The Role of Genes in Prostate Cancer

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Tumor Microenvironment".

Deadline for manuscript submissions: 25 December 2024 | Viewed by 1093

Special Issue Editor


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Guest Editor
Nuffield Department of Surgical Sciences, University of Oxford, Level 6, Room 6600, John Radcliffe Hospital, Headley Way, Headington, Oxford OX3 9DU, UK
Interests: prostate cancer; genetics; genomics; immunity; microenvironment; DNA repair

Special Issue Information

Dear Colleagues,

We are delighted to introduce this Special Issue of Cancers on the role of genes in prostate cancer. Prostate cancer is the fifth leading cause of cancer death in men worldwide, with an estimated 1.4 million cases of prostate cancer diagnosed, and an estimated 375,000 men have died from prostate cancer. Prostate cancer is a clinical and molecular heterogeneous disease with disparities in incidence and mortality. This Special Issue will highlight new genetic and genomic insights into prostate cancers, which have provided a better comprehensive landscape of the germline variations or somatic molecular profiles involved in prostate cancer carcinogenesis or in the progression to metastatic and lethal disease.

Prof. Dr. Olivier Cussenot
Guest Editor

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Keywords

  • prostate cancer
  • genes
  • microenvironment

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Published Papers (1 paper)

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Review

21 pages, 2488 KiB  
Review
Deciphering the Tumor Microenvironment in Prostate Cancer: A Focus on the Stromal Component
by Hubert Pakula, Filippo Pederzoli, Giuseppe Nicolò Fanelli, Pier Vitale Nuzzo, Silvia Rodrigues and Massimo Loda
Cancers 2024, 16(21), 3685; https://doi.org/10.3390/cancers16213685 - 31 Oct 2024
Viewed by 755
Abstract
Prostate cancer progression is significantly affected by its tumor microenvironment, in which mesenchymal cells play a crucial role. Stromal cells are modified by cancer mutations, response to androgens, and lineage plasticity, and in turn, engage with epithelial tumor cells via a complex array [...] Read more.
Prostate cancer progression is significantly affected by its tumor microenvironment, in which mesenchymal cells play a crucial role. Stromal cells are modified by cancer mutations, response to androgens, and lineage plasticity, and in turn, engage with epithelial tumor cells via a complex array of signaling pathways and ligand–receptor interactions, ultimately affecting tumor growth, immune interaction, and response to therapy. The metabolic rewiring and interplay in the microenvironment play an additional role in affecting the growth and progression of prostate cancer. Finally, therapeutic strategies and novel clinical trials with agents that target the stromal microenvironment or disrupt the interaction between cellular compartments are described. This review underscores cancer-associated fibroblasts as essential contributors to prostate cancer biology, emphasizing their potential as prognostic indicators and therapeutic targets. Full article
(This article belongs to the Special Issue The Role of Genes in Prostate Cancer)
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