225377 - 12 Nov 2023
Viewed by 1687
Abstract
ARID1A, a member of the chromatin remodeling SWI/SNF complex, is frequently lost in many cancer types, including esophageal adenocarcinoma (EAC). Here, we study the impact of ARID1A deficiency on the anti-tumor immune response in EAC. We find that EAC tumors with ARID1A mutations [...] Read more.
ARID1A, a member of the chromatin remodeling SWI/SNF complex, is frequently lost in many cancer types, including esophageal adenocarcinoma (EAC). Here, we study the impact of ARID1A deficiency on the anti-tumor immune response in EAC. We find that EAC tumors with ARID1A mutations are associated with enhanced tumor-infiltrating CD8+ T cell levels. ARID1A-deficient EAC cells exhibit heightened IFN response signaling and promote CD8+ T cell recruitment and cytolytic activity. Moreover, we demonstrate that ARID1A regulates fatty acid metabolism genes in EAC, showing that fatty acid metabolism could also regulate CD8+ T cell recruitment and CD8+ T cell cytolytic activity in EAC cells. These results suggest that ARID1A deficiency shapes both tumor immunity and lipid metabolism in EAC, with significant implications for immune checkpoint blockade therapy in EAC. Full article
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Review

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12 pages, 1175 KiB  
Review
The Evolution of Neo-Adjuvant Therapy in the Treatment of Oesophageal and Gastro-Oesophageal Junction Adenocarcinomas
by Alexander A. Dermanis, Sivesh K. Kamarajah and Benjamin Tan
Cancers 2023, 15(19), 4741; https://doi.org/10.3390/cancers15194741 - 27 Sep 2023
Cited by 1 | Viewed by 1166
Abstract
Historically, oesophageal and gastro-oesophageal junction adenocarcinomas were associated with a poor prognosis. The advent of neoadjuvant therapy has transformed the management of oesophageal and gastro-oesophageal junction adenocarcinomas further and offers the possibility to reverse disease progression, eliminate micrometastasis, and offer potentially better outcomes [...] Read more.
Historically, oesophageal and gastro-oesophageal junction adenocarcinomas were associated with a poor prognosis. The advent of neoadjuvant therapy has transformed the management of oesophageal and gastro-oesophageal junction adenocarcinomas further and offers the possibility to reverse disease progression, eliminate micrometastasis, and offer potentially better outcomes for these patients. This review provides an overview of landmark clinical trials in this area, with different treatment regimens considered over the years as well as potential therapeutic agents on the horizon that may transform the management of oesophageal and gastro-oesophageal junction adenocarcinomas further. Full article
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