Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue polices and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Roles and Mechanisms of Ubiquitin Ligases (E3) and Deubiquitinases (DUBs)
edited by , Tsunehiro Mizushima and Hideki Yashiroda
submission deadline 31 Jan 2025 | 10 articles | Viewed by 19728
Keywords: E3 ubiquitin ligases; deubiquitinases; ubiquitin; ubiquitination; proteasome
(This special issue belongs to the Section Cell Signaling)
The Emerging Role of Astrocytes in Health and Neurological Diseases
edited by
submission deadline 31 Jan 2025 | 7 articles | Viewed by 16727
Keywords: astrocyte network; gliotransmitters; astrocytes in learning and memory; astrocytes and the blood– brain barrier; astrocyte pathologies
(This special issue belongs to the Section Cells of the Nervous System)
Advanced Technology for Cellular Imaging
edited by Alessandro Grinzato, and
submission deadline 31 Jan 2025 | 7 articles | Viewed by 13396
Keywords: electron tomography; fluorescence microscopy; live cell imaging; multimodal imaging; super resolution microscopy; cell– cell interaction
(This special issue belongs to the Section Cell Methods)
Organ and Tissue Fibrosis: Molecular Signals and Cellular Mechanisms
edited by
submission deadline 31 Jan 2025 | 6 articles | Viewed by 13137
Keywords: fibrosis; scarring; cytokine; myofibroblasts; extracellular matrix; growth factors; mesenchymal transition
(This special issue belongs to the Section Tissues and Organs)
Molecular Mechanisms of Cell Division and Chromosome Segregation: What Can Go Wrong? submission deadline 31 Jan 2025 | 5 articles | Viewed by 11397
Keywords: mitosis; cell division; genetic instability; aneuploidy; lagging chromosomes; chrosomomes misalignment; mitotic checkpoint; microtubules attachment; kinetochores; microtubules dynamics
(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)
Microenvironmental Factors and Functional Modulation in Mesenchymal Stem Cells 2.0 submission deadline 31 Jan 2025 | 5 articles | Viewed by 9181
Keywords: mesenchymal stem cells; inflammation; microenvironment; regeneration of mesenchymal stem cell receptors; stem cell differentiation
(This special issue belongs to the Section Stem Cells)
Molecular and Cellular Mechanisms of Cardiovascular and Metabolic Diseases
edited by
submission deadline 31 Jan 2025 | 4 articles | Viewed by 8623
Keywords: mitochondrial dysfunction; endoplasmic reticulum (ER) stress; oxidative/nitrosative stress; diabetes; obesity; diet; atherosclerosis; hypertension; metabolomics; cell death; nutraceuticals/functional foods
(This special issue belongs to the Section Cells of the Cardiovascular System)
Mitochondria and Other Organelles in Neurodegenerative Diseases
edited by Tian Liu
submission deadline 31 Jan 2025 | 3 articles | Viewed by 5139
Keywords: mitochondria dysfunction; ER stress; TDP-43 pathology; protein aggregation; tauopathy; neuroinflammation; neurodegeneration; neurodegenerative diseases; therapeutic approaches
(This special issue belongs to the Section Intracellular and Plasma Membranes)
Cellular Mechanisms in Autoimmune Encephalitis: Biology and Potential Therapeutic Implications
edited by and Dominique Fernandes
submission deadline 31 Jan 2025 | 1 articles | Viewed by 4641
Keywords: neuroimmunology; pathogenesis; diagnosis; neuroimmune disorders; autoimmune encephalitis
(This special issue belongs to the Section Cells of the Nervous System)
Demystifying the Role of the Immune System in Modulating Pathogenic Fibrosis
edited by Gerlinde Wernig and
submission deadline 31 Jan 2025 | 1 articles | Viewed by 2433
Keywords: unifying fibrotic mechanisms; genetic markers of disease; innate immunity; drug discovery
(This special issue belongs to the Section Cellular Pathology)
Cilia-Based New Discoveries: Ciliogenesis, Function, and Human Diseases submission deadline 31 Jan 2025 | 2 articles | Viewed by 2025
Keywords: primary cilium; human disease; cell signaling; mTOR; Hedgehog; WNT; PDGFRalpha
New Targets and Therapeutic Approaches Based on Molecular Mechanisms in Tumorigenesis and Cancer Metastasis
edited by
submission deadline 31 Jan 2025 | 2 articles | Viewed by 1642
Keywords: metastasis; cancer; therapy; precision medicine; cancer stem cells; immuno-oncology; tumor microenvironment; antibody
(This special issue belongs to the Section Cell Microenvironment)
Cellular and Molecular Events in Intervertebral Disc Development, Homeostasis and Disease
edited by
submission deadline 31 Jan 2025 | 1 articles | Viewed by 1622
