Research in Personalized Cancer Vaccine
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Immunology and Immunotherapy".
Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 7461
Special Issue Editors
Interests: cancer immunotherapy; vaccines; treg cells; adoptive cell therapy; immunomodulation
Special Issue Information
Dear Colleagues,
Modulation of the immune system is revolutionizing the fight against cancer. Although most patients have an immune response specific for their cancer, cancerous cells find ways to evade immunosurveillance. Existing immunotherapies, such as the immunocheckpoint blockers that aim to reactivate that immune response, have shown positive effects in a significant proportion of patients. Unfortunately, in the majority of cases, these immunomodulatory strategies are not curative and other ways to prime and/or boost the antitumor response are urgently needed. The idea of treating cancers by using vaccines has been around for many years. In this scenario, the identification of key tumor-associated antigens for vaccine development has been intensively pursued. However, tumor-associated antigen vaccines have not offered exciting results in most of the clinical trials carried out, probably because of the immunotolerance against self-antigens, the poor immunogenicity of vaccine formulations, or the presence of a highly immunosuppressive tumor microenvironment. The incredible progress in Next Generation Sequencing techniques has made it possible to decipher complex mixtures of RNA and DNA samples and to identify the differences that make each patient’s tumor unique. This knowledge is being applied in the identification of new tumor antigens for the design and manufacture of personalized cancer vaccines. In addition to their identification as potential rejection antigens, studies on vaccine formulation, delivery systems, adjuvants and immunomodulators are needed to prepare efficient vaccines than can be administered to patients in a timely manner. Harnessing the immune system’s natural ability to find and kill cancer cells is the best way to treat cancer in the long term.
This Special Issue will highlight the current state of the art of all these relevant aspects for the design of personalized cancer vaccines and the future prospects for improving their efficacy.
Prof. Dr. Juan José Lasarte
Prof. Dr. Pablo Sarobe
Guest Editors
Manuscript Submission Information
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Keywords
- neoantigens
- tumor associated antigens
- adjuvants
- immunomodulation
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