Non-coding RNA and Cancer
A special issue of Cancers (ISSN 2072-6694).
Deadline for manuscript submissions: closed (28 February 2013) | Viewed by 10860
Special Issue Editor
Special Issue Information
Dear Colleagues,
A major challenge in our current understanding of gene expression is the finding that most of the genome is being transcribed. This results in the production of not only mRNAs with protein coding potential but also in a variety of non-coding RNA molecules. One school of thought argues that non-coding RNAs represent errors of the transcriptional apparatus, while others highlight that these molecules may have functional, but sometimes difficult to experimentally define, biological roles. In line with the latter view, evidence is accumulating for the impact of non-coding RNAs in gene transcription, translation, RNA stability, pre-mRNA splicing and chromatin structure. This special issue welcomes manuscripts that address the functional implications of short and long non-coding RNAs, with emphasis on their involvement in disease states and more specifically cancer development.
Prof. Dr. Peter Zaphiropoulos
Guest Editor
Manuscript Submission Information
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Keywords
- gene transcription
- RNA polymerase
- micro RNA
- long non-coding RNA
- cell proliferation
- tumor growth
- metastasis
- oncogene
- tumor suppressor gene
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