Keywords: disc development; healthy intervertebral disc; IVD
Ion Channel Involvement in Neurological and Neuromuscular Disorders submission deadline 31 Jan 2025 | 1 articles | Viewed by 1558
Keywords: ion channels; neurological diseases; neuromuscular diseases; personalized therapy
(This special issue belongs to the Section Cells of the Nervous System)
Impact of Platelet Defects on Pathophysiological Processes II submission deadline 31 Jan 2025 | Viewed by 309
Keywords: platelet physiology; platelet pathophysiology; inherited platelet defects; signaling; bleeding; sepsis; acquired platelet disorder; developmental pathogenesis
(This special issue belongs to the Section Cellular Pathology)
The Interplay between the Immune and Central Nervous Systems in Health and Disease: Current Insights and Future Directions
edited by
submission deadline 31 Jan 2025 | Viewed by 304
Keywords: astrocytes; immunotherapy; inflammatory response; innate and adaptive immunity; microglia; neuroinflammation; neurological diseases; psychiatric disorders; therapeutic avenues
(This special issue belongs to the Section Cellular Immunology)
The Diverse Roles of DNA Methylation and Hydroxymethylation in Embryonic Development
edited by
submission deadline 31 Jan 2025 | Viewed by 253
Keywords: DNA methylation; DNA hydroxymethylation; mouse embryonic development; human embryonic development; Tet; Dnmt
Regulation of Cell Division
edited by Katie Shannon
submission deadline 31 Jan 2025 | Viewed by 242
Keywords: mitosis; kinetochore; chromosome segregation; actomyosin ring; cytokinesis; septation; mitotic exit network; spindle assembly checkpoint
(This special issue belongs to the Section Cell Proliferation and Division)
Regulatory T Cells and Autoimmunity
edited by Fan Pan
submission deadline 10 Feb 2025 | 2 articles | Viewed by 4986 | Submission Open
Keywords: regulatory T cells; immune tolerance; Foxp3; autoimmune disease (AD); immunotherapy
(This special issue belongs to the Section Cellular Immunology)
Novel Biomarkers in Eye Diseases
edited by
submission deadline 10 Feb 2025 | Viewed by 153 | Submission Open
Keywords: biomarkers; tears; ocular surface; retina; ocular fluids; inflammation; neuromodulation; parainflammation; omics; lab-on-chip
(This special issue belongs to the Section Cellular Pathology)
Novel Insights into Molecular Mechanisms and Therapy of Asthma
edited by
submission deadline 15 Feb 2025 | 5 articles | Viewed by 19843 | Submission Open
(This special issue belongs to the Section Cellular Pathology)
Stem Cell, Differentiation, Regeneration and Diseases
edited by , Guoqiang Sun and
submission deadline 15 Feb 2025 | 9 articles | Viewed by 18711 | Submission Open
Keywords: stem cell; development; differentiation; tissue regeneration; organoid; disease modeling; stem cell therapy; cancer
(This special issue belongs to the Section Stem Cells)
Drosophila Models in Autophagy and Aging
edited by , and Panagiotis D. Velentzas
submission deadline 15 Feb 2025 | 3 articles | Viewed by 6461 | Submission Open
Keywords: autophagy; apoptosis; brain– gut axis; brainopathies; development; Drosophila model of human diseases; microbiome; mitophagy; necrosis; neurodegenerative diseases; proteostasis; signaling; ubiquitin– proteasome system
(This special issue belongs to the Section Autophagy)
Research on Proteomics and Its Applications in Disease
edited by
submission deadline 15 Feb 2025 | 1 articles | Viewed by 2464 | Submission Open
Keywords: bottom-up proteomics; top-down proteomics; spatial proteomics; bioinformatics; human diseases; cancer; viral infections; bacterial infections; rare pathologies
(This special issue belongs to the Section Cell Methods)
Large-Scale Multi-Omic Approaches and Atlas-Based Profiling for Cellular, Molecular, and Functional Specificity, Heterogeneity, and Diversity in the Endocannabinoid System
edited by and
submission deadline 15 Feb 2025 | 1 articles | Viewed by 1695 | Submission Open
Keywords: lipidomics; proteomics; transcriptomics; cluster analysis; massive parallel screening; molecular markers; brain circuits; development; neural plasticity; synapse; appetite and feeding behavior; addiction; pain; epilepsy; neurological disorders
(This special issue belongs to the Section Cells of the Nervous System)
Epigenetic Mechanisms of Tumorigenesis
edited by
submission deadline 15 Feb 2025 | Viewed by 233 | Submission Open
Keywords: epigenetics; tumorigenesis; gene expression; cell identity; precise medicine
Mechanism of Cell Signaling during Eye Development and Diseases submission deadline 20 Feb 2025 | 15 articles | Viewed by 25104 | Submission Open
