Biocatalysis-Biotransformations in Organic Synthesis

A special issue of Catalysts (ISSN 2073-4344). This special issue belongs to the section "Biocatalysis".

Deadline for manuscript submissions: closed (31 December 2020) | Viewed by 2942

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Guest Editor
Department of Chemistry, University of Crete, Campus Voutes-Heraklion, 71003 Crete, Greece
Interests: biocatalysis; asymmetric synthesis of high-value compounds using biocatalytic methods; applied Biocatalysis; redox enzymes and their applications towards the synthesis of useful chiral intermediates; green chemistry
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Special Issue Information

Dear Colleagues,

Biocatalysis has long been known as a green technology, capable of delivering highly stereo-, chemo-, and regioselective transformations that can sometimes allow the number of steps in a synthetic route to be reduced. The contributions of biocatalysis and biotransformations in organic synthesis are of increasing importance and reflect the emerging challenge for the academic community and the chemical industry as they move towards green and sustainable chemistry. The modern demands for environmentally friendly processes during the production of useful compounds are satisfied by the application of biocatalytic transformations on the most important reaction steps of the synthetic protocol. Biotransformations offer a great opportunity for their applications in cascade one-pot processes.

This Special Issue on “Biocatalysis and Biotransformations in Organic Synthesis” will offer an attractive forum to present recent advances in biocatalysis research, from development of biocatalysts and enzyme discovery to enzyme immobilization, development of new (chemo)enzymatic cascades, and novel classes of artificial enzymes and their applications in organic synthesis. I strongly encourage authors to submit papers for this Special Issue on “Biocatalysis and Biotransformations in Organic Synthesis”, within the scope of Catalysts.

Dr. Ioulia Smonou
Guest Editor

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Keywords

  • Biocatalysis
  • Enzymatic reactions
  • Biotransformations
  • Multistep enzymatic transformations
  • Chemoenzymatic synthesis
  • Synthetic bioorganic chemistry
  • Sustainable chemistry
  • Novel biocatalytic processes
  • Immobilized biocatalysts.

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Published Papers (1 paper)

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Research

9 pages, 819 KiB  
Article
Highly Regioselective and Stereoselective Biohydroxylations of Oxandrolone
by Paulina Łyczko, Anna Panek and Alina Świzdor
Catalysts 2021, 11(1), 16; https://doi.org/10.3390/catal11010016 - 25 Dec 2020
Viewed by 2454
Abstract
Microbially catalyzed reactions are a powerful and valuable tool for organic synthesis of many compounds with potential biological activity. Herein, we report efficient hydroxylations of the steroidal anabolic-androgenic lactone, oxandrolone, in the cultures of three strains of fungi, Fusarium culmorum, Mortierella isabellina [...] Read more.
Microbially catalyzed reactions are a powerful and valuable tool for organic synthesis of many compounds with potential biological activity. Herein, we report efficient hydroxylations of the steroidal anabolic-androgenic lactone, oxandrolone, in the cultures of three strains of fungi, Fusarium culmorum, Mortierella isabellina, and Laetiporus sulphureus. These reactions resulted in the production of four metabolites identified as 12β-hydroxyoxandrolone (2), 9α-hydroxyoxandrolone (3), 6α-hydroxyoxandrolone (4), and 15α-hydroxyoxandrolone (5), the latter being a new compound. The high substrate conversion rates and the product yields achieved indicate that these strains offer a new way to generate steroidal hydroxylactones with potential pharmaceutical interest. The structures of the isolated derivatives were characterized on the basis of spectroscopic data. The effect of modification of the A-ring structure of the steroid by the lactone group on the selectivity of hydroxylation in cultures of the tested fungi is also discussed. Full article
(This article belongs to the Special Issue Biocatalysis-Biotransformations in Organic Synthesis)
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