Role of Platelet-Derived Extracellular Vesicles in Cancer and Metastasis
A special issue of Cancers (ISSN 2072-6694).
Deadline for manuscript submissions: closed (10 July 2023) | Viewed by 3859
Special Issue Editors
Interests: platelets; colorectal cancer; metastasis; antiplatelet drugs; aspirin; P2Y12 antagonists; eicosanoids; extracellular vesicles; nonsteroidal anti-inflammatory agents (NSAIDs); lipidomics; lipidomics for biomarker development
Special Issues, Collections and Topics in MDPI journals
Interests: vascular biology; pharmacology of nonsteroidal anti-inflammatory drugs; system pharmacology; genomics; metabolomics; microbiome; RNA-sequencing; atherosclerosis; heart failure; myocardial infarction; thrombosis; platelet aggregation; NSAID-induced enteropathy; aspirin and cancer
Special Issue Information
Dear Colleagues,
Platelets contribute to several types of cancer through many mechanisms. Platelets contain a changing repertoire of proteins and genetic material, including transcripts and microRNAs (i.e., small noncoding RNAs) that act as regulators of gene expression by post-transcriptional mechanisms. Upon platelet activation, biologically active molecules are secreted in a soluble form or packaged into extracellular vesicles (EVs). EVs have the peculiarity of interacting with cancer cells to transfer their molecular cargo. Moreover, EVs can activate other cells, including vascular and immune cells and fibroblasts. Hence, platelets are a crucial component of cell–cell communication, promoting tumorigenesis. In particular, their interaction with cancer cells can enhance their malignancy and facilitate the invasion and colonization of distant organs. These findings suggest the use of antiplatelet agents to restrain cancer development and progression. Another peculiarity of platelets is their ability to uptake proteins and transcripts from the circulation. Thus, cancer-patient platelets and platelet-derived EVs show specific proteomic and transcriptomic expression patterns, a phenomenon called tumor-educated platelets (TEPs). The transcriptomic/proteomic profile of platelets and EVs can provide early cancer detection and disease monitoring information.
This topic aims to highlight the latest advances in novel functions of EVs in cancer and metastasis development. Moreover, studies on the development of novel biomarkers based on the analysis of platelets and EVs for the early detection of cancer, as well as those on monitoring the disease and therapeutic efficacy, are of interest. Original research papers and review articles are welcomed.
We look forward to receiving your contributions.
Prof. Dr. Paola Patrignani
Dr. Emanuela Ricciotti
Dr. Annalisa Contursi
Guest Editors
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Keywords
- extracellular vesicles
- EVs
- cancer
- metastasis
- platelets
- antiplatelet drugs
- lipidomics
- platelet-derived microparticles
- nonsteroidal anti-inflammatory agents (NSAIDs)
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