Keywords: cell signaling; ocular; eye disorders; Wnt signaling; TGF-β
(This special issue belongs to the Section Cell Signaling)
Unlocking the Secrets Behind Drug Resistance at the Cellular Level submission deadline 20 Feb 2025 | 2 articles | Viewed by 4860 | Submission Open
Keywords: molecular mechanisms; effective treatments; drug tests; bacterial resistance; chemoresistance
(This special issue belongs to the Section Cellular Immunology)
Advances in DNA Repair Disorders Research: Molecular Mechanisms, Novel Therapies and Implications for Understanding Aging, Neurological Dysfunction and Cancer Progression
edited by Manuela Lanzafame
submission deadline 20 Feb 2025 | 2 articles | Viewed by 3247 | Submission Open
Keywords: DNA repair diseases; molecular mechanism; signaling pathway; therapies; aging; cancer; neurological dysfunction
(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)
Control of Gene Expression by Co-transcriptional Processes in Cell Homeostasis and Cell Fate Specification: Second Edition
edited by
submission deadline 20 Feb 2025 | 1 articles | Viewed by 1561 | Submission Open
Keywords: gene transcription; transcription elongation; RNA processing; RNA modification; RNA transport; lncRNA; histone modification; biomolecular condensates; diseases associated with dysregulation of gene regulation
(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)
Cell Therapeutics for Corneal Diseases submission deadline 20 Feb 2025 | 1 articles | Viewed by 1310 | Submission Open
Keywords: cell therapies; corneal diseases; drug development; tissue engineering; stem cells; regeneration; tissue repair
Signaling Pathways Involved in Tumor Microenvironment and Tumor Adaptation to Stresses
edited by Nianli Sang
submission deadline 20 Feb 2025 | 1 articles | Viewed by 744 | Submission Open
Keywords: microenvironment; metabolic stress; hypoxia; chemoresistance; radiation resistance; apoptosis; metabolic reprogramming; metastasis
Gene and Cellular Signaling Related to Muscle
edited by
submission deadline 20 Feb 2025 | Viewed by 276 | Submission Open
Keywords: skeletal muscle; molecular mechanism; muscle atrophy; therapeutics; metabolic signals; satellite cells
Advances in Immunotherapy for Non-Small-Cell Lung Cancer
edited by
submission deadline 20 Feb 2025 | Viewed by 185 | Submission Open
Keywords: non-small cell lung cancer; immunotherapy; immune checkpoint inhibitors; PD-1; PD-L1; pembrolizumab; nivolumab; atezolizumab; CTLA4
(This special issue belongs to the Section Cellular Immunology)
Natural Killer Cells in Cancer Immunotherapy: Molecular Mechanisms, Diagnostic and Therapeutic Opportunities
edited by
submission deadline 20 Feb 2025 | Viewed by 169 | Submission Open
Keywords: natural killer cells; immunotherapy; solid tumors; tumor suppression; immunomodulation; clinical practice
(This special issue belongs to the Section Cellular Immunology)
Pluripotent Stem Cells: Current Applications and Future Directions
edited by
submission deadline 25 Feb 2025 | 3 articles | Viewed by 8103 | Submission Open
Keywords: induced pluripotent stem cells; organoids; reprogramming; differentiation; spheroids; cortical organoids; intestinal organoids; kidney organoids; cardiomyocytes; astrocytes; microglia; personalized medicine; drug screening; disease modeling
(This special issue belongs to the Section Stem Cells)
Cancer-Associated Fibroblasts: Challenges and Directions submission deadline 25 Feb 2025 | 4 articles | Viewed by 7654 | Submission Open
Keywords: cancer-associated fibroblast (CAFs); tumor microenvironment (TME); fibroblast activation protein alpha (FAPα ); immunotherapy; cytokines; angiogenesis; metastasis; FAP inhibitors; radioligands; imaging agents
(This special issue belongs to the Section Cell Microenvironment)
Protein Misfolding Diseases: From Experimental Approaches to Therapeutic Opportunities submission deadline 25 Feb 2025 | 2 articles | Viewed by 5698 | Submission Open
Keywords: protein aggregation; amyloid; neurodegenerative diseases; cancer; diabetes
(This special issue belongs to the Section Cellular Pathology)
Advances and Breakthroughs in Stem Cell Research submission deadline 25 Feb 2025 | 2 articles | Viewed by 5169 | Submission Open
Keywords: stem cell; induced pluripotent stem cell; iPSC; hematopoietic stem cell
(This special issue belongs to the Section Stem Cells)
Microproteins: From Identification to the Discovery of Their Functions
edited by
submission deadline 25 Feb 2025 | 3 articles | Viewed by 3505 | Submission Open
Keywords: microproteins; short open reading frame-encoded peptides (SEPs); alternative proteins; functional characterization; mass spectrometry; transcriptomics; ribosome profiling; functional genomics; molecular mechanisms; cellular processes; signaling pathways; cellular homeostasis; protein– protein interactions
Emerging Insights into Natural Killer Cell Immunity in Infection and Cancer
edited by Sumit Sen Santara, , Weshely Kujur and Sachin Mulik
submission deadline 25 Feb 2025 | Viewed by 447 | Submission Open
Keywords: CAR NK cells; cancer immunotherapy; cell therapy; viral infection; memory NK cells; NK cell targeted therapies; NK-immune cell crosstalk; exosomes
(This special issue belongs to the Section Cellular Immunology)
Glial Cells in Aging Neuroscience
edited by
submission deadline 25 Feb 2025 | Viewed by 297 | Submission Open
Keywords: glial cells; aging; neuroinflammation; neurodegeneration; glial– neuronal interactions; glial– glial crosstalk; astrocytes; oligodendrocytes; microglia; ependymal cells
(This special issue belongs to the Section Cellular Aging)
The Cell Biology of Inositol submission deadline 25 Feb 2025 | Viewed by 207 | Submission Open
Keywords: inositol; organic fluids and tissues; cell membranes and organelles; cell metabolism; nutrition; neurodegenerative diseases; cancer; inositol pyrophosphates; inositol phosphates and phosphoinositides
The Ubiquitin–Proteasome System (UPS): Signaling Processes and Targeted Protein Degradation
edited by
submission deadline 28 Feb 2025 | 6 articles | Viewed by 11474 | Submission Open
Keywords: ubiquitin– proteasome system; ubiquitin ligases; targeted protein degradation; bispecific chimeras; novel chimera approaches
(This special issue belongs to the Section Cell Signaling)
Cellular Regulation of Pathological Proteins in Neurodegenerative Disease
edited by Sonia Sirisi
submission deadline 28 Feb 2025 | 2 articles | Viewed by 6125 | Submission Open
Keywords: protein aggregates; neurodegeneration; neurodegenerative diseases; regulation pathways; misfolded proteins; toxic proteins; homeostasis; autophagy
(This special issue belongs to the Section Cells of the Nervous System)
Platelet Function and Platelet Proteomics in Ageing-Related Diseases
edited by
submission deadline 28 Feb 2025 | 2 articles | Viewed by 6046 | Submission Open
Keywords: thrombosis; platelets; platelet reactivity; platelet function; proteomics; age-related diseases; oxidative stress; mitochondria; microvesicles; thromboinflammation; hemostasis
(This special issue belongs to the Section Cellular Aging)
Research on T Cells in Skin Inflammatory Disorders
edited by and Qing-Sheng Mi
submission deadline 28 Feb 2025 | 1 articles | Viewed by 3338 | Submission Open
Keywords: T cell; vitiligo; atopic dermatitis; T cell lymphoma
(This special issue belongs to the Section Cellular Immunology)
Cellular and Molecular Mechanisms in Bone and Cartilage Damage and Regeneration
edited by
submission deadline 28 Feb 2025 | 3 articles | Viewed by 3221 | Submission Open
Keywords: bone morphogenic proteins (BMPs); bone union with cell therapy; advances in stem cell therapies for fracture non-union and cartilage regeneration; novel cell-based therapies for cartilage repair; functional of collagen/PLA scaffolds in cartilage regeneration; regeneration and revascularization of bone osteonecrosis; evaluation of osteonecrosis regeneration with MRI and histology; and arteriography; identification and validation of new cartilage biomarkers; diaphyseal regeneration with callostasis; union with the membrane technique
(This special issue belongs to the Section Cellular Pathology)
Pulmonary Hypertension: From Molecular and Cellular Mechanisms to Therapeutic Opportunities
edited by
submission deadline 28 Feb 2025 | 2 articles | Viewed by 2980 | Submission Open
Keywords: pulmonary hypertension; molecular mechanism; cellular responses; signaling mechanisms; novel diagnosis and treatments
Harnessing the Tumor Microenvironment and Signaling Pathways for Precision Cancer Therapy
edited by Behzad M. Toosi and
submission deadline 28 Feb 2025 | 2 articles | Viewed by 2784 | Submission Open
Keywords: tumor microenvironment (TME); signaling pathways; precision cancer therapy; immune evasion; metabolic pathways; tumor– stroma interactions; therapeutic targets; personalized medicine; cancer metastasis; molecular oncology
(This special issue belongs to the Section Cell Microenvironment)
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