Breast Development and Cancer (Volume II)
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Causes, Screening and Diagnosis".
Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 4113
Special Issue Editors
Interests: breast cancer; oncologic breast surgery; post surgery persistent pain syndrome side effects of anticancer treatments; hypnosis sedation; breast cancer recurrence; genomics; inflammation and cancer; fertility preservation and breast cancer; endocrine therapy and breast cancer; mechanismes of endocrine resistance; in situ ductal carcinoma; breast cancer progression; integrative oncology
Special Issues, Collections and Topics in MDPI journals
Interests: breast carcinoma; invasive; ductal; lobular; spécial types; in situ; papillar; stroma; cytology; biopsy; resection specimen; decalcification; immunohistochemistry; receptor; ER; PR; Ki67; HER2; digital pathology; molecular analysis; mutation; fusion genes
Special Issue Information
Dear Colleagues,
This Special Issue is the second edition of a previous one, entitled “Breast Development and Cancer”.
Breast development is a complex process: breasts undergo multiple changes throughout life, from the intrauterine life to senescence. The human breast consists of parenchymal and stromal elements. The parenchyme forms a system of branching ducts eventually leading to secretory acini development, and the stroma consists mainly of adipose tissue, providing the environment for the development of parenchyma; mutual and reciprocal interactions between epithelial components and mesenchymal or stromal cells are responsible for prenatal, infant and pubertal breast development. Evidence suggests that the mesenchyme has indictive properties that lead to the local migration and changes in the cell adhesion of epithelial cells. Hormonal influences on this paracrine interaction between the mesenchyme and parenchyme are evident at all stages of development. The formation of lactiferous ducts is induced by placental hormones entering the foetal circulation; other implicated hormones include progesterone, growth hormone, insulin-like growth factor, oestrogens, prolactin, adrenal corticoids and triidothyronine.
Mammary stem cells and progenitors do not express receptors for hormones, and hormone-positive cells generally do not proliferate.
The microenvironment plays an important role in tissue homeostasis, cancer progression and metastasis.
To fully understand the defects leading to breast cancer, it is essential to decipher the mechanisms that regulate normal mammary development and morphogenesis.
Despite the considerable advancements made in the field, our understanding of the complex cascade of signals between neighbouring cells of developing tissues and the role of the matrix microenvironment is still largely lacking.
Moreover, the same general processes, from proliferation to invasion, that take place during normal mammary development, also occur in malignant disease.
The identification of mechanisms and genes that govern stem and progenitor cell expansion, or that determine daughter cell fate will be of crucial interest for understanding breast cancer diversity and ultimately improving treatment options.
Prof. Dr. Martine Berliere
Prof. Dr. Christine Galant
Guest Editors
Manuscript Submission Information
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Keywords
- breast development
- breast cancer
- interactions between stroma and epithelial cells
- hormone receptors
- stem cells
- progenitors
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