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Cancers
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Recent Advances in Orthopaedic Oncology: 2nd Edition
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Recent Advances in Orthopaedic Oncology: 2nd Edition

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 28 February 2025 | Viewed by 1355

Special Issue Editor

Dr. Tomoki Nakamura

E-Mail Website
Guest Editor
Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, Tsu 514-8570, Japan
Interests: orthopedic oncology; soft tissue sarcoma; bone sarcoma; metastasis; limb salvage surgery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Bone and soft tissue sarcomas are infrequent and heterogenous tumours that account for 1% of all cancers. Distant metastasis is relatively common in high-grade tumours, and many basic studies are focusing on developing new systemic therapies for improving survival. Clinical research elucidates oncologic and functional outcomes after the local and systemic treatment of tumours.

Orthopaedic oncology also includes benign tumours. Certain benign tumours, such as giant cell tumours, solitary bone tumours, and desmoid tumours, are often problematic and require discussion.

We are pleased to invite you to submit your work to this Special Issue on “Recent Advances in Orthopaedic Oncology”. This Special Issue aims to clinically investigate new diagnostic and therapeutic techniques. We will also investigate possible applications for future treatment in basic studies.

For this Special Issue, we welcome original research articles and reviews. Research areas may include (but are not limited to) the following: bone sarcomas, soft tissue sarcomas, and benign bone and soft tissue tumours.

I look forward to receiving your contributions.

Dr. Tomoki Nakamura
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bone and soft tissue sarcomas
  • orthopaedic oncology
  • benign tumours
  • giant cell tumours
  • solitary bone tumours
  • desmoid tumours

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Related Special Issue

Published Papers (2 papers)

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Research

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7 pages, 1771 KiB  
Article
Differences in Outcomes Based on the Degree to Which Bone Defects Are Filled with Cancellous Allochip Bone Grafts in Hand Enchondroma Patients
by Sung Ju Kang, Jun-Hyuk Lim, Chan Wi Kim, Gyo Rim Kang, Sungmin Kim and Sung-Taek Jung
Cancers 2024, 16(22), 3811; https://doi.org/10.3390/cancers16223811 - 13 Nov 2024
Viewed by 348
Abstract
Background/Objectives: Enchondroma, the most common benign cartilage tumor in the hand, often presents as pain, swelling, or pathological fractures. While curettage is the standard treatment preventing fractures, the optimal way of managing the bone cavity remains debated. In this study, we investigated the [...] Read more.
Background/Objectives: Enchondroma, the most common benign cartilage tumor in the hand, often presents as pain, swelling, or pathological fractures. While curettage is the standard treatment preventing fractures, the optimal way of managing the bone cavity remains debated. In this study, we investigated the impact of a filled bone defect on radiologic and clinical outcomes among patients with enchondroma. Methods: We retrospectively reviewed patients with solitary enchondroma of the hand who underwent curettage followed by allogeneic cancellous bone chip impaction grafting. The patients were divided into two groups based on the extent to which their bone defects were filled post-curettage: Group 1 (complete filling) and Group 2 (incomplete filling, i.e., <50%). We reviewed demographic data, local recurrence data, complications, information on consolidation duration, data on range of motion (ROM), and functional scores. Results: This study included 59 patients (25 males and 34 females; mean age, 30.4 ± 11.9 years, with a range of 8–78). Group 1 contained 35 patients, and Group 2 contained 24. No nonunion occurred following curettage and grafting. The mean radiological consolidation period was 6.4 weeks (range: 5–18). There was no significant difference in consolidation time between Group 1 (6.8 weeks) and Group 2 (6.9 weeks) (p = 0.166). The ROM and functional scores also showed no significant differences between the groups, with musculoskeletal society scores of 98.8 for Group 1 and 99.8 for Group 2 (p = 0.63). Conclusions: This study demonstrates that the use of the impaction technique combined with cancellous allochip bone grafting yields favorable results in the treatment of solitary hand enchondroma. The extent to which the bone defect was filled did not significantly impact the overall outcomes. Full article
(This article belongs to the Special Issue Recent Advances in Orthopaedic Oncology: 2nd Edition)
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Review

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12 pages, 274 KiB  
Review
Atypical Spindle Cell/Pleomorphic Lipomatous Tumor: A Review and Update
by Jun Nishio, Shizuhide Nakayama, Yoshiro Chijiiwa, Mikiro Koga and Mikiko Aoki
Cancers 2024, 16(18), 3146; https://doi.org/10.3390/cancers16183146 - 13 Sep 2024
Viewed by 779
Abstract
Atypical spindle cell/pleomorphic lipomatous tumor (ASCPLT) is a rare and recently described adipocytic neoplasm that primarily occurs in the subcutis of the limbs and limb girdles, particularly of middle-aged adults. It has locally recurrent potential if incompletely excised but no risk for distant [...] Read more.
Atypical spindle cell/pleomorphic lipomatous tumor (ASCPLT) is a rare and recently described adipocytic neoplasm that primarily occurs in the subcutis of the limbs and limb girdles, particularly of middle-aged adults. It has locally recurrent potential if incompletely excised but no risk for distant metastasis. ASCPLT is histologically similar to spindle cell/pleomorphic lipoma and atypical lipomatous tumor and shows a mixture of atypical spindle cells, adipocytes, lipoblasts, floret-like multinucleated giant cells, and/or pleomorphic cells. It has been recently recognized that ASCPLT can undergo sarcomatous transformation. However, the biological significance of morphological sarcomatous transformation in ASCPLT remains uncertain. Immunohistochemically, the tumor cells show variable expression of CD34, S-100 protein, and desmin. Loss of nuclear Rb expression is observed in the majority of cases. ASCPLT lacks MDM2 gene amplification but can show RB1 gene deletion in a significant subset of cases. Complete surgical excision is the treatment of choice. This review provides an overview of the current knowledge on the clinicoradiological features, pathogenesis, histopathology, and treatment of ASCPLT. In addition, we will discuss the differential diagnosis of this new entity. Full article
(This article belongs to the Special Issue Recent Advances in Orthopaedic Oncology: 2nd Edition)
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