Lipids, Lipoproteins and Lipid-Targeting Therapies in the Regulation of Immune Function and Inflammation

Dear Colleagues,

Lipid-related pathways are known to play a critical role in the regulation of immune cell activity. Endogenous and exogenous (e.g., dietary) lipids can regulate leukocyte activation, differentiation, and inflammatory potential, with important implications for the pathophysiology of chronic inflammatory and cardiometabolic diseases, as well as defense against pathogens. Recent evidence further suggests that lipoproteins play an important role in regulating immune outcomes—including growing research highlighting the protective role of high-density lipoproteins (HDLs) in infectious diseases such as sepsis and COVID-19, and their capacity to carry over 250 proteins—and many have immunomodulatory properties. Moreover, pharmaceutical and lifestyle intervention-based therapies that target lipid metabolism or lipoprotein profiles show promise in the management of conditions characterized by immune dysfunction. This Special Issue invites authors to submit reviews and research articles that present new knowledge on the mechanisms by which lipids, lipoproteins, and lipid-targeting therapies modulate immune function and inflammation, in addition to advances in the methodologies and technological approaches to characterizing lipid–immune pathways. Topics may include, but are not limited to, the immunomodulatory effects of endogenous and exogenous lipids; the immunomodulatory properties of lipoproteins; HDL proteomics and lipidomics; the immunomodulatory and anti-inflammatory effects of lipid-targeting therapies (e.g., statins, LXR agonists, fibrates); the immunomodulatory and anti-inflammatory effects of lifestyle interventions (e.g., diet, exercise) that target lipid metabolism and cardiometabolic health; lipid and immune pathways in chronic inflammatory and cardiometabolic diseases; lipid and immune pathways in infectious disease; lipid and immune pathways in conditions of immune dysfunction (e.g., autoimmunity, allergy); and advances in methods and technologies for characterizing lipid–immune pathways and their application.

Dr. Catherine J. Andersen
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• lipids
• lipoproteins
• HDL
• lipid-targeting therapies
• immune function
• immune cell activation and differentiation
• immune inflammation
• chronic disease
• cardiometabolic disease
• infectious disease
• proteomics
• lipidomics
• lifestyle interventions
• emerging